Results 41 to 50 of about 96,104 (260)

Brain Natriuretic Peptide in Hypertension.

Hypertension Research, 1995
Brain natriuretic peptide (BNP) was first identified in the porcine brain and later isolated from porcine, rat, and human hearts. In humans, plasma BNP concentrations are progressively elevated with increasing severity of hypertension, particularly when left ventricular hypertrophy (LVH) is present.
T, Takeda, M, Kohno
openaire   +3 more sources

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Framingham and American College of Cardiology/American Heart Association Pooled Cohort Equations, High‐Sensitivity Troponin T, and N‐Terminal Pro–Brain‐Type Natriuretic Peptide for Predicting Atherosclerotic Cardiovascular Events Across the Spectrum of Kidney Dysfunction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Contemporary guidelines recommend using atherosclerotic cardiovascular disease screening tools to guide primary prevention. The performance of these scores is not well known in patients with moderate to advanced chronic kidney disease ...
Benjamin Lidgard, Leila R. Zelnick, Alan Go, Kevin D. O’Brien, Nisha Bansal   +4 more
doaj   +1 more source

Urinary proteomics for prediction of mortality in patients with type 2 diabetes and microalbuminuria [PDF]

, 2018
Background: The urinary proteomic classifier CKD273 has shown promise for prediction of progressive diabetic nephropathy (DN). Whether it is also a determinant of mortality and cardiovascular disease in patients with microalbuminuria (MA) is unknown.
Currie, Gemma E., Delles, Christian, Flores Guerrero, Jose-Luis, Jacobsen, Peter K., Lindhardt, Morten, Mary, Sheon, Mischak, Harald, Mullen, William, Parving, Hans-Henrik, Reinhard, Henrik, Rossing, Peter, von Scholten, Bernt Johan   +11 more
core   +2 more sources

Resolution of Refractory Multifocal Atrial Tachycardia in Costello Syndrome Using Trametinib: A Case Supporting MEK Inhibitors as Targeted, Specific Antiarrhythmic

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Arrhythmias affect approximately half of patients with Costello syndrome (CS, OMIM # 218040), with non‐reentrant atrial tachycardia being the most common. This case describes an infant with Costello syndrome carrying the pathogenic HRAS c.34G>A (p.G12S) variant who developed early‐onset, drug‐refractory multifocal atrial tachycardia (MAT ...
Vanina Taliercio, Annabelle Wilcox, Stacey Cole, Josue Flores Daboub, José E. Morales Moreno, Kasey G. Andrews, S. Yukiko Asaki, Thomas A. Pilcher, Martin Tristani‐Firouzi, Mary C. Niu, David Viskochil, Benjamin Hammond   +11 more
wiley   +1 more source

Brain Natriuretic Peptide Levels Predict Morbidity and Mortality in Haemodialysis Patients [PDF]

, 2009
Background: Brain natriuretic peptide is a predictor of mortality in multiple cardiovascular diseases but its value in patients with chronic kidney disease is still a matter of debate. Patients and methods: We studied 48 haemodialysis patients with mean
Aires, I, Arranhado, E, Ferreira, A, Gil, C, Gomes, F, Jorge, C, Lage, H, Matias, P   +7 more
core  

Plasma N-Terminal Pro-Brain Natriuretic Peptide as Prognostic Marker in Fatal Cardial Decompensation with Sunitinib Malate Therapy [PDF]

, 2010
A 74-year-old man with metastatic renal cell carcinoma and a history of cardiac failure was treated with sunitinib malate. MUGA echocardiography could not detect a relevant change in the ejection fraction although the clinical situation of the patient ...
Haseke, Nicolas, Stadler, Thomas, Staehler, Michael, Stief, Christian G., Zilinberg, Katja   +4 more
core   +1 more source

Complementary multi‐omics profiling of chronic thromboembolic pulmonary hypertension reveals immune cell alterations, epigenetic changes, and genetically supported candidate genes

Animal Models and Experimental Medicine, EarlyView.
This study presents an integrative multi‐omics framework to uncover the molecular mechanisms and potential biomarkers of chronic thromboembolic pulmonary hypertension (CTEPH). Anthropometric and biochemical data were correlated using canonical correlation analysis, revealing key cardiometabolic associations. Single‐cell RNA sequencing identified immune
Xiaopeng Liu, Xia Zheng, Yajun Zhang, Yinghui Fang, Yanan Zhen   +4 more
wiley   +1 more source

The diagnostic and prognostic role of amino-terminal pro-brain type natriuretic peptides in pediatric cardiac diseases and pulmonary hypertension

Heart Vessels and Transplantation, 2021
Objective: Several studies showed that N-terminal pro-brain type natriuretic peptide (NT-pro-BNP) as the reliable marker both in diagnostic and prognostic workup of pediatric patients with congenital heart disease complicated by pulmonary hypertension ...
Kayirnisa T. Tilemanbetova, Taalaibek Z. Kudaiberdiev, Jalil Sheishenov, Damirbek A. Abibillaev   +3 more
doaj   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source