Advanced Science, EarlyView.TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao +8 more
wiley +1 more source
Bidirectional Mendelian Randomization Indicates Causal Relationships Between Circulating Branched-Chain Amino Acids and Metabolic Health. [PDF]
DiabetesJia RY +10 more
europepmc +1 more source
Gel Electrolytes for Flexible Zinc‐Air Batteries: Design, Challenges, and Perspectives
Advanced Science, EarlyView.This review summarizes design strategies for gel electrolytes in flexible zinc‐air batteries, focusing on dendrite suppression, interfacial stability, and ultrathin architectures to enhance cycle life and energy density. ABSTRACT Flexible zinc‐air batteries (FZABs) have emerged as promising candidates for next‐generation flexible electronics and large ...
Yapeng Cao +5 more
wiley +1 more source
Assessment of genetic and metabolite associations of branched chain amino acids with metabolic disease in the UK Biobank using Mendelian randomization. [PDF]
BMC Med GenomicsKonarkowski J, Astore C, Gibson G.
europepmc +1 more source
Advanced Science, EarlyView.A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen +5 more
wiley +1 more source
Effect of Growth Hormone on Branched-Chain Amino Acids Catabolism in Males With Hypopituitarism. [PDF]
J Cell Mol MedZhang Y, Ye Z, Xiang E, Chen P, Fang X.
europepmc +1 more source
Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy
Advanced Science, EarlyView.This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao +5 more
wiley +1 more source
Effects of branched-chain amino acids on the muscle-brain metabolic axis: enhancing energy metabolism and neurological functions, and endurance exercise in aging-related conditions. [PDF]
Front NutrWu J.
europepmc +1 more source
Beyond PEG: Emerging Polymer Lipid Alternatives for Lipid Nanoparticle (LNP) Formulations
Advanced Science, EarlyView.This review discusses recent advances in PEG‐alternative LNP designs, including non‐PEG polymers, zwitterionic lipids, and polypeptides. It evaluates how surface‐engineering chemistry influences LNP formation and biological behavior, and highlights current limitations and opportunities of PEG‐alternative LNPs.
Zihnil A. I. Mazrad +4 more
wiley +1 more source
Unveiling the Maze: Branched-Chain Amino Acids Fueling the Dynamics of Cancer Metabolism and Progression. [PDF]
Cancers (Basel)Xu K, Shah P, Makhanasa D, Khan MW.
europepmc +1 more source