Results 131 to 140 of about 386,927 (307)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Collective Value Creation and Empowerment in an Online Brand Community: A Netnographic Study on LEGO Builders [PDF]
Technology Innovation Management Review, 2012 Online communities are becoming “places” of belonging, information, and emotional support that people cannot do without. These social groups have a real existence for their participants, and thus have consequential effects on many aspects of behaviour ...
Pekka Tuominen, Hanna Kurikko
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Assessment of Impact of Global Business Environment on International Tourism Brands [PDF]
, 2017 In the article the concept of modern International tourism is considered. The certain estimation of influence of global factors of business-environment on the process of forming of International tourist brand of countries is presented.
Kucherenko, K. (Ksenia)
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
GALACTICOIN: A new revenue stream for Real Madrid based on blockchain technology [PDF]
, 2018 White paper.SUMMARY: Football is indeed a beautiful game, and its appeal is unrivaled. This industry continues its pace as one of the fastest markets in the world and during the last years, the way clubs interact and engage with the fans has changed ...
Patrucco, Fiorella, Wölfel, Kim
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Pengaruh Co-Creation terhadap Brand Awareness
Jurnal Informatika Ekonomi BisnisThe purpose of this study was to determine the effect of Co-Creation between Dermies Hello Glow by ERHA and Teh Botol Sosro on Brand Awareness of Dermies Hello Glow by ERHA products. The respondents studied were Indonesian women who use skincare products. The purposive sampling method was used for research sampling.
Sifa Fauziyyah, Rizqi Muttaqin
openaire +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source