Results 291 to 300 of about 143,588 (347)

Loss of CHTF18-RFC2/5 leads to replicative gaps and sensitivity to PARP inhibitors. [PDF]

NAR Cancer
Buckley-Benbow L, Ozgencil M, Tardocchi A, Agnarelli A, Bellelli R.   +4 more
europepmc   +1 more source

BRCA1 and BRCA2 pathogenic variants increase the risk of four less common cancer types. [PDF]

ESMO Open
Sasagawa H, Endo M, Iwasaki Y, Usui Y, Koyanagi YN, Innella G, Hadler J, Parsons MT, Numakura K, Kamatani Y, Murakami Y, Matsuo K, Matsuda K, Spurdle AB, Habuchi T, Momozawa Y.   +15 more
europepmc   +1 more source

Comprehensive evidence for the pathogenicity of the <i>BRCA2</i> c.7847C>T (p.Ser2616Phe) variant specific to the Japanese population. [PDF]

J Med Genet
Yamazawa K, Ueki A, Kuga A, Hinoi T, Niitsu H, Minatogawa M, Kawano J, Minami S, Okawa M, Takei J, Ichikawa M, Enokido K, Akimaru N, Torii M, Tsuyuki S, Iguchi C, Inoue T, Nakajima T, Watanabe N, Tanoshima M, Harada-Shoji N, Taruno K, Arai M, Murakami F, Ogawa M, Tamura K, Sugano K, Tanakaya K, Inoue S, Murakami H, Nakashima M, Makabe T, Kosaki K, Matsui A.   +33 more
europepmc   +1 more source

From mutation to treatment: The dual role of BRCA1 and BRCA2 in gynecological malignancy development and management a systematic review. [PDF]

Biochem Biophys Rep
Georgy DM, Sedeek HN, Abaza NE, Eldeeb SEK, Khamis SM, Elgamil MR, Magar RW.   +6 more
europepmc   +1 more source

The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication

Nature Reviews Molecular Cell Biology, 2020
The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA double-strand break (DSB) repair by homologous recombination and protects DNA replication forks from attrition.
Madalena Tarsounas, Patrick Sung, Sung Patrick   +2 more
exaly   +2 more sources

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Brca1 and differentiation

Mutation Research/Reviews in Mutation Research, 2002
Breast cancer is one of the most frequent malignancies affecting women. The human breast cancer gene 1 (BRCA1) gene is mutated in a distinct proportion of hereditary breast and ovarian cancers. Tumourigenesis in individuals with germline BRCA1 mutations requires somatic inactivation of the remaining wild-type allelle. Although, this evidence supports a
Marion, Kubista, Margit, Rosner, Angelina, Miloloza, Katja, Hofer, Andrea-Romana, Prusa, Regina, Kroiss, Erika, Marton, Markus, Hengstschläger   +7 more
openaire   +2 more sources

Perspective on BRCA1

Breast Disease, 1998
In a very real sense, the search for a breast cancer susceptibility gene reflects the rapid evolution of molecular genetics as a field and the power of molecular technology to accelerate the pace of discovery. This search began with the study of blood proteins through biochemical analysis; the number of loci accessible was limited, and very few ...
B, Newman, E T, Liu
openaire   +2 more sources