Results 121 to 130 of about 4,018 (263)

Comprehensive transduceromic profiling of NOP receptor ligands at different Gα subunits

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) is an opioid receptor family member with distinct pharmacology and broad therapeutic potential. NOP receptors regulate functions such as nociception, stress reactivity, reward, mood, autonomic tone, immunity and sleep/wake cycle.
Davide Malfacini   +9 more
wiley   +1 more source

Alternative Polyadenylation Drives Runaway Pro‐Inflammatory Macrophages in Periodontitis by Enabling Escape From miRNA Repression

open access: yesCell Proliferation, EarlyView.
APA‐Guided Therapeutic miRNA Selection for Periodontitis. ABSTRACT Periodontitis is a chronic inflammatory disease driven by a dysregulated host immune response, in which macrophage‐mediated inflammation shifts from protective to pathological. While monocyte‐derived macrophages (MDMs) are known to adopt a destructive, M1‐like pro‐inflammatory phenotype,
Jing Zhang   +6 more
wiley   +1 more source

Cross‐border reciprocal bartering in public–private tetradic networks

open access: yesDecision Sciences, EarlyView.
Abstract Under the background of semiconductor and vaccine shortages during COVID‐19‐driven supply chain disruptions, this article adopts a multimethodological approach to investigate strategic solutions for cross‐border scarce goods bartering in a public–private (P–P) tetradic reciprocal network, which involves two pairs of P–P collaborative dyads ...
Jiuh‐Biing Sheu   +2 more
wiley   +1 more source

The commercialization of labour markets: Evidence from wage inequality in the Middle Ages

open access: yesThe Economic History Review, EarlyView.
Abstract This paper moves beyond the focus on ‘average’ wage trends in pre‐industrial economies by examining the broad diversity of pay rates and forms of remuneration across occupations and regions in medieval England. We find that whilst some workers enjoyed substantial growth in wage rates after the Black Death, there was a large group who ...
Jordan Claridge   +2 more
wiley   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

open access: yesThe FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto   +9 more
wiley   +1 more source

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