Results 61 to 70 of about 93,942 (223)

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

The Measurement and Analysis of the Disc/Pad Interface Dynamic Centre of Pressure and its Influence on Brake Noise. [PDF]

, 2008
This paper discusses the measurement of the dynamic centre of pressure (CoP) of a brake pad during a normal braking event using a modified 12-piston opposed calliper. The modifications allow the centre of pressure to be controlled both radially and along
John D. Fieldhouse, Talbot, Chris J., Fieldhouse, John D., Chris Talbot, Ashraf, Naveed, Naveed Ashraf   +5 more
core   +1 more source

Effects of Titanate on Brake Wear Particle Emission Using a Brake Material Friction Test Dynamometer

Lubricants
We investigated the effect of lepidocrocite-type layered titanate, which is compounded in brake pads, to reduce brake particle emissions. The dust reduction effect of titanate was evaluated using a small-scale inertial brake material friction test ...
Emiko Daimon, Yasuhito Ito
doaj   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

The Study Of Friction Coefficient, Brake Pads Temperature And Addhesive Resistance On Brake Pads Using Fly Ash Coal [PDF]

, 2014
Brake pads are one component of a motor vehicle which is used to slowor stop the vehicle. When at high-speed vehicle brake has a very important role. The purpose of this study was to investigate the influence of the environment in the form of spraying ...
, Supriyono, ST, MT, Ph.D, , Wijianto, ST, M.Eng, Sc., Syafaruddin, Agus   +2 more
core   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

Characterization of Brake Pads by Variation in Composition of Friction Materials [PDF]

, 2014
Brake pads are the most important component of an automobile braking system. It help in smooth retardation of a vehicle and finally bringing it to halt. Brake pads convert the vehicle's kinetic energy into thermal energy by friction. The effectiveness of
Siddaraju, C., Prakash, S.V., Ramesh, M.R., Nagesh, S.N.   +3 more
core   +1 more source

Fueling Tomorrow: Scenario Planning for the Future of Gas Stations

Business Strategy and the Environment, EarlyView.
ABSTRACT Transport electrification is reshaping the service infrastructures that mediate everyday mobility, yet most electrification scenario studies remain macrolevel and offer limited insight into how incumbent forecourt (gas‐station) networks can adapt under deep uncertainty.
Joao Gabriel Rosa, Fabiano Armellini, Jean‐Marc Robert   +2 more
wiley   +1 more source

The effect of the brake pad components to the some physical properties of the ecological brake pad samples

IOP Conference Series: Materials Science and Engineering, 2017
In this study, brake pad components in powder form such as miscanthus, cashew, alumina, phenolic resin and calcite, were used to manufacture ecological brake pads. In the brake pad applications trial and error method is often used to find the optimum proportion providing the best characteristics of the component in composite.
Unaldi, Mahmut, Kus, Recai
openaire   +2 more sources