Brain organoids and insights on human evolution. [PDF]
, 2019 Human brain organoids, generated from pluripotent stem cells, have emerged as a promising technique for modeling early stages of human neurodevelopment in controlled laboratory conditions.
Muotri, Alysson R
core
A novel and generalizable organotypic slice platform to evaluate stem cell potential for targeting pediatric brain tumors [PDF]
, 2008 Brain tumors are now the leading cause of cancer-related deaths in children under age 15. Malignant gliomas are, for all practical purposes, incurable and new therapeutic approaches are desperately needed.
Li, Shengwen Calvin +1 more
core +4 more sources
Control of cell division in the adult brain by heparan sulfates in fractones and vascular basement membranes [PDF]
, 2010 Regulation of cell division in adult tissues and organs requires the coordination of growth factors at the surface of potentially-dividing cells in specific anatomic loci named germinal niches.
Frederic Mercier, Vanessa Douet
core +1 more source
Quasi-universal scaling in mouse-brain neuronal activity stems from edge-of-instability critical dynamics [PDF]
arXiv, 2021 The brain is in a state of perpetual reverberant neural activity, even in the absence of specific tasks or stimuli. Shedding light on the origin and functional significance of such a dynamical state is essential to understanding how the brain transmits, processes, and stores information. An inspiring, albeit controversial, conjecture proposes that some
arxiv
Persistent Inflammation Alters the Function of the Endogenous Brain Stem Cell Compartment [PDF]
, 2011 Endogenous neural stem/precursor cells (NPCs) are considered a functional reservoir for promoting tissue homeostasis and repair after injury, therefore regenerative strategies that mobilize these cells have recently been proposed.
Alfaro-Cervello, Clara +13 more
core +1 more source
Comparative approaches to understanding thyroid hormone regulation of neurogenesis [PDF]
, 2019 Thyroid hormone (TH) signalling, an evolutionary conserved pathway, is crucial for brain function and cognition throughout life, from early development to ageing. In humans, TH deficiency during pregnancy alters offspring brain development, increasing the risk of cognitive disorders.
arxiv +1 more source
The taxonomy of brain cancer stem cells: What\u27s in a name? [PDF]
, 2014 With the increasing recognition that stem cells play vital roles in the formation, maintenance, and potential targeted treatment of brain tumors, there has been an exponential increase in basic laboratory and translational research on these cell types ...
Gutmann, David H
core +2 more sources
NANOG Is Required for the Long-Term Establishment of Avian Somatic Reprogrammed Cells
Stem Cell Reports, 2018 Summary: Somatic reprogramming, which was first identified in rodents, remains poorly described in non-mammalian species. Here, we generated avian reprogrammed cells by reprogramming of chicken and duck primary embryonic fibroblasts.
Aurélie Fuet +6 more
doaj
Revista da Sociedade Brasileira de Fonoaudiologia, 2009 Preconiza-se o diagnóstico até os três meses de idade em crianças com deficiência auditiva congênita. Após a etapa inicial de confirmação do diagnóstico, é necessário que se obtenha limiares precisos nas diferentes frequências, para que seja possível uma
Gabriela Ribeiro Ivo Rodrigues +2 more
doaj +1 more source
Review of Clinical Trials Using Neural Stem Cells [PDF]
, 2016 The use of stem cells in clinical trials started several years ago for regenerativebased therapies or for the treatment of tumours. After brain injuries or neurodegenerative diseases, neural stem cells represent a promising strategy to repair the ...
C. Lépinoux-Chambaud +2 more
core +1 more source