Results 41 to 50 of about 831,573 (301)

Upfront Brain Treatments Followed by Lung Surgery Improves Survival for Stage IV Non-small Cell Lung Cancer Patients With Brain Metastases: A Large Cohort Analysis

Frontiers in Surgery, 2021
Background: Current treatment guidelines for stage IV non-small cell lung cancer (NSCLC) with brain metastases recommend brain treatments, including surgical resection and radiotherapy (RT), in addition to resection of the primary lung tumor.
Xiaopeng He, Xiaopeng He, Shen Yin, Shen Yin, Hongyu Liu, Rong Lu, Kemp Kernstine, David E. Gerber, David E. Gerber, David E. Gerber, Yang Xie, Yang Xie, Yang Xie, Donghan M. Yang   +13 more
doaj   +1 more source

Myeloid Cell Classification and Therapeutic Opportunities Within the Glioblastoma Tumor Microenvironment in the Single Cell-Omics Era

Frontiers in Immunology, 2022
The glioma tumor microenvironment (TME) is complex and heterogeneous, and multiple emerging and current technologies are being utilized for an improved comprehension and understanding of these tumors.
Collin J. Larkin, Víctor A. Arrieta, Víctor A. Arrieta, Víctor A. Arrieta, Hinda Najem, Hinda Najem, Gongbo Li, Gongbo Li, Peng Zhang, Peng Zhang, Jason Miska, Jason Miska, Peiwen Chen, Peiwen Chen, Charles David James, Charles David James, Adam M. Sonabend, Adam M. Sonabend, Amy B. Heimberger, Amy B. Heimberger   +19 more
doaj   +1 more source

Fluorescence-guided surgery for brain tumors [PDF]

CNS Oncology, 2012
5-aminolevulinic acid-induced protoporphyrin IX fluorescence was authorized in the EU for visualization of tumor tissue during surgery for WHO grade III and IV gliomas in 2007. It facilitates tumor identification and doubles the number of gross total resections that can be achieved in these tumors.
openaire   +2 more sources

Evaluating the significance of HIV status in patients with neoplastic brain tumors admitted to a single neurosurgical center in South Africa – A prospective cohort study

Interdisciplinary Neurosurgery, 2020
Introduction: While global awareness of HIV disease has grown exponentially due to public awareness initiatives, the specifics of the impact of being HIV positive in patients presenting with brain tumours is lacking. Materials and methods: We conducted a
Adrian Kelly, Patrick Lekgwara
doaj   +1 more source

Microsurgery vs. radiosurgery for the treatment of multiple metastases in the brain: a retrospective cohort study

Cancer Biology & Medicine, 2022
Objective: Multiple brain metastases are a severe condition for cancer patients. To date, no general consensus exists regarding the optimal treatment procedure for multiple brain metastases. Radiotherapy is the most commonly used treatment option.
Qun Liu, Qiang Yin, Yang Dong, Fengtong Li, Wenliang Li, Xiaoguang Wang   +5 more
doaj   +1 more source

Anti-VEGF Antibody Treatment of Glioblastoma Prolongs Survival But Results in Increased Vascular Cooption

Neoplasia: An International Journal for Oncology Research, 2000
Vascular endothelial growth factor (VEGF) is an important mediator of the intense angiogenesis which is characteristic of glioblastoma. While genetic manipulation of VEGF/VEGF receptor expression has previously been shown to inhibit glioblastoma growth ...
James L. Rubenstein, Jin Kim, Tomoko Ozawa, Michael Zhang, Manfred Westphal, Dennis F. Deen, Marc A. Shuman   +6 more
doaj   +1 more source

Using preoperative FLAIR signal abnormality to guide extent of resection for management of brain tumor-related epilepsy: 2 Case reports of malignant tumors

Interdisciplinary Neurosurgery, 2023
Background: Brain tumor-related epilepsy is characterized by at least one unprovoked seizure in a patient with a brain tumor confirmed by magnetic resonance imaging (MRI). Seizure outcomes correlate with extent of tumor resection.
Xavier T.J. Hsu, Shu-Fen Feng, Shing-Su Chen, Yi-Hsin Liu, Andrew T. Huang   +4 more
doaj   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Phase II trial of upfront bevacizumab and temozolomide for unresectable or multifocal glioblastoma

Cancer Medicine, 2013
Patients with unresectable glioblastomas have a poor prognosis, with median survival of 6–10 months. We conducted a phase II trial of upfront 5‐day temozolomide (TMZ) and bevacizumab (BV) in patients with newly diagnosed unresectable or multifocal ...
Emil Lou, Katherine B. Peters, Ashley L. Sumrall, Annick Desjardins, David A. Reardon, Eric S. Lipp, James E. Herndon II, April Coan, Leighann Bailey, Scott Turner, Henry S. Friedman, James J. Vredenburgh   +11 more
doaj   +1 more source

Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations

Journal for ImmunoTherapy of Cancer, 2019
Background D2C7-IT is a novel immunotoxin (IT) targeting wild-type epidermal growth factor receptor (EGFRwt) and mutant EGFR variant III (EGFRvIII) proteins in glioblastoma.
Vidyalakshmi Chandramohan, Xuhui Bao, Xin Yu, Scott Parker, Charlotte McDowall, Yen-Rei Yu, Patrick Healy, Annick Desjardins, Michael D. Gunn, Matthias Gromeier, Smita K. Nair, Ira H. Pastan, Darell D. Bigner   +12 more
doaj   +1 more source