Results 71 to 80 of about 489,624 (317)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Melatonin inhibits embryonic salivary gland branching morphogenesis by regulating both epithelial cell adhesion and morphology. [PDF]

PLoS ONE, 2015
Many organs, including salivary glands, lung, and kidney, are formed by epithelial branching during embryonic development. Branching morphogenesis occurs via either local outgrowths or the formation of clefts that subdivide epithelia into buds.
Aya Obana-Koshino, Hitomi Ono, Jiro Miura, Manabu Sakai, Hitoshi Uchida, Wataru Nakamura, Kanji Nohara, Yusuke Maruyama, Atsuhiko Hattori, Takayoshi Sakai   +9 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Double radiative pion capture on hydrogen and deuterium and the nucleon's pion cloud

, 2007
We report measurements of double radiative capture in pionic hydrogen and pionic deuterium. The measurements were performed with the RMC spectrometer at the TRIUMF cyclotron by recording photon pairs from pion stops in liquid hydrogen and deuterium ...
C. J. Batty, D. H. Wright, D. S. Armstrong, D. W. Joseph, H. Brafman, H. W. Baer, J. H. D. Clark, L. I. Lapidus, L. I. Lapidus, M. A. Kovash, M. D. Hasinoff, M. E. Christy, P. A. Zołnierczuk, S. Tripathi, T. P. Gorringe   +14 more
core   +1 more source

The branching process with logistic growth [PDF]

, 2005
In order to model random density-dependence in population dynamics, we construct the random analogue of the well-known logistic process in the branching process' framework.
Lambert, Amaury
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Criticality for branching processes in random environment

, 2005
We study branching processes in an i.i.d. random environment, where the associated random walk is of the oscillating type. This class of processes generalizes the classical notion of criticality.
Afanasyev, V. I., Geiger, J., Kersting, G., Vatutin, V. A.   +3 more
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

On the Critical Parameters of Branching Random Walks

Mathematics
Given a discrete spatial structure X, we define continuous-time branching processes {ηt}t≥0 that model a population breeding and dying on X. These processes are usually called branching random walks, and ηt(x) denotes the number of individuals alive at ...
Daniela Bertacchi, Fabio Zucca
doaj   +1 more source

Viral Evolution and Adaptation as a Multivariate Branching Process

, 2013
In the present work we analyze the problem of adaptation and evolution of RNA virus populations, by defining the basic stochastic model as a multivariate branching process in close relation with the branching process advanced by Demetrius, Schuster and ...
Antoneli, Fernando, Bosco, Francisco, Castro, Diogo, Janini, Luiz Mário Ramos, Mondaini, R. P.   +4 more
core   +1 more source