Results 91 to 100 of about 2,926,291 (344)

Cystic brain metastases had slower speed of tumor shrinkage but similar prognosis compared with solid tumors that underwent radiosurgery treatment

Cancer Management and Research, 2019
Hui Wang,* Xiaoye Liu,* Xuechao Jiang, Yongchun Song, Xiaoguang Wang, Jingsheng Wang, Yang Dong, Fengtong Li, Zhiqiang Wu, Yuhan Zhang, Zhiyong Yuan Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National ...
Wang H, Liu X, Jiang X, Song Y, Wang X, Wang J, Dong Y, Li F, Wu Z, Zhang Y, Yuan Z   +10 more
doaj  

Radiosurgery for Five to Fifteen Brain Metastases: A Single Centre Experience and a Review of the Literature

Frontiers in Oncology, 2022
PurposeStereotactic radiosurgery (SRS) is now mainstream for patients with 1-4 brain metastases however the management of patients with 5 or more brain metastases remains controversial.
Susanne J. Rogers, Nicoletta Lomax, Sara Alonso, Tessa Lazeroms, Oliver Riesterer   +4 more
doaj   +1 more source

O-6-Methylguanine-DNA Methyltransferase Expression and Prognostic Value in Brain Metastases of Lung Cancers

, 2011
O(6)-Methylguanine-DNA methyltransferase (MGMT) is critical for repairing pro-mutagenic DNA bases and is correlated with response to alkylating agents in cancers.
吳佩芳;郭冠廷;郭律廷;林怡婷;盧彥伸;楊志新;吳瑞美;杜永光;蔡瑞章;曾漢民;曾勝弘;鄭安理;林璟宏, WU, PEI-FANG;KUO, KUAN-TING;KUO, LU-TING;LIN, YI-TING;LU, YEN-SHEN;YANG, CHIH-HSIN;WU, RUEY-MEEI;TU, YONG-KWANG;TSAI, JUI-CHANG;TSENG, HAN-MIN;TSENG, SHENG-HONG;CHENG, ANN-LII;LIN, CHING-HUNG   +1 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Comparison of whole brain radiation therapy for synchronous brain metastases with irradiation protecting the hippocampus versus whole brain radiotherapy for sequential brain metastases to boost irradiation in the treatment of brain metastases from SCLC: study protocol for a randomized controlled trial

Trials, 2022
Background This study is in regard to the comparison of whole brain radiation therapy for synchronous brain metastases with irradiation protecting the hippocampus versus whole brain radiotherapy for sequential brain metastases to boost irradiation in the
Xiaofang Zhang, Tianlu Wang, Chen Yu Wang, Peng Zhao, Bo Huang, Lei He, Ying Qiu Song   +6 more
doaj   +1 more source

A Phase II Study of Abemaciclib in Patients with Brain Metastases Secondary to Hormone Receptor–Positive Breast Cancer

Clinical Cancer Research, 2020
Purpose: The primary objective was to evaluate intracranial objective response rate (iORR) in patients receiving abemaciclib with brain or leptomeningeal metastases (LM) secondary to hormone receptor–positive (HR+) metastatic breast cancer (MBC ...
S. Tolaney, S. Sahebjam, E. Le Rhun, T. Bachelot, P. Kabos, A. Awada, D. Yardley, A. Chan, P. Conte, V. Diéras, N. Lin, M. Bear, Sonya C. Chapman, Zhengyu Yang, Yanyun Chen, C. Anders   +15 more
semanticscholar   +1 more source

Systemic treatment of non-small cell lung cancer brain metastases

, 2016
In the systemic treatment of brain metastases from non-small cell lung cancer (BMF-NSCLC) chemo- and targeted therapy are used. Response rates after platinum-based chemotherapy, range from 23% to 45%.
Maksymilian A. Kruczała, Tomasz Walasek, Ida Cedrych, Jerzy Jakubowicz, Paweł Blecharz, Marian Reinfuss   +5 more
core   +1 more source

TWIST1 upregulation affects E-cadherin expression in brain metastases

, 2022
Purpose: E-cadherin is a calcium-dependent glycoprotein whose main role is cell-cell adhesion. Its transcriptional repressor TWIST1 is a basic helix-loop-helix (bHLH) protein that participates in gastrulation and formation of mesodermal tissues during ...
Pećina-Šlaus, Nives, Kafka, Anja, Brlek, Petar, Bukovac, Anja   +3 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Evaluation of First-line Radiosurgery vs Whole-Brain Radiotherapy for Small Cell Lung Cancer Brain Metastases: The FIRE-SCLC Cohort Study.

JAMA Oncology, 2020
Importance Although stereotactic radiosurgery (SRS) is preferred for limited brain metastases from most histologies, whole-brain radiotherapy (WBRT) has remained the standard of care for patients with small cell lung cancer.
C. Rusthoven, Masaaki Yamamoto, D. Bernhardt, Derek E. Smith, D. Gao, T. Serizawa, S. Yomo, Hitoshi Aiyama, Y. Higuchi, T. Shuto, A. Akabane, Yasunori Sato, A. Niranjan, A. Faramand, L. Lunsford, J. McInerney, L. Tuanquin, B. Zacharia, V. Chiang, C. Singh, James B. Yu, S. Braunstein, D. Mathieu, C. Touchette, Cheng-chia Lee, Huai-che Yang, A. Aizer, D. Cagney, M. Chan, D. Kondziolka, K. Bernstein, J. Silverman, I. Grills, Zaid A. Siddiqui, Justin C Yuan, J. Sheehan, Diogo Cordeiro, K. Nosaki, T. Seto, C. Deibert, V. Verma, Samuel E. Day, L. Halasz, R. Warnick, D. Trifiletti, J. Palmer, A. Attia, Benjamin Li, Christopher P. Cifarelli, P. Brown, J. Vargo, S. Combs, K. Kessel, S. Rieken, Samir H. Patel, M. Guckenberger, N. Andratschke, B. Kavanagh, T. Robin   +58 more
semanticscholar   +1 more source