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BRCA1 regulation of transcription
Cancer Letters, 2006BRCA1, a tumor suppressor gene on chromosome 17q21, was identified in 1994 based on its linkage to hereditary breast and ovarian cancer syndromes. The BRCA1 gene encodes a 220 kDa nuclear phosphoprotein. Studies aimed at elucidating the mechanisms of its tumor suppressor activity have revealed, in part, that BRCA1 participates in the DNA damage ...
Eliot M, Rosen +2 more
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Journal of Cancer Research and Clinical Oncology, 1997
More than 100 mutations have been described for the breast-cancer-susceptibility gene BRCA1. The paper describes phenotypical aspects of three selected mutations located at the beginning, in the middle, and at the end of the gene. A remarkable decrease of the age of diagnosis of the mammary carcinoma is observed with increasing length of the putative ...
K, Grade +5 more
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More than 100 mutations have been described for the breast-cancer-susceptibility gene BRCA1. The paper describes phenotypical aspects of three selected mutations located at the beginning, in the middle, and at the end of the gene. A remarkable decrease of the age of diagnosis of the mammary carcinoma is observed with increasing length of the putative ...
K, Grade +5 more
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New England Journal of Medicine, 2010
The cellular machinery that transports BRCA1 protein to sites of DNA repair is critical to DNA integrity. Two recent studies have identified key components of this machinery.
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The cellular machinery that transports BRCA1 protein to sites of DNA repair is critical to DNA integrity. Two recent studies have identified key components of this machinery.
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2021
Aims. Breast cancer ranks first among cancers of the female population in Ukraine and in most countries abroad. However, data on the mutations frequencies in Ukraine for BRCA1 gene is limited. We investigated the variation and frequency of mutations in gene BRCA1 among patients with breast cancer in three regions of Ukraine. Methods.
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Aims. Breast cancer ranks first among cancers of the female population in Ukraine and in most countries abroad. However, data on the mutations frequencies in Ukraine for BRCA1 gene is limited. We investigated the variation and frequency of mutations in gene BRCA1 among patients with breast cancer in three regions of Ukraine. Methods.
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The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication
Nature Reviews Molecular Cell Biology, 2020Madalena Tarsounas, Patrick Sung
exaly