Results 71 to 80 of about 1,099,665 (274)

About deep brain stimulation [PDF]

Neurology, 2015
Deep brain stimulation (DBS) is a surgery that is used to treat a number of disabling symptoms of neurologic diseases. These include symptoms of Parkinson disease (PD), essential tremor, dystonia, or obsessive-compulsive disorder. It has also been used in Tourette syndrome, neuropathic pain, and depression. A report of the first successful clinical use
João, Massano, Alexander I, Tröster
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Investigating the electrical response of the brain of the domestic chicken (Gallus gallus domesticus) to nociception through the use of depth electroencephalography (dEEG) : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Physiology at Massey University, Manawatū, New Zealand [PDF]

, 2015
Nociception is an unavoidable side effect of many routine management and clinical procedures in animals. Electroencephalography (EEG) has previously been used to investigate the effect of nociception on mammalian brain activity.
Trebilcock, Peter Dennis
core  

Informed consent decision-making in deep brain stimulation [PDF]

, 2018
Deep brain stimulation (DBS) has proved useful for several movement disorders (Parkinson’s disease, essential tremor, dystonia), in which first and/or second line pharmacological treatments were inefficacious.
Appelbaum, Bell, Berg, Gilbert, Grisso, Jahanshahi, Mehdorn   +6 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain [PDF]

, 2016
Background: The relationship between the brain and the immune system has become increasingly topical as, although it is immune-specialised, the CNS is not free from the influences of the immune system.
A Boivin, A Constant, A Walter, AD Bachstetter, Alison McColl, B Winner, BT Fife, C Callewaere, C D'Mello, C Gemma, CA Thomson, Carolyn A. Thomson, CP Marques, CS McKimmie, CT Ekdahl, D Michlmayr, D Michlmayr, EE Ubogu, G Banisadr, G Banisadr, Gerard J. Graham, JH Dufour, JL Teeling, Jonathan Cavanagh, JS Cameron, JS Snyder, JT Rogers, L Azzi, L Cartier, L Fits van der, Louis Nerurkar, M Baggiolini, M Udina, ML Monje, MM Lee, N Andrews, Q Liu, R Dantzer, R Deacon, R Krishnan, R Rola, RM Deacon, RM Ransohoff, S Baraldi, S Goethals, S Potvin, S Tyring, SM O'Brien, U Patel, U Puntener, W Huang da, W Huang da, W Rostene, WJ Karpus   +53 more
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Causal connectivity maps derived from single-pulse interleaved TMS/fMRI

Scientific Reports
Understanding causal interactions between cortical and subcortical brain regions is critical for mapping human functional connectivity. While non-invasive methods such as fMRI and diffusion imaging have provided valuable insights into brain connectivity,
Lison Bossus, Jess Dickson, Camille Blaine, Hasti Khalilkhani, Ahsan Khan, Desmond J. Oathes   +5 more
doaj   +1 more source

Distinct patterns of temporal and directional connectivity among intrinsic networks in the human brain [PDF]

, 2017
To determine the spatiotemporal relationships among intrinsic networks of the human brain, we recruited seven neurosurgical patients (four males and three females) who were implanted with intracranial depth electrodes.
Bickel, Stephan, Foster, Brett L, Hsiang, Jen Chun, Hsieh, Liang-Tien, Kucyi, Aaron, Liu, Hesheng, Parvizi, Josef, Poldrack, Russell A, Shine, James M, Wang, Danhong   +9 more
core   +2 more sources

Directional Deep Brain Stimulation [PDF]

Neurotherapeutics, 2019
Over the last years, deep brain stimulation has seen many technological innovations. New electrode designs allowing to direct the current flow not only in the vertical but also in the horizontal plane are the most recent. We summarize the concept of "directional deep brain stimulation" with its opportunities and challenges and the available study data ...
Frank Steigerwald, Cordula Matthies, Jens Volkmann   +2 more
openaire   +2 more sources