Results 171 to 180 of about 70,347 (257)

Early Supplementation with Branched-Chain Amino Acids Ameliorates Lipid Retention in Aortic Valves of ApoE-Knockout Mice. [PDF]

Int J Mol Sci
Shishkova D, Kanonykina A, Kondratiev E, Tyurina A, Morozova A, Poddubnyak A, Sinitskaya A, Sinitsky M, Markova V, Lazebnaya A, Bogdanov L, Stepanov A, Agalaryan S, Kutikhin A.   +13 more
europepmc   +1 more source

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +2 more sources

Association of circulating branched-chain amino acids with risk of pre-diabetes: a systematic review and meta-analysis. [PDF]

PeerJ
Wang Y, Xiao JH, Zhang XM, Wang WX, Zhang Q, Tang YP, Yue SJ.   +6 more
europepmc   +1 more source

Tissue-Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched-Chain Amino Acids. [PDF]

Aging Cell
Calubag MF, Ademi I, Grunow ID, Breuer LE, Babygirija R, Lialios P, Le SM, Sonsalla MM, Illiano JA, Knopf BA, Xiao F, Minton D, Konopka AR, Harris DA, Lamming DW.   +14 more
europepmc   +1 more source

Dissecting the relationship between hypertensive disorders of pregnancy and branched-chain amino acids: An integrated investigation combining Mendelian randomization, transcriptomics, and machine learning. [PDF]

Medicine (Baltimore)
Zheng Y, Qin D, Zhang X, Sun H, Fei W, Yao Y.   +5 more
europepmc   +1 more source

Bidirectional Mendelian Randomization Indicates Causal Relationships Between Circulating Branched-Chain Amino Acids and Metabolic Health. [PDF]

Diabetes
Jia RY, Chen JH, Lockhart S, Lam BYH, Kentistou KA, Zhao Y, Gardner EJ, Perry JRB, O'Rahilly S, Day FR, Ong KK.   +10 more
europepmc   +1 more source

Assessment of genetic and metabolite associations of branched chain amino acids with metabolic disease in the UK Biobank using Mendelian randomization. [PDF]

BMC Med Genomics
Konarkowski J, Astore C, Gibson G.
europepmc   +1 more source

Effects of branched-chain amino acids on the muscle-brain metabolic axis: enhancing energy metabolism and neurological functions, and endurance exercise in aging-related conditions. [PDF]

Front Nutr
Wu J.
europepmc   +1 more source

Effect of Growth Hormone on Branched-Chain Amino Acids Catabolism in Males With Hypopituitarism. [PDF]

J Cell Mol Med
Zhang Y, Ye Z, Xiang E, Chen P, Fang X.
europepmc   +1 more source

Unveiling the Maze: Branched-Chain Amino Acids Fueling the Dynamics of Cancer Metabolism and Progression. [PDF]

Cancers (Basel)
Xu K, Shah P, Makhanasa D, Khan MW.
europepmc   +1 more source