Results 71 to 80 of about 919,937 (353)

Proton therapy in the treatment of diffuse astrocytoma of the brain stem. Case report

Сибирский онкологический журнал, 2022
Background. Despite the fact that cerebral astrocytoma belongs to low-grade tumors (grade II gliomas), it often leads to disability and death of patients.
T. A. Kireeva, Yu. V. Gumenetskaya, D. V. Gogolin, K. B. Gordon, I. A. Gulidov, O. G. Lepilina   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

H3K9 post-translational modifications regulate epiblast/primitive endoderm specification in rabbit blastocysts

Epigenetics & Chromatin
Post-translational modifications of histone H3 on lysine 9, specifically acetylation (H3K9ac) and tri-methylation (H3K9me3), play a critical role in regulating chromatin accessibility.
Wilhelm Bouchereau, Hong-Thu Pham, Worawalan Samruan, Van-Hong Vu, Thierry Joly, Marielle Afanassieff, Pierre Savatier, Rangsun Parnpai, Nathalie Beaujean   +8 more
doaj   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Limitations of fluorescent timer protein maturation kinetics to isolate transcriptionally synchronized human neural progenitor cells

iScience
Summary: Differentiation of human pluripotent stem cells (hPSCs) into subtype-specific neurons holds substantial potential for disease modeling in vitro.
Manuel Peter, Seth Shipman, Jaewon Heo, Jeffrey D. Macklis   +3 more
doaj   +1 more source

Verification of a Central Pacemaker in Brain Stem by Phase-Coupling Analysis Between HR Interval- and BOLD-Oscillations in the 0.10–0.15 Hz Frequency Band

Frontiers in Neuroscience, 2020
The origin of slow intrinsic oscillations in resting states of functional magnetic resonance imaging (fMRI) signals is still a matter of debate. The present study aims to test the hypothesis that slow blood oxygenation level-dependent (BOLD) oscillations
Gert Pfurtscheller, Gert Pfurtscheller, Andreas R. Schwerdtfeger, Andreas R. Schwerdtfeger, Beate Rassler, Alexandre Andrade, Gerhard Schwarz, Gerhard Schwarz, Wolfgang Klimesch   +8 more
doaj   +1 more source

Endophthalmitis, Cutaneous Nodules, and Brain Lesions in Stem Cell Transplant Recipient [PDF]

, 2023
Dierdre B. Axell‐House, Priyadharsini Nagarajan, Micah M. Bhatti, Rohtesh S. Mehta, Shantanu Roy, Ibne Karim M. Ali, Teny M. John   +6 more
openalex   +1 more source

The systemic environment: at the interface of aging and adult neurogenesis. [PDF]

, 2017
Aging results in impaired neurogenesis in the two neurogenic niches of the adult mammalian brain, the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle.
Smith, Lucas K, Villeda, Saul A, White, Charles W   +2 more
core   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

SP8 Transcriptional Regulation of Cyclin D1 During Mouse Early Corticogenesis

Frontiers in Neuroscience, 2018
Multiple signals control the balance between proliferation and differentiation of neural progenitor cells during corticogenesis. A key point of this regulation is the control of G1 phase length, which is regulated by the Cyclin/Cdks complexes.
Ugo Borello, Ugo Borello, Barbara Berarducci, Edwige Delahaye, David J. Price, Colette Dehay   +5 more
doaj   +1 more source