Results 201 to 210 of about 70,776 (261)

Association between dietary animal-derived branched-chain amino acids and sarcopenia in older adults: a cross-sectional study based on Chinese community. [PDF]

Front Nutr
Zhang T, Zhang C, Du H, Chang Y, Zhao K, Xue H, Liang M, Li Z.   +7 more
europepmc   +1 more source

Generalizable Strategies for the Synthesis of Cereblon‐Recruiting PROTAC Prodrugs

Angewandte Chemie, EarlyView.
Cereblon‐recruiting PROTACs remain challenging to derivatize for prodrug‐based delivery. In this study, three complementary conjugation strategies enabled the efficient synthesis of cleavable PROTAC prodrugs with tunable release kinetics that can be incorporated into a library of PEGylated constructs and bottlebrush prodrugs.
Aiden X. Wang, Bin Liu, Elise M. Ackerman, Yichen Xiang, Hung V.‐T. Nguyen, Yivan Jiang, Angela N. Koehler, Jeremiah A. Johnson   +7 more
wiley   +1 more source

Branched-Chain Amino Acids and Inflammation Management in Endurance Sports: Molecular Mechanisms and Practical Implications. [PDF]

Nutrients
Xu M, Hu D, Liu X, Li Z, Lu L.
europepmc   +1 more source

Downsizing the Histone H3–H4 Quaternary Structure Into Foldamer Mimetics Yields High‐Affinity and Cell‐Permeable Ligands of ASF1

Angewandte Chemie, EarlyView.
We present a foldamer strategy to downsize the histone H3‐H4 quaternary structure into high‐affinity, medium‐sized binders (∼2 kDa) for the histone chaperone ASF1. Our peptide‐oligourea chimeras, designed through structure‐guided optimization and foldamer chemistry, recapitulate the natural H3‐H4 dimer binding mode while demonstrating plasma stability ...
Bo Li, Marie E. Perrin, Emma Maillard, Arthur Vitard, Gwenaëlle Moal, Johanne Mbianda, Christophe André, Magda Teixeira Nunes, Marie Vandamme, Guillaume Pinna, Céline Douat, Emmanuelle Thinon, Raphaël Guerois, Pierre Legrand, Gilles Guichard, Francoise Ochsenbein   +15 more
wiley   +1 more source

The Effect of Acute Supplementation of Branched Chain Amino Acids on Serum Metabolites During Endurance Exercise in Healthy Young Males: An Integrative Metabolomics and Correlation Analysis Based on a Randomized Crossover Study. [PDF]

Metabolites
Zhang X, Wang X, Luan C, Wang Y, Li J, Shan W, Ni Z, Xu C, Gong L.   +8 more
europepmc   +1 more source

Branched-chain amino acids contribute to diabetic kidney disease progression via PKM2-mediated podocyte metabolic reprogramming and apoptosis. [PDF]

Nat Commun
Zhao H, Sun D, Wang S, Liu Y, Zhao X, Tian W, Dou X, Liu J, Xu J, Peng L, Sun S, Xia Y, Xu X, Wang C, Wang D, Zhao G, Wang X, Weng H, Ding F, Xing P, Zhang F, Liu S, Yan W, Tao L.   +23 more
europepmc   +1 more source

Quantum chemical study of molecular properties of small branched-chain amino acids in water. [PDF]

Amino Acids
Boča R, Rádiková Ž, Štofko J, Vranovičová B, Rajnák C.   +4 more
europepmc   +1 more source

Branched-chain amino acids induce hyperammonemia via gut-liver axis-mediated ammonia overproduction in laying hens. [PDF]

Anim Nutr
Jian H, Xu M, Liu F, Zhang L, Huang Q, Ma J, Zou X, Dong X.   +7 more
europepmc   +1 more source

Circulating branched-chain amino acids and the risk of major adverse cardiovascular events in the UK biobank. [PDF]

Front Endocrinol (Lausanne)
Sun W, Lin R, Li Y, Yao Y, Lu B, Yu Y.
europepmc   +1 more source