Results 61 to 70 of about 3,864 (261)

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

USING COUPLING WEIGHTS AND RATIONAL DISTRIBUTION OF BRAKE FORCES BETWEEN THE AXLES OF WHEELED VEHICLES [PDF]

Avtomobilʹnyj Transport (Harʹkov), 2011
The dependence of the coefficient of coupling weight-axle vehicles under braking and a ra-tional distribution coefficient of braking force to the front axle on the condition of maximum coupling weight.
M. Kholodov, M. Podrigalo
doaj  

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

IDEAL BRAKE FORCE DISTRIBUTION BETWEEN THE AXLES OF THE TWO-AXLE VEHICLE SERVICE BRAKE APPLICATIONS [PDF]

Avtomobilʹnyj Transport (Harʹkov), 2015
The obtained analytical expressions allow us to evaluate the stability of two-axle vehicles at various slowdowns. An analytical expression for calculating the ideal according to condition stability ensuring of a two-axle vehicle at service brake ...
M. Podryhalo, A. Turenko
doaj  

Design Explorations on the Brake Force Distributions of a Motorbike

Journal of Applied Engineering Design and Simulation
The braking system is crucial for motorbike safety, as effective braking ensures both deceleration and stability. This study investigates the influence of the deceleration rate and the combined biker and pillion load on the optimal distribution of the braking force of a motorbike.
Mahamad Hisyam Mahamad Basri, Noor Iswadi Ismail, Muhammad Arif AB Hamid Pahmi, Rosniza Rabilah, Hazim Sharudin   +4 more
openaire   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source

Analysis of the Braking Performance of the Hydraulic Retarder in Mining Dump Truck based on AMESim

Jixie chuandong, 2016
The hydrodynamic retarder is one of the important auxiliary braking system in mining dump truck,which has an important influence on the braking force distribution and braking performance of the vehicle.
Deng Lin
doaj  

Composite Braking Control Strategy for Electromechanical-Hydraulic Vehicles

CSEE Journal of Power and Energy Systems
Short driving ranges and low braking energy recovery efficiencies are two recognized technical bottlenecks to be overcome in electric vehicles. In this paper, a novel electromechanical-hydraulic coupling system is proposed and integrated as a powertrain ...
Zewen Meng, Jichao Hong, Hongxin Zhang, Tiezhu Zhang, Xiaoming Xu, Qinghai Zhao, Jian Yang   +6 more
doaj   +1 more source

Interfacial Electric Field Engineering of High‐Entropy Heterostructures Triggering Self‐Limiting Reconstruction for Industrial‐Scale Electrocatalysis

Advanced Science, EarlyView.
An interfacial electric field engineering strategy is proposed to trigger the self‐limiting surface reconstruction of high‐entropy heterostructures. Driven by this built‐in field, the controlled sacrificial leaching of W evolves a robust active layer, enabling exceptional oxygen evolution performance and ultrastability at ampere‐level current densities
Liang Yan, Yueqi Zhang, Bing Zhang, Jingyi Ye, Hao Li   +4 more
wiley   +1 more source