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New England Journal of Medicine, 2010
The cellular machinery that transports BRCA1 protein to sites of DNA repair is critical to DNA integrity. Two recent studies have identified key components of this machinery.
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The cellular machinery that transports BRCA1 protein to sites of DNA repair is critical to DNA integrity. Two recent studies have identified key components of this machinery.
openaire +2 more sources
Cancer research, 1995
BRCA1, a gene predisposing to breast and ovarian cancer, was mapped to chromosome 17q21 by linkage analysis. Loss of heterozygosity in breast and ovarian tumors from BRCA1-linked patients always involved loss of wild-type alleles from chromosome 17q21, suggesting that BRCA1 acts as a tumor suppressor gene.
L S, Friedman +9 more
openaire +1 more source
BRCA1, a gene predisposing to breast and ovarian cancer, was mapped to chromosome 17q21 by linkage analysis. Loss of heterozygosity in breast and ovarian tumors from BRCA1-linked patients always involved loss of wild-type alleles from chromosome 17q21, suggesting that BRCA1 acts as a tumor suppressor gene.
L S, Friedman +9 more
openaire +1 more source
Family Physicians and Referrals of Low-risk Women for BRCA1/2 Genetic Services
Ca-A Cancer Journal for Clinicians, 2009Mary Desmond Pinkowish, M D Pinkowish
exaly
Survival and prognostic factors in BRCA1-associated breast cancer
Annals of Oncology, 2006Hanne Meijers-Heijboer +2 more
exaly