Results 11 to 20 of about 2,926,291 (344)

Brain Metastases from Gynecologic Malignancies

Medicina, 2022
Background and Objectives: To present a series of brain metastases from gynecologic primaries and provide a summary of the relevant literature. Materials and Methods: We retrospectively review 18 patients with histologically confirmed brain metastases ...
Georgia Karpathiou, Florian Camy, Céline Chauleur, Maroa Dridi, Pierre Dal Col, Michel Peoc’h   +5 more
doaj   +2 more sources

Prevention of Brain Metastases [PDF]

Frontiers in Neurology, 2018
The incidence of brain metastases is projected to rise because survival rates of lung cancer, breast cancer, and melanoma continue to improve (1). The brain is being identified as a sanctuary site for harboring metastases despite excellent control of extracranial disease.
Joseph A. Bovi
openaire   +4 more sources

New Artificial Intelligence Score and Immune Infiltrates as Prognostic Factors in Colorectal Cancer With Brain Metastases

Frontiers in Immunology, 2021
Incidence of brain metastases has increased in patients with colorectal cancer (CRC) as their survival has improved. CD3 T-cells and, lately, DGMate (DiGital tuMor pArameTErs) score, have been identified as prognostic factors in locally advanced CRC ...
Violaine Randrian, Violaine Randrian, Amandine Desette, Amandine Desette, Sheik Emambux, Sheik Emambux, Valentin Derangere, Pauline Roussille, Eric Frouin, Eric Frouin, Julie Godet, Lucie Karayan-Tapon, Lucie Karayan-Tapon, Lucie Karayan-Tapon, François Ghiringhelli, François Ghiringhelli, David Tougeron, David Tougeron   +17 more
doaj   +1 more source

The Single‐Cell Landscape of Intratumoral Heterogeneity and The Immunosuppressive Microenvironment in Liver and Brain Metastases of Breast Cancer

Advancement of science, 2022
Distant metastasis remains the major cause of morbidity for breast cancer. Individuals with liver or brain metastasis have an extremely poor prognosis and low response rates to anti‐PD‐1/L1 immune checkpoint therapy compared to those with metastasis at ...
Yutian Zou, Feng Ye, Y. Kong, Xiaoqian Hu, X. Deng, Jindong Xie, Cailu Song, Xueqi Ou, Song Wu, Linyu Wu, Yi Xie, Wenwen Tian, Yuhui Tang, Chau-Wei Wong, Zhe‐Sheng Chen, Xinhua Xie, Hailin Tang   +16 more
semanticscholar   +1 more source

Association of Brain Metastases With Immune Checkpoint Inhibitors Efficacy in Advanced Lung Cancer: A Systematic Review and Meta-Analysis

Frontiers in Oncology, 2021
BackgroundIn pivotal immunotherapy trials, the efficacy of immune checkpoint inhibitors as treatments for lung cancer patients with brain metastases remains controversial.
Yanning Wang, Qianning Zhang, Chuansheng Chen, Yuxuan Hu, Liyun Miao, Yujie Zhou   +5 more
doaj   +1 more source

Tucatinib vs Placebo, Both in Combination With Trastuzumab and Capecitabine, for Previously Treated ERBB2 (HER2)-Positive Metastatic Breast Cancer in Patients With Brain Metastases

JAMA Oncology, 2022
Key Points Question Can tucatinib, trastuzumab, and capecitabine provide systemic and intracranial benefit for patients with ERBB2 (HER2)-positive metastatic breast cancer and brain metastases?
N. Lin, R. Murthy, V. Abramson, C. Anders, T. Bachelot, P. Bedard, V. Borges, D. Cameron, L. Carey, A. J. Chien, G. Curigliano, M. DiGiovanna, K. Gelmon, G. Hortobagyi, S. Hurvitz, I. Krop, S. Loi, S. Loibl, V. Mueller, Mafalda Oliveira, E. Paplomata, M. Pegram, D. Slamon, A. Zelnak, J. Ramos, W. Feng, Eric P. Winer   +26 more
semanticscholar   +1 more source

Brain metastases [PDF]

Clinical Medicine, 2014
Brain metastases are the most frequent neurological complication of cancer and the most common brain tumour type. Lung and breast cancers, and melanoma are responsible for up to three-quarters of metastatic brain lesions. Most patients exhibit either headache, seizures, focal deficits, cognitive or gait disorders, which severely impair the quality of ...
Jaime, Gállego Pérez-Larraya, Jerzy, Hildebrand   +1 more
openaire   +4 more sources

The risk and prognostic factors for brain metastases in esophageal cancer patients: an analysis of the SEER database

BMC Cancer, 2021
Background Brain metastases were rare in esophageal cancer patients. Using the Surveillance, Epidemiology, and End Results (SEER) database, the present study investigated the incidence, risk and prognostic factors of brain metastases in esophageal cancer
Shizhao Cheng, Lei Yang, Xin Dai, Jing Wang, Xingpeng Han   +4 more
doaj   +1 more source

Distinct phenotypic states and spatial distribution of CD8+ T cell clonotypes in human brain metastases

Cell Reports Medicine, 2022
Summary Metastatic disease in the brain is difficult to control and predicts poor prognosis. Here, we analyze human brain metastases and demonstrate their robust infiltration by CD8+ T cell subsets with distinct antigen specificities, phenotypic states ...
L. Sudmeier, K. Hoang, E. Nduom, A. Wieland, S. Neill, M. Schniederjan, S. Ramalingam, J. Olson, R. Ahmed, W. Hudson   +9 more
semanticscholar   +1 more source

Immune dysfunction revealed by digital spatial profiling of immuno-oncology markers in progressive stages of renal cell carcinoma and in brain metastases

Journal for ImmunoTherapy of Cancer, 2023
Background The tumor microenvironment (TME) contributes to cancer progression and treatment response to therapy, including in renal cell carcinoma (RCC).
Wei Wei, Michael Hurwitz, Sabina Signoretti, Lucia Jilaveanu, Toni K Choueiri, David L Rimm, Adebowale Adeniran, Sandra Martínez, Harriet M Kluger, David A Schoenfeld, Myrto Moutafi, Dijana Djureinovic, Ross D Merkin, David A Braun, Fabio Parisi   +14 more
doaj   +1 more source