Dissecting the relationship between hypertensive disorders of pregnancy and branched-chain amino acids: An integrated investigation combining Mendelian randomization, transcriptomics, and machine learning. [PDF]
Zheng Y +5 more
europepmc +1 more source
Appropriate butylene oxide (BO) functionalization of amines (polyethyleneimine (PEI1200 and PEI300) and tris(2‐aminoethyl)amine (TREN)) enables excellent cyclic working capacities (WCcyclic) at low desorption temperatures (40−70°C). Notably, 0.30BO‐PEI300‐SY and 0.54BO‐TREN‐SY show the highest WCcyclic at 45 and 40°C, respectively.
Joo Yeon Han +10 more
wiley +1 more source
Tissue-Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched-Chain Amino Acids. [PDF]
Calubag MF +14 more
europepmc +1 more source
Advanced Dental Composite Technology via Bisilanized Dual‐Action Nanofillers for Biofilm Control
A multimodal research strategy has led to the development of an innovative resin‐based composite (RBC) with dual antibacterial action. The S_CM‐RBC formula showed strong antibiofilm activity, excellent mechanical strength, and biosafety. It effectively controlled oral bacteria in prevention of caries recurrence, and maintained pulp health in a rat ...
Chenmin Yao +11 more
wiley +1 more source
Bidirectional Mendelian Randomization Indicates Causal Relationships Between Circulating Branched-Chain Amino Acids and Metabolic Health. [PDF]
Jia RY +10 more
europepmc +1 more source
Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance
Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes +4 more
wiley +1 more source
Assessment of genetic and metabolite associations of branched chain amino acids with metabolic disease in the UK Biobank using Mendelian randomization. [PDF]
Konarkowski J, Astore C, Gibson G.
europepmc +1 more source
Programmable hydration pathways enable reconfigurable ionic thermoelectrics in polyquaternium hydrogels. By coupling microscopic solvation, mesoscale water channels, and macroscopic boundary control, hydration‐gated protonics decouples thermopower, response speed, and stability.
Zehao Zhao, Yun Shen, Dongyan Xu
wiley +1 more source
Effects of branched-chain amino acids on the muscle-brain metabolic axis: enhancing energy metabolism and neurological functions, and endurance exercise in aging-related conditions. [PDF]
Wu J.
europepmc +1 more source

