Results 31 to 40 of about 3,864 (261)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Optimal allocation method of electric/air braking force of high-speed train considering axle load transfer

High-Speed Railway
Reasonable distribution of braking force is a factor for a smooth, safe, and comfortable braking of trains. A dynamic optimal allocation strategy of electric-air braking force is proposed in this paper to solve the problem of the lack of consideration of
Feng Guo, Jing He
doaj   +1 more source

Research on Electronic Brake Force Distribution and Anti-Lock Brake of Vehicle Based on Direct Drive Electro Hydraulic Actuator

International Journal of Automotive Engineering, 2020
In order to effectively improve the vehicle safety, this paper proposed an electronic brake force distribution scheme and an anti-lock brake scheme for passenger car based on a novel brake-by-wire system. The brake-by-wire system was introduced at first,
Xiaoxiang Gong, Lixia Qian, Weiguo Ge, Juan Yan   +3 more
doaj   +1 more source

About Braking of Wheeled Vehicle Equipped with Automated Brake Control System

Наука и техника, 2022
The paper proposes a method for determining a vehicle stopping distance based on a braking rate and a coefficient of using an adhesion force by an automated control system for regulating a braking force on the example of a multi-axle vehicle.
D. N. Leontiev, V. A. Bogomolov, V. I. Klymenko, L. A. Ryzhyh, S. I. Lomaka, A. V. Suhomlin, A. V. Kuripka, A. A. Frolov   +7 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Three‐Dimensional Anomalous Hall Sensing Enabled By Spin–Orbit Torque Driven Domain Reconfiguration In Chiral Multilayers

Advanced Functional Materials, EarlyView.
A three‐dimensional magnetic field sensor is realized in chiral W/CoFeB/MgO multilayers, where spin–orbit torques reversibly reconfigure homochiral stripe domains. The symmetry of the torque enables offset‐free in‐plane sensing, while the reproducible domain reconfiguration extends the linear out‐of‐plane range. An anomalous Hall readout delivers large‐
Sabri Koraltan, Rahul Gupta, Reshma Peremadathil Pradeep, Fabian Kammerbauer, Iryna Kononenko, Klemens Prügl, Michael Kirsch, Bernd Aichner, Santiago Helbig, Florian Bruckner, Claas Abert, Andrada Oana Mandru, Armin Satz, Gerhard Jakob, Hans Josef Hug, Mathias Kläui, Dieter Suess   +16 more
wiley   +1 more source

From Fiber Bundles to Architected Membranes: Triply Periodic Minimal Surface Architectures for Biohybrid Artificial Lungs

Advanced Materials, EarlyView.
Additively manufactured triply periodic minimal surface (TPMS) membranes offer an architecture‐driven alternative to hollow fiber bundles in artificial lungs. Multiphysics simulations and endothelialized prototypes show that the 3D‐printable membrane architecture improves gas exchange, blood flow distribution, and hemocompatibility, enabling ...
Michael Pflaum, Kai P. Barbian, Florian Neuhaus, Gerrit Sitarz, Carolin Nölke, Sebastian V. Jansen, John Linkhorst, Lukas T. Hirschwald, Sebastian Brosch, Christian Certa, Ulrich Steinseifer, Matthias Wessling, Jutta Arens, Arjang Ruhparwar, Bettina Wiegmann   +14 more
wiley   +1 more source

Tram Whole-Train Braking Force Management Strategy Based on TCMS

Chengshi guidao jiaotong yanjiu
[Objective] Trams require high braking performance and reliability, but they cannot achieve unified distribution and management of the whole train′s braking force.
XU Jie, YANG Chuan, MA Xuan
doaj   +1 more source

Integrated control of braking-yaw-roll stability under steering-braking conditions

Scientific Reports, 2023
Sharp steering-braking at a high speed exposes sport utility vehicles with high gravity centers and narrow wheel tracks to the risks of tire locking, sideslip and rollover.
Jia Chen, Yihang Liu, Renping Liu, Feng Xiao, Jian Huang   +4 more
doaj   +1 more source

Regenerative Braking Strategy of Dual-Motor EV Considering Energy Recovery and Brake Stability

World Electric Vehicle Journal, 2023
The dual-motor EV (Electric Vehicle) is increasingly favored by manufacturers for its excellent performance in terms of power and economy. How to further reduce its energy consumption and make full use of the dual-motor energy recovery is an important ...
Tonglie Wu, Feng Wang, Peng Ye
doaj   +1 more source