Results 61 to 70 of about 5,354,766 (334)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Inhibit My Disinhibition: The Role of the Inferior Frontal Cortex in Sexual Inhibition and the Modulatory Influence of Sexual Excitation Proneness

Frontiers in Human Neuroscience, 2018
Sexual behaviour is the result of an interplay between distinct neural inhibitory and excitatory mechanisms. Individual differences in sexual excitation and sexual inhibition are proposed to play an important role in the processes sustaining the ...
Geraldine Rodriguez, Alexander T. Sack, Marieke Dewitte, Teresa Schuhmann   +3 more
doaj   +1 more source

A computational model for real-time calculation of electric field due to transcranial magnetic stimulation in clinics [PDF]

, 2015
The aim of this paper is to propose an approach for an accurate and fast (real-time) computation of the electric field induced inside the whole brain volume during a transcranial magnetic stimulation (TMS) procedure. The numerical solution implements the
Apollonio, Francesca, Camera, Francesca, Carducci, Filippo, Liberti, Micaela, Paffi, Alessandra, Rubino, Gianluigi, Tampieri, Paolo   +6 more
core   +3 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Early differences in lassitude predicts outcomes in Stanford Neuromodulation Therapy for difficult to treat depression

npj Mental Health Research
Stanford Neuromodulation Therapy (SNT), has recently shown rapid efficacy in difficult to treat (DTT) depression. We conducted an exploratory analysis of individual symptom improvements during treatment, correlated with fMRI, to investigate this rapid ...
David Benrimoh, Azeezat Azeez, Jean-Marie Batail, Xiaoqian Xiao, Derrick Buchanan, Igor D. Bandeira, Andrew Geoly, Yaakov Keynan, Ian H. Kratter, Nolan R. Williams   +9 more
doaj   +1 more source

Noninvasive Brain Stimulation and Personal Identity: Ethical Considerations. [PDF]

, 2017
As noninvasive brain stimulation (NIBS) technology advances, these methods may become increasingly capable of influencing complex networks of mental functioning. We suggest that these might include cognitive and affective processes underlying personality
Iwry, Jonathan, Newberg, Andrew B., Yaden, David B.   +2 more
core   +3 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Using Remotely Supervised At-Home TES for Enhancing Mental Resilience

Frontiers in Human Neuroscience, 2022
We are in the midst of a mental health crisis with major depressive disorder being the most prevalent among mental health disorders and up to 30% of patients not responding to first-line treatments.
Jasmina Paneva, Jasmina Paneva, Inge Leunissen, Inge Leunissen, Teresa Schuhmann, Teresa Schuhmann, Teresa Schuhmann, Tom A. de Graaf, Tom A. de Graaf, Tom A. de Graaf, Morten Gørtz Jønsson, Morten Gørtz Jønsson, Balder Onarheim, Alexander T. Sack, Alexander T. Sack, Alexander T. Sack, Alexander T. Sack   +16 more
doaj   +1 more source

Deep brain stimulation of the brainstem.

Brain : a journal of neurology, 2020
Deep brain stimulation (DBS) of the subthalamic nucleus, pallidum, and thalamus is an established therapy for various movement disorders. Limbic targets have also been increasingly explored for their application to neuropsychiatric and cognitive ...
G. Elias, A. Loh, Dave Gwun, Aditya Pancholi, A. Boutet, C. Neudorfer, Jurgen Germann, Andrew A. Namasivayam, R. Gramer, Michelle Paff, A. Lozano   +10 more
semanticscholar   +1 more source