Results 151 to 160 of about 100,457 (283)

The impact of blockchain adoption on supply chain financing and E-commerce platform dynamics. [PDF]

PLoS One
Pi S.
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Reference Pricing of Pharmaceuticals [PDF]

We consider a therapeutic market with potentially three pharmaceutical firms. Two of the firms offer horizontally differentiated brand-name drugs. One of the brand-name drugs is a new treatment under patent protection that will be introduced if the ...
Ingrid Königbauer, Kurt R. Brekke, Odd Rune Straume   +2 more
core  

Online Auction Design Using Distribution-Free Uncertainty Quantification with Applications to E-Commerce. [PDF]

J Am Stat Assoc
Han J, Dai X.
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Hedonic Analysis of Sustainable Food Products [PDF]

hedonic, sustainable, sustainability, eggs, free-range, cage-free, Agribusiness, Q13,
Satimanon, Thasanee, Weatherspoon, Dave D.   +1 more
core   +1 more source

Operant demand for cigarettes varies by unit of purchase: Comparing purchasing of packs and individual cigarettes. [PDF]

Exp Clin Psychopharmacol
Reed DD, Graham ME, Gelino BW, Strickland JC.   +3 more
europepmc   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Democracy in product design: Consumer participation and differentiation strategies [PDF]

, 2015
Katona, Zsolt
core   +1 more source

An Evaluation of the Home Consumption Value System [PDF]

The Philippines has been one among the few that still adheres to the home consumption valuation (HCV), a system that, according to many importers, results to overvaluation.
Aldaba, Rafaelita M., de Dios, Loreli C., Medalla, Erlinda M.   +2 more
core