Results 81 to 90 of about 3,661,392 (296)
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi +8 more
wiley +1 more source
Deep brain stimulation for movement disorders
Neurobiology of Disease, 2010 Deep brain stimulation (DBS) is a widely employed therapeutic modality for the treatment of movement disorders. Full FDA approval or humanitarian device exemption has been made for Parkinson's disease, tremor, and dystonia. In this review, we describe the indications and selection criteria, target selection, and outcomes for each of these conditions ...
Kelly L. Collins +2 more
openaire +3 more sources
Pisa Syndrome in Parkinson’s Disease: Electromyographic Aspects and Implications for Rehabilitation
Parkinson's Disease, 2015 Pisa Syndrome (PS) is a real clinical enigma, and its management remains a challenge. In order to improve the knowledge about resting state and during maximal voluntary muscle contraction (MVMC) of the axial muscles, we described the electromyography ...
Giuseppe Frazzitta +10 more
doaj +1 more source
SPG4 and Dementia: Expanding the Clinical Spectrum
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza +19 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon +11 more
wiley +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
New Unity Movement 21st Annual Conference Untitled
, 2006 Agenda of New Unity Movement conference held on the weekend 28 - 30 April 2006.
New Unity Movement
core
Pheochromocytoma with Brain Metastasis: A Extremely Rare Case in Worldwide. [PDF]
, 2018 Pheochromocytoma (PCC) is a neuroendocrine tumor that mainly arises from the medulla of the adrenal gland. Some PCCs become malignant and metastasize to other organs.
조윤성, 김세훈, 강석구
core +1 more source
Early GCase activity is a predictor of long-term cognitive decline in Parkinson’s disease
Translational Neurodegeneration, 2023 Linn Oftedal +7 more
doaj +1 more source