Results 71 to 80 of about 2,926,291 (344)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Mutational signatures of synchronous and metachronous brain metastases from lung adenocarcinoma

Experimental Hematology & Oncology, 2023
Brain metastasis (BM) is an important cause of mortality for cancer patients. Many patients were diagnosed with brain metastases at their first visit who have not received any treatment while a subset of patients did not have distant metastases at the ...
Jianing Chen, Hainan Yang, Chao Zhao, Tao Lin, Da Liu, Weiping Hong, Changguo Shan, Cheng Zhou, Ling Bao, Caicun Zhou, Linbo Cai, Chunxia Su, Zhaoming Zhou, Lei Wen   +13 more
doaj   +1 more source

Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma

Nature Genetics, 2020
Brain metastases from lung adenocarcinoma (BM-LUAD) frequently cause patient mortality. To identify genomic alterations that promote brain metastases, we performed whole-exome sequencing of 73 BM-LUAD cases.
D. Shih, D. Shih, Naema Nayyar, Ivanna V. Bihun, Ivanna V. Bihun, I. Dagogo-Jack, C. Gill, C. Gill, Elisa Aquilanti, Elisa Aquilanti, Mia S Bertalan, Alexander Kaplan, M. D’Andrea, U. Chukwueke, F. M. Ippen, Christopher A. Alvarez-Breckenridge, Nicholas D. Camarda, Matthew Lastrapes, D. McCabe, D. McCabe, Benjamin M Kuter, B. Kaufman, B. Kaufman, M. Strickland, J. Martinez-Gutierrez, J. Martinez-Gutierrez, Deepika Nagabhushan, Magali De Sauvage, Michael D. White, Brandyn Castro, Kaitlin Hoang, Andrew Kaneb, Emily Batchelor, S. Paek, S. H. Park, M. Martinez-Lage, A. Berghoff, Parker Merrill, E. Gerstner, T. Batchelor, M. Frosch, Ryan P. Frazier, D. Borger, A. Iafrate, B. Johnson, S. Santagata, S. Santagata, M. Preusser, D. Cahill, S. Carter, P. Brastianos, P. Brastianos   +51 more
semanticscholar   +1 more source

Ex-vivo HRMAS of adult brain tumours: metabolite quantification and assignment of tumour biomarkers [PDF]

, 2010
Background: High-resolution magic angle spinning (HRMAS) NMR spectroscopy allows detailed metabolic analysis of whole biopsy samples for investigating tumour biology and tumour classification.
B Bell, Griffiths, John R, Griffiths John R, Fellows, G.A., Wilson, M, Bell, B Anthony, Wright, Alan J, Wilson M, Fellows, Greg A, Howe, F.A., Bell, B.A., John R Griffiths, Wright, AJ, Wright Alan J, Fellows Greg A, Bell, BA, Bell B, Franklyn A Howe, Alan J Wright, Griffiths, JR, Greg A Fellows, Wright, A.J., Wilson, Martin; id_orcid, Griffiths, J.R., Wilson, M., Fellows, GA, Howe, FA, Howe Franklyn A, Howe, Franklyn A, M Wilson   +29 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Efficacy of Immune Checkpoint Inhibitors in Non-small-cell Lung Cancer Patients With Different Metastatic Sites: A Systematic Review and Meta-Analysis

Frontiers in Oncology, 2020
Background: Organ-specific response patterns reported in previous studies indicate different response toward immune checkpoint inhibitors (ICIs) in non-small-cell lung cancer (NSCLC) patients with different metastatic sites.
Kaili Yang, Jiarui Li, Chunmei Bai, Zhao Sun, Lin Zhao   +4 more
doaj   +1 more source

Methods and results of locoregional treatment of brain metastases in patients with non-small cell lung cancer [PDF]

, 2016
This article presents methods and results of surgery and radiotherapy of brain metastases from non-small cell lung cancer (BMF-NSCLC). Patients with single BMF-NSCLC, with Karnofsky score ≥ 70 and controlled extracranial disease are the best candidates ...
Anna Patla, Walasek, Tomasz, Blecharz, Paweł, Jerzy Jakubowicz, Marian Reinfuss, Patla, Anna, Anna Mucha-Małecka, Jakubowicz, Jerzy, Tomasz Walasek, Mituś, Jerzy, Reinfuss, Marian, Paweł Blecharz, Jerzy Władysław Mituś, Mucha-Małecka, Anna   +13 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Antibody-Drug Conjugates as a Potential a Systemic Treatment Strategy for Brain Metastases in Cases of Solid Tumors

Journal of Oncological Sciences
Large molecular antibody-drug conjugates (ADCs) are able to easily access the site of metastasis in the brain due to the edematous structure of brain metastases, facilitating considerably high concentrations of the cytotoxic component of these ADCs in ...
Didem DİVRİKLİOĞLU, İsmail BAYRAKÇI, Erkan ÖZCAN, İrfan ÇİÇİN   +3 more
doaj   +1 more source

Genomic landscape of the immune microenvironments of brain metastases in breast cancer

Journal of Translational Medicine, 2020
Background This study was intended to investigate the genomic landscape of the immune microenvironments of brain metastases in breast cancer. Methods Three gene expression profile datasets (GSE76714, GSE125989 and GSE43837) of breast cancer with brain ...
Wei-cheng Lu, Hui Xie, Ce Yuan, Jin-jiang Li, Zhao-yang Li, An-hua Wu   +5 more
doaj   +1 more source