Results 81 to 90 of about 6,149,012 (253)

Epigenomics and immunotherapeutic advances in pediatric brain tumors

npj Precision Oncology, 2021
Brain tumors are the leading cause of childhood cancer-related deaths. Similar to adult brain tumors, pediatric brain tumors are classified based on histopathological evaluations. However, pediatric brain tumors are often histologically inconsistent with
Malak Abedalthagafi, Nahla Mobark, May Al-Rashed, Musa AlHarbi   +3 more
doaj   +1 more source

Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma. [PDF]

, 2015
Medulloblastoma (MB) is a highly malignant brain tumor that occurs primarily in children. Although surgery, radiation and high-dose chemotherapy have led to increased survival, many MB patients still die from their disease, and patients who survive ...
Berezov, A, Brun, SN, Conway, EM, Crawford, JR, Esparza, LA, Garcia, G, Grant, GA, Greene, MI, Huang, J-M, Levy, ML, Li, X-N, Markant, SL, Nakano, I, Pavlyukov, MS, Smith, LH, Terry, D, Wang, Q, Wechsler-Reya, RJ   +17 more
core   +2 more sources

Artificial neural network identified a 20‐gene panel in predicting immunotherapy response and survival benefits after anti‐PD1/PD‐L1 treatment in glioblastoma patients

Cancer Medicine
Background Immune checkpoint inhibitors (ICIs) are a promising immunotherapy approach, but glioblastoma clinical trials have not yielded satisfactory results. Objective To screen glioblastoma patients who may benefit from immunotherapy.
Yaning Wang, Zihao Wang, Xiaopeng Guo, Yaning Cao, Hao Xing, Yuekun Wang, Bing Xing, Yu Wang, Yong Yao, Wenbin Ma   +9 more
doaj   +1 more source

Visual hallucinations in neurosurgery: A systematic review and two case insights into Charles Bonnet Syndrome

Brain and Spine
Introduction: Visual disturbances in brain tumor patients occur as a direct consequence of tumor location or as a complication after surgery. These can range from minor vision changes to severe impairments, including visual hallucinations.
Erica Grasso, Giulio Bonomo, Francesco Certo, Giacomo Cammarata, Giuseppe M.V. Barbagallo   +4 more
doaj   +1 more source

Classification using deep learning neural networks for brain tumors

Future Computing and Informatics Journal, 2017
Deep Learning is a new machine learning field that gained a lot of interest over the past few years. It was widely applied to several applications and proven to be a powerful machine learning tool for many of the complex problems.
Heba M. Mohsen, E. El-Dahshan, El-Sayed M. El-Horbaty, A. M. Salem   +3 more
semanticscholar   +1 more source

Pan-cancer analysis reveals SMARCAL1 expression is associated with immune cell infiltration and poor prognosis in various cancers

Scientific Reports
Although immune checkpoint inhibition in particular has shown promise in cancer immunotherapy, it is not always efficient. Recent studies suggest that SMARCAL1 may play a role in tumor immune evasion, yet its pan-cancer role is unclear.
Wu-jie Zhao, Meng-lei Wang, Yun-fang Zhao, Wen-peng Zhao, Qiong-hui Huang, Zhen-wei Lu, Fang Jia, Jin-jin Shi, Bo-sen Liu, Wan-hong Han, Han-wen Lu, Bing-chang Zhang, Zhan-xiang Wang   +12 more
doaj   +1 more source

In vivo investigation of hyperpolarized [1,3-13C2]acetoacetate as a metabolic probe in normal brain and in glioma. [PDF]

, 2019
Dysregulation in NAD+/NADH levels is associated with increased cell division and elevated levels of reactive oxygen species in rapidly proliferating cancer cells.
Batsios, Georgios, Gillespie, Anne Marie, Le Page, Lydia M, Najac, Chloé, Radoul, Marina, Ronen, Sabrina M, Subramani, Elavarasan, Viswanath, Pavithra   +7 more
core   +3 more sources

3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors

Nature Communications, 2019
Dynamic alterations in the unique brain extracellular matrix (ECM) are involved in malignant brain tumors. Yet studies of brain ECM roles in tumor cell behavior have been difficult due to lack of access to the human brain.
Disha Sood, M. Tang-Schomer, Dimitra Pouli, C. Mizzoni, Nicole Raia, A. Tai, K. Arkun, Julian K. Wu, Lauren D. Black, B. Scheffler, I. Georgakoudi, D. Steindler, D. Kaplan   +12 more
semanticscholar   +1 more source

Effectiveness and safety of stellate ganglion block with trioxygen autologous blood retransfusion therapy for facial postherpetic neuralgia in elderly patients

Scientific Reports
This study evaluated the efficacy and safety of stellate ganglion block (SGB) combined with trioxygen autologous blood retransfusion therapy (TABRT) in treating postherpetic neuralgia (PHN) of the head and face in elderly patients.
Chan Zheng, Yuanyuan Xie, Huijuan Li, Bingchang Zhang, Sifang Chen, Wanhong Han, Jiacheng Liu, Yanyan Geng, Yaya Zhang, Zhanxiang Wang   +9 more
doaj   +1 more source

Specific Preferences in Lineage Choice and Phenotypic Plasticity of Glioma Stem Cells Under BMP4 and Noggin Influence [PDF]

, 2015
Although BMP4-induced differentiation of glioma stem cells (GSCs) is well recognized, details of the cellular responses triggered by this morphogen are still poorly defined.
Arakaki, Naomi, Fernandez Espinosa, Damian Dario, Garcia, Carolina Paola, Martinetto, Horacio Enrique, Miriuka, Santiago Gabriel, Roisman, Alejandro, Romorini, Leonardo, Scassa, Maria Elida, Sevlever, Gustavo Emilio, Slavutsky, Irma Rosa, Videla Richardson, Guillermo Agustín   +10 more
core   +1 more source