Results 91 to 100 of about 38,022 (189)

Single-cell multiomics analysis reveals CTCF as a key regulator of lung morphogenesis and progenitor maintenance

Nature Communications
Lung development generates a complex tree-like architecture through proximal-distal patterning and branching morphogenesis. However, the gene regulatory programs governing embryonic lung development remain poorly understood.
Shenfei Sun, Yamei Jiang, Fujing Huang, Wei Wei, Mathias Hochgerner, Tianmin Xu, Xiaoting Wang, Kaijun Lin, Xinna Zhang, Yanli Wang, Hua He, Miao Yu, Xiaofang Tang, Xinhua Lin   +13 more
doaj   +1 more source

ISL1 regulates lung branching morphogenesis via Shh signaling pathway. [PDF]

J Biol Chem, 2023
Huang R, Zhang C, Zheng Y, Zhang W, Huang H, Qiu M, Li J, Li F.   +7 more
europepmc   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Loss of POGLUT2/3‐mediated O‐glucosylation produces lung and aortic phenotypes reminiscent of fibrillin1 mutants

Developmental Dynamics, EarlyView.
Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane, Angelina Almiroudis, Kaitlyn E. Donnelly, Robert S. Haltiwanger, Bernadette C. Holdener   +4 more
wiley   +1 more source

A shining starlet: Nematostella vectensis as a model for developmental, regenerative, and comparative biology

Developmental Dynamics, EarlyView.
Abstract The sea anemone, Nematostella vectensis, has been used as a model organism in developmental biology studies for many years. This estuarine species has the notable capacity to regenerate its full body plan from small pieces throughout life. Nematostella have been described as having a great degree of cellular plasticity.
Patrick A. Lewis, Zachary Horowitz, Michael Shribak, Karen Echeverri   +3 more
wiley   +1 more source

Zebrafish ventral gastrula fate map reveals neural crest progenitor domain

Developmental Dynamics, EarlyView.
Abstract Background Fate maps relate progenitor cell positions to later fates and locations of their progeny, revealing early embryonic organization. Previous zebrafish fate maps identified the origin of germ layers and derivative cell fates, but ventral gastrula progenitor domains were not fully resolved. In particular, the neural crest, a multipotent
Elaine E. Kushkowski, Victoria E. Prince
wiley   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

PRDM16 is necessary for sensory neuronal development and differentiation in the trigeminal ganglion

Developmental Dynamics, EarlyView.
Abstract Background Cranial neural crest cells (cNCC) generate craniofacial cartilage, bone, and peripheral neurons and glia, and birth defects arise when the cartilage/neuronal/glial progenitors fail to differentiate. PRDM16 is a transcriptional regulator containing both zinc‐finger and SET domains, implicated in craniofacial development and orofacial
Fahmida Raha, Qiman Gao, Lomeli C. Shull, Kristin B. Artinger   +3 more
wiley   +1 more source

Evidence for functional convergence between LZTS2 and DYRK1A during craniofacial development

Developmental Dynamics, EarlyView.
Abstract Background Precise control of DYRK1A dosage is essential for embryonic development, including craniofacial morphogenesis. While LZTS2 is among the most consistently identified DYRK1A‐interacting proteins, its roles in embryonic development remain incompletely understood, and its potential contribution to craniofacial development has not been ...
Nicole Cheng, Santiago Lima, Larisa Litovchick, Amanda J. G. Dickinson   +3 more
wiley   +1 more source

Cellular diversity of the developing chick trigeminal ganglion at single‐cell resolution

Developmental Dynamics, EarlyView.
Abstract Background The trigeminal ganglion (TG) integrates sensory input from the face and jaw and is derived from two embryonic cell populations: neural crest and cranial placode. These populations interact during TG development to coordinate specification, differentiation, and organization, but the molecular characteristics of the heterogeneous cell
Arvind Arul Nambi Rajan, Erica J. Hutchins   +1 more
wiley   +1 more source