Results 161 to 170 of about 4,631 (294)

Dental Pulp Stem Cell‐Derived Intracellular Vesicles Inhibit OSCC by Delivering PTEN to Suppress PI3K/AKT/mTOR Signalling Pathway

Cell Proliferation, EarlyView.
DPSC‐IVs suppressed PI3K/AKT/mTOR signalling pathway by delivering PTEN to tumour cells, which reduced the expression of Bcl‐2 and elevated that of Bax. Meanwhile, DPSC‐IVs activated PINK1/Parkin mediated mitophagy, which further raised ROS levels.
Yu Luo, Qiang Qin, Wenting She, Xiangying Wang, Xiqin Li, Chenxuan Shu, Ruohan Li, Ziwei Li, Dongjie Fu, Yan He, Qingsong Ye   +10 more
wiley   +1 more source

Tribological characteristics of composite brake pads under variable load and speed. [PDF]

Sci Rep
Essam MA, Faragallah MM, Abdeltawab NM, Ali M.   +3 more
europepmc   +1 more source

The commercialization of labour markets: Evidence from wage inequality in the Middle Ages

The Economic History Review, EarlyView.
Abstract This paper moves beyond the focus on ‘average’ wage trends in pre‐industrial economies by examining the broad diversity of pay rates and forms of remuneration across occupations and regions in medieval England. We find that whilst some workers enjoyed substantial growth in wage rates after the Black Death, there was a large group who ...
Jordan Claridge, Vincent Delabastita, Spike Gibbs   +2 more
wiley   +1 more source

Simulation and optimization of train brake disc based on coupling characteristics of FEM and thermal flow density method. [PDF]

Sci Rep
Qi G, Jiao P, Du W, Zhang Y, Chen B.
europepmc   +1 more source

Extreme weather and economic crisis in the 1430s in England, and the implications for tenurial change

The Economic History Review, EarlyView.
Abstract The 1430s were characterized by extreme weather conditions, food and fodder shortages, and high mortalities among animals and humans, although the severity of events and their consequences in England have received limited attention. The economic downturn and the depressed customary land market in this decade marked the beginning of the Great ...
Mark Bailey
wiley   +1 more source

The Cutting Edge Geometric Optimization of the PCBN Tool for the Machining of Cast Iron. [PDF]

Micromachines (Basel)
Wu X, Su Z, Zhang C, Zhao X, Yao H, Jiang F.   +5 more
europepmc   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Real-Time Defect Identification in Automotive Brake Calipers Using PCA-Optimized Feature Extraction and Machine Learning. [PDF]

Sensors (Basel)
Lee J, Woo U, Lee MH, Kim JY, Choi H, Oh T.   +5 more
europepmc   +1 more source

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, EarlyView.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source

Comparative Validation of the fBrake Method with the Conventional Brake Efficiency Test Under UNE 26110 Using Roller Brake Tester Data. [PDF]

Sensors (Basel)
Romero-Gómez V, San Román JL.
europepmc   +1 more source