Results 101 to 110 of about 120,905 (338)

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

open access: yesAdvanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo   +5 more
wiley   +1 more source

The enigmatic spin evolution of PSR J0537-6910: r-modes, gravitational waves and the case for continued timing

open access: yes, 2017
We discuss the unique spin evolution of the young X-ray pulsar PSR J0537-6910, a system in which the regular spin down is interrupted by glitches every few months.
Andersson, N.   +4 more
core   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto   +20 more
wiley   +1 more source

Design and verification of novel powertrain management for multi-geared battery electric vehicles [PDF]

open access: yes, 2016
University of Technology Sydney. Faculty of Engineering and Information Technology.Despite the long-term benefit of battery electric vehicles (BEVs) to customers and the environment, the initial cost and limited driving range present the significant ...
Ruan, Jiageng
core  

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

open access: yesAdvanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang   +15 more
wiley   +1 more source

The Evaluation of Braking Performances of Mechanical Brake System on Oil Rig

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2013
This paper proposes a novel method for evaluating the braking system on oil rig. The Evaluation indexes, braking capacity, response speed control accuracy and braking efficiency, are put forward according to the drilling safety, benefit, quality and so ...
Yu WANG, Li LIN
doaj   +1 more source

Behavior of aircraft antiskid breaking systems on dry and wet runway surfaces: A slip-ratio-controlled system with ground speed reference from unbraked nose wheel [PDF]

open access: yes
An experimental investigation was conducted at the Langley aircraft landing loads and traction facility to study the braking and cornering response of a slip ratio controlled aircraft antiskid braking system with ground speed reference derived from an ...
Stubbs, S. M., Tanner, J. A.
core   +1 more source

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