Results 51 to 60 of about 80,558 (315)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Strengthening elements of steel structures for controlling fatigue fracture

Metalurgija, 2021
The article deals with the issues of reliable operation of steel structures of mine hoisting machines. It is proposed to strengthen the “weak points” of the braking device beam structure, which will further prevent the formation and growth of cracks in ...
P. A. Kropachev, A. D. Mekhtiyev, Y. Zh. Sarsikeyev   +2 more
doaj  

Analysis Method to Study the Potentials in Recovering the Brake Energy in Articulated Haulers [PDF]

, 2014
An analysis method to study the potentials of recovering the brake energy from Volvo articulated haulers has been developed. The study has been carried out with purpose to find out how and where possible hybrid solutions can be used.
Mandeep Singh Walia, Håkansson, Lars,, Gaurav Chopra, Walia, Mandeep,, Magnus Karlsson, Lars Hakansson, Karlsson, Magnus,, Chopra, Gaurav,   +7 more
core   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Influence of Surface Finish on the Tribological Performance of AlTiBN Coatings Deposited on Forming Tools

Advanced Engineering Materials, EarlyView.
Aluminum and nitride coatings are used in industry because they are hard, resist wear, and protect against oxidation. Adding boron can improve friction behavior and other properties. This study tests coatings on surfaces with different finishes. Results show smoother surfaces perform better, while rough ones wear faster, although coatings can reduce ...
Adrián Claver, Iker Alfonso, Eneko Barba, Javier León, José Antonio García, Iñaki Zalakain, Iván Fernández Martínez, Arley García‐Carrero, Christian Almeyda, Daniel Salcedo   +9 more
wiley   +1 more source

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells

Advanced Healthcare Materials, EarlyView.
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin   +7 more
wiley   +1 more source

Strong‐Magnetic Flexible Composites for Magnetically Responsive Soft Robots

Advanced Robotics Research, EarlyView.
This perspective provides an overview of the performance mechanisms, preparation methods, and applications of strong magnetic flexible composite materials in soft actuators (such as gripping, movement, and sensing), and further explores current opportunities and challenges.
Wenwen Li, Shuai Liu, Xinyi Wang, Xinglong Gong, Shouhu Xuan   +4 more
wiley   +1 more source

Nonlocomotory Robotic Strategies for Dynamic Rotation Control in Terrestrial Robots: A Review

Advanced Robotics Research, EarlyView.
Terrestrial robots increasingly require rapid body rotation to maintain stability and agility in complex environments. This review shows nonlocomotory rotational control strategies that operate without ground contact, including reaction wheels, tails, bars, limbs, and thrusters.
Y. Liang, J. An, X. Zheng, D. Wang, S. Wang, X. Wang, P. Zhu, J. Pei, S. Li, J. Paripurana, Y. Han, Z. Tang, X. Gan, Q. He, X. Ma   +14 more
wiley   +1 more source

Multimodal Locomotion in Insect‐Inspired Microrobots: A Review of Strategies for Aerial, Surface, Aquatic, and Interfacial Motion

Advanced Robotics Research, EarlyView.
This review identifies key design considerations for insect‐inspired microrobots capable of multimodal locomotion. To draw inspiration, biological and robotic strategies for moving in air, on water surfaces, and underwater are examined, along with approaches for crossing the air–water interface.
Mija Jovchevska, Kaushik Jayaram, Nicole Xu   +2 more
wiley   +1 more source

THE EXPERIMENTAL DIDACTIC STAND FOR DETERMINING THE PARAMETERS OF THE GEAR WITH MAGNETORHEOLOGICAL CLUTCH AND BRAKE [PDF]

Scientific Journal of Silesian University of Technology. Series Transport, 2014
In this paper the laboratory stand, designed to be used as a part of the Laboratory of Machine Design and Research which is part of the subject Fundamentals of Machine Design, is presented.
Jerzy BAJKOWSKI
doaj