Results 71 to 80 of about 933,949 (357)

Limitations of fluorescent timer protein maturation kinetics to isolate transcriptionally synchronized human neural progenitor cells

iScience
Summary: Differentiation of human pluripotent stem cells (hPSCs) into subtype-specific neurons holds substantial potential for disease modeling in vitro.
Manuel Peter, Seth Shipman, Jaewon Heo, Jeffrey D. Macklis   +3 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

SP8 Transcriptional Regulation of Cyclin D1 During Mouse Early Corticogenesis

Frontiers in Neuroscience, 2018
Multiple signals control the balance between proliferation and differentiation of neural progenitor cells during corticogenesis. A key point of this regulation is the control of G1 phase length, which is regulated by the Cyclin/Cdks complexes.
Ugo Borello, Ugo Borello, Barbara Berarducci, Edwige Delahaye, David J. Price, Colette Dehay   +5 more
doaj   +1 more source

Nox2 redox signaling maintains essential cell populations in the brain. [PDF]

, 2011
Reactive oxygen species (ROS) are conventionally classified as toxic consequences of aerobic life, and the brain is particularly susceptible to ROS-induced oxidative stress and damage owing to its high energy and oxygen demands.
Chang, Christopher J, Dickinson, Bryan C, Peltier, Joseph, Schaffer, David V, Stone, Daniel   +4 more
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Stem cells and the origin of gliomas: A historical reappraisal with molecular advancements. [PDF]

, 2009
The biology of both normal and tumor development clearly possesses overlapping and parallel features. Oncogenes and tumor suppressors are relevant not only in tumor biology, but also in physiological developmental regulators of growth and differentiation.
Ho, Allen L, Hughes, Samuel, Jandial, Rahul, Levy, Michael L, Menon, Jayant   +4 more
core   +3 more sources

Intrinsic neural stem cell properties define brain hypersensitivity to genotoxic stress [PDF]

, 2022
Argyro Kalogeropoulou, Maria Mougkogianni, Marianna Iliadou, Eleni Nikolopoulou, Stefanos Flordelis, Αλεξάνδρα Κανέλλου, Marina Arbi, Sofia Nikou, Jadwiga Nieminuszczy, Wojciech Niedźwiedź, Dimitrios Kardamakis, Vasiliki Bravou, Zoi Lygerou, Stavros Taraviras   +13 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers

Cell Reports, 2016
The molecular linkage between neocortical projection neuron subtype and area development, which enables the establishment of functional areas by projection neuron populations appropriate for specific sensory and motor functions, is poorly understood ...
Mollie B. Woodworth, Luciano C. Greig, Kevin X. Liu, Gregory C. Ippolito, Haley O. Tucker, Jeffrey D. Macklis   +5 more
doaj   +1 more source

Insights into brain development and disease from neurogenetic analyses in Drosophila melanogaster [PDF]

, 2014
Groundbreaking work by Obaid Siddiqi has contributed to the powerful genetic toolkit that is now available for studying the nervous system of Drosophila.
Reichert, Heinrich
core   +1 more source