Results 71 to 80 of about 1,871,454 (260)
Frontiers in OncologyBackgroundTo investigate the clinical efficacy and potential mechanisms of immune checkpoint inhibitors (PD-1 inhibitors) combined with chemotherapy and targeted therapy in ovarian cancer patients with brain metastases, and to analyze the relationship ...
Yanke Li +4 more
doaj +1 more source
Trials, 2022 Background This study is in regard to the comparison of whole brain radiation therapy for synchronous brain metastases with irradiation protecting the hippocampus versus whole brain radiotherapy for sequential brain metastases to boost irradiation in the
Xiaofang Zhang +6 more
doaj +1 more source
This data package contains the information needed to replicate the research titled - 'Automated segmentation of brain metastases in T1-weighted contrast- enhanced MR images pre and post stereotactic radiosurgery'
Kanakarajan, Hemalatha +3 more
core +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
Journal for ImmunoTherapy of CancerApproximately one-third of patients with metastatic triple-negative breast cancer (TNBC) develop brain metastases during their lifetime. Notably, up to 90% of TNBC brain metastases express B7-H3, a molecule that contributes to an immunosuppressive ...
Jane Bayani +6 more
doaj +1 more source
, 2017 In the past, detection of brain metastases signaled the conclusion of aggressive systemic treatment and shifted the focus of care toward palliation. The median survival for patients with single brain metastasis without brain-directed treatment is about a
David Schiff, Jasmin Jo
core +1 more source
Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang +4 more
wiley +1 more source
PET-CT vs brain MRI for the detection of cerebral metastases of melanoma, a 5-year retrospective study. [PDF]
BACKGROUND Melanoma patients present a high risk of developing extra cutaneous metastases. PET-CT is one of the preferred examinations for the staging of oncological patients.
Benzaquen, Michael Joseph +3 more
core +2 more sources
Advanced Functional Materials, EarlyView.This perspective presents recent advances in electrocatalytic nitrate reduction, focusing on reaction mechanisms, catalyst design, and electrolyzer configurations. Key challenges in selectivity, stability, and practical wastewater treatment are highlighted, while future directions for advancing sustainable ammonia synthesis and nitrate remediation are ...
Xintong Li +9 more
wiley +1 more source