Results 71 to 80 of about 913,345 (341)
FEBS Letters, Volume 599, Issue 6, Page 901-911, March 2025.The human Na+/H+ antiporter NHA2 transports Na+ or Li+ in exchange for protons across cell membranes, and its dysfunction results in various pathologies, e.g., fertility disorders, hypertension, or diabetes. This work provides the molecular characterization of interactions of NHA2 with its specific inhibitor phloretin, which can be helpful for the ...
Olga Zimmermannova +3 more
wiley +1 more source
Network-based analysis of a small Ebola outbreak
Mathematical Biosciences and Engineering, 2017 We present a method for estimating epidemic parameters in network-based stochastic epidemic models when the total number of infections is assumed to be small. We illustrate the method by reanalyzing the data from the 2014 Democratic Republic of the Congo
Mark G. Burch +3 more
doaj +1 more source
A Branching Process for Virus Survival [PDF]
Journal of Applied Probability, 2012 Quasispecies theory predicts that there is a critical mutation probability above which a viral population will go extinct. Above this threshold the virus loses the ability to replicate the best-adapted genotype, leading to a population composed of low replicating mutants that is eventually doomed.
Cox, J. Theodore, Schinazi, Rinaldo B
openaire +4 more sources
Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones
FEBS Letters, Volume 599, Issue 9, Page 1269-1284, May 2025.Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley +1 more source
Immunoregulatory mechanisms of the arachidonic acid pathway in cancer
FEBS Letters, Volume 599, Issue 7, Page 927-951, April 2025.The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine +3 more
wiley +1 more source
Genome Biology, 2018 High-throughput single-cell gene expression experiments can be used to uncover branching dynamics in cell populations undergoing differentiation through pseudotime methods.
Alexis Boukouvalas +2 more
doaj +1 more source
The control of branching morphogenesis [PDF]
Open Biology, 2013 Many organs of higher organisms are heavily branched structures and arise by an apparently similar process of branching morphogenesis. Yet the regulatory components and local interactions that have been identified differ greatly in these organs. It is an
Dagmar Iber, Denis Menshykau
doaj +1 more source
Alternating branching processes [PDF]
Journal of Applied Probability, 2005 We introduce the idea of controlling branching processes by means of another branching process, using the fractional thinning operator of Steutel and van Harn. This idea is then adapted to the model of alternating branching, where two Markov branching processes act alternately at random observation and treatment times.
openaire +2 more sources
Branching Bisimilarity Checking for PRS
, 2014 Recent studies reveal that branching bisimilarity is decidable for both nBPP (normed Basic Parallel Process) and nBPA (normed Basic Process Algebra).
Fu, Yuxi +4 more
core +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source