Results 71 to 80 of about 4,631 (294)

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Torque Coordination Control of an Electro-Hydraulic Composite Brake System During Mode Switching Based on Braking Intention

Energies, 2020
The electro-hydraulic composite braking system of a pure electric vehicle can select different braking modes according to braking conditions. However, the differences in dynamic response characteristics between the motor braking system (MBS) and ...
Yang Yang, Yundong He, Zhong Yang, Chunyun Fu, Zhipeng Cong   +4 more
doaj   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

A study on the asynchronous brake lock-up of a statically indeterminate tractor with an air suspension

, 2011
The paper aims to resolve the practical problems of asynchronous brake lock-up which acts on the wheels of statically indeterminate tractors with an air suspension.
Liang Yingchun, Shi Guang, Wang Xuanfeng, Huang Chaosheng, Ying Guozeng   +4 more
core   +1 more source

Control Strategy and Simulation of the Regenerative Braking of an Electric Vehicle Based on an Electromechanical Brake

, 2022
The electromechanical brake (EMB) has very broad prospects for application in the automotive industry, especially in small- and medium-sized vehicles.
Zhou, Shuwen, Liu, Jinshuang, Wang, Qingyun   +2 more
core   +1 more source

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

Design Explorations on the Brake Force Distributions of a Motorbike

Journal of Applied Engineering Design and Simulation
The braking system is crucial for motorbike safety, as effective braking ensures both deceleration and stability. This study investigates the influence of the deceleration rate and the combined biker and pillion load on the optimal distribution of the braking force of a motorbike.
Mahamad Hisyam Mahamad Basri, Noor Iswadi Ismail, Muhammad Arif AB Hamid Pahmi, Rosniza Rabilah, Hazim Sharudin   +4 more
openaire   +1 more source

Automation of Surgical Workflow Recognition: Unveiling the Surgical Instrument Kinematics that Underly Robot‐Assisted Prostatectomy Procedures

Advanced Intelligent Discovery, EarlyView.
Automated procedural analysis is recognized as one of the major game changers for robotic surgery. Meaning digital analysis needs to replace the manual assessments that set todays standard. Mechanical robotic‐instrument tracking enables the derivation of quantitative kinematic metrics that support behavior‐based workflow segmentation into distinct ...
Kateryna Pirkovets, Matthias N. van Oosterom, Vera A. Ottens, Henk G. van der Poel, Fijs W. B. van Leeuwen   +4 more
wiley   +1 more source

Autonomous X‐Ray Fluorescence Mapping for Nanoscale Chemical Speciation of Fine Particulate Matter

Advanced Intelligent Discovery, EarlyView.
We present X‐AutoMap, an autonomous X‐ray fluorescence mapping framework that integrates real‐time analysis with rule‐based computer vision to selectively target chemically relevant regions. By avoiding background‐dominated areas, the method reduces acquisition time by fourfold while enabling accurate particle‐level speciation.
Carlos Deleon, Dmitri Gavrilov, Peggy O’Day, Ajith Pattammattel   +3 more
wiley   +1 more source