Results 61 to 70 of about 2,926,291 (344)

Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases. [PDF]

, 2022
Treatment with sotorasib has shown intracranial complete responses and continued intracranial stabilization in KRAS G12C-mutated non-small-cell lung carcinoma (NSCLC) patients with previously treated, stable brain metastases in a post hoc analysis of the
Koster, Kira-Lee, Früh, Martin, Lauber, Arno, Appenzeller, Christina, Schmid, Sabine   +4 more
core   +1 more source

IMpower150 Final Exploratory Analyses for Atezolizumab Plus Bevacizumab and Chemotherapy in Key NSCLC Patient Subgroups With EGFR Mutations or Metastases in the Liver or Brain.

Journal of Thoracic Oncology, 2021
INTRODUCTION Final overall survival (OS) analyses are presented for EGFR mutations and liver or brain metastases subgroups in the phase III IMpower150 study (NCT02366143) evaluating atezolizumab+bevacizumab+carboplatin/paclitaxel (ABCP) or atezolizumab ...
N. Nogami, F. Barlesi, M. Socinski, M. Reck, C. Thomas, F. Cappuzzo, T. Mok, G. Finley, J. Aerts, F. Orlandi, D. Moro-Sibilot, R. Jotte, D. Stroyakovskiy, L. Villaruz, D. Rodríguez-Abreu, D. Lim, D. Merritt, S. Coleman, Anthony Lee, G. Shankar, Wei Yu, I. Bāra, M. Nishio   +22 more
semanticscholar   +1 more source

Identification of CD37, cystatin A, and IL-23A gene expression in association with brain metastasis: analysis of a prospective trial

The International Journal of Biological Markers, 2019
Purpose/Objectives: We aimed to assess the predictive value of a lung cancer gene panel for the development of brain metastases. Materials/Methods: Between 2011 and 2015, 102 patients with lung cancer were prospectively enrolled in a clinical trial in ...
Ammoren Dohm, Jing Su, Emory R. McTyre, James M. Taylor, Lance D. Miller, W. Jeffrey Petty, Fei Xing, Hui-Wen Lo, Linda J. Metheny-Barlow, Stacey O’Neill, Christina Bellinger, Travis Dotson, Boris Pasche, Kounosuke Watabe, Michael D. Chan, Jimmy Ruiz   +15 more
doaj   +1 more source

Serial monitoring of cerebrospinal fluid in patients with leptomeningeal metastases in lung cancer via the Ommaya reservoir as a predictive indicator of therapeutic efficacy and clinical prognosis

npj Precision Oncology
Leptomeningeal metastasis (LM) is a severe neurological complication in patients with lung adenocarcinoma (LUAD), typically indicating terminal stage and poor survival.
Hehui Fang, Haitao Luo, Shujin Li, Naimeng Yan, Shu Xu, Na Liu, Xiaoyue Wang, Ting Xu, Wanwan Cheng, Yong Liu, Chuanyong Yu, Shencun Fang   +11 more
doaj   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

The Incidence of Brain Metastases Among Patients with Metastatic Breast Cancer: A Systematic Review and Meta-Analysis.

Neuro-Oncology, 2020
BACKGROUND Patients with metastatic breast cancer (MBC) are living longer, but development of brain metastases often limits their survival. We conducted a systematic review and meta-analysis to determine the incidence of brain metastases in this patient ...
M. Kuksis, Yizhuo Gao, W. Tran, Christianne Hoey, A. Kiss, A. Komorowski, A. Dhaliwal, A. Sahgal, Sunit Das, Kelvin K. W. Chan, K. Jerzak   +10 more
semanticscholar   +1 more source

Brain Metastasis in Patients with Non-Small Cell Lung Cancer: Immunohistochemical Markers

, 2015
Lung cancer is the leading cause of cancer death in developed countries. Because of the lack of diagnostic tools for early detection and of efficient treatment for advanced disease, the prognosis of lung cancer is still poor, with 5-year survival ...
Saad, Ali G, Ali G. Saad
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The Risk of Hippocampal Metastasis and the Associated High-Risk Factors in 411 Patients With Brain Metastases

Frontiers in Oncology, 2022
Background and AimsTo retrospectively analyze the incidence of hippocampal metastasis and the associated high-risk factors in patients with brain metastases and evaluate the safety of hippocampal avoidance whole-brain radiation therapy (HA-WBRT ...
Peng Xie, Hui Qiao, Huiling Hu, Wenlong Xin, Huanyu Zhang, Ning Lan, Xiaohua Chen, Yan Ma   +7 more
doaj   +1 more source

Treatment strategies for breast cancer brain metastases

British Journal of Cancer, 2020
Brain metastases from breast cancer (BCBM) constitute the second most common cause of brain metastasis (BM), and the incidence of these frequently lethal lesions is currently increasing, following better systemic treatment.
C. Bailleux, Lauriane Eberst, T. Bachelot   +2 more
semanticscholar   +1 more source