Results 151 to 160 of about 67,993 (243)

Association of circulating branched-chain amino acids with risk of pre-diabetes: a systematic review and meta-analysis. [PDF]

PeerJ
Wang Y, Xiao JH, Zhang XM, Wang WX, Zhang Q, Tang YP, Yue SJ.   +6 more
europepmc   +1 more source

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Tissue-Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched-Chain Amino Acids. [PDF]

Aging Cell
Calubag MF, Ademi I, Grunow ID, Breuer LE, Babygirija R, Lialios P, Le SM, Sonsalla MM, Illiano JA, Knopf BA, Xiao F, Minton D, Konopka AR, Harris DA, Lamming DW.   +14 more
europepmc   +1 more source

An Enzyme‐Like Catalyzed Nanosheets for Redox Stress Oscillation Therapy Against Bacterial Infections

Advanced Science, EarlyView.
Bacterial biofilms form a physicochemical barrier. Their dense network structure and redox homeostasis confer high resistance to antimicrobial treatments and immune‐mediated killing and clearance. In this study, SnSe nanosheets with enzyme‐like properties and piezoelectric catalysis can oscillate to regulate bacterial redox homeostasis and improve the ...
Min Ge, Zhao Guo, Zhiming Zhang, Lanlu Lu, Zesong Ruan, Tingwang Shi, Yunfeng Chen, Ju Huang, Chaoliang Tan, Han Lin   +9 more
wiley   +1 more source

Bidirectional Mendelian Randomization Indicates Causal Relationships Between Circulating Branched-Chain Amino Acids and Metabolic Health. [PDF]

Diabetes
Jia RY, Chen JH, Lockhart S, Lam BYH, Kentistou KA, Zhao Y, Gardner EJ, Perry JRB, O'Rahilly S, Day FR, Ong KK.   +10 more
europepmc   +1 more source

Single‐Cell Transcriptomic Atlases of Camels and Cattle Unravel Molecular Evolution of Digestive and Metabolic Systems

Advanced Science, EarlyView.
We generated multi‐tissue single‐cell transcriptomic atlases of camels and cattle, uncovering conserved and lineage‐specific cellular features across digestive and metabolic systems. Cross‐species comparisons revealed the evolutionary origin of the camel glandular sac and identified novel cell populations linked to physiological specialization ...
Tao Shi, Huiquan Shan, Haoping Wang, Xi Guo, Houcheng Li, Bo Han, Senlin Zhu, Fei Wang, Guanghui Tan, Zhannur Niyazbekova, Jilong Ren, Yaqi Zhou, Qi Zhang, Weijie Zheng, Minghui Jia, Ao Zhang, Xuesha Cao, Huizeng Sun, Dongxiao Sun, Lingzhao Fang, Yi Zheng, Xihong Wang, Yu Jiang   +22 more
wiley   +1 more source

Assessment of genetic and metabolite associations of branched chain amino acids with metabolic disease in the UK Biobank using Mendelian randomization. [PDF]

BMC Med Genomics
Konarkowski J, Astore C, Gibson G.
europepmc   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Effects of branched-chain amino acids on the muscle-brain metabolic axis: enhancing energy metabolism and neurological functions, and endurance exercise in aging-related conditions. [PDF]

Front Nutr
Wu J.
europepmc   +1 more source

Branched-chain Amino Acid Supplement [PDF]

, 2020
openaire   +1 more source