Results 251 to 260 of about 177,994 (348)

Surgical Outcomes After Risk-Reducing Mastectomy Among BRCA1 and BRCA2 Carriers.

JAMA Netw Open
Wiberg R, Hägglund S, Numan Hellquist B, Rosén A, Idahl A, Mani M, Bajalica-Lagercrantz S, Ehrencrona H, Karlsson P, Loman N, Sund M, Swedish BRCA Study Group.   +11 more
europepmc   +1 more source

Sexual Function, Activity and Distress 24 Months After Surgical Menopause: What Happens After Menopause (WHAM)—A Prospective Controlled Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 6, Page 1188-1199, May 2026.
ABSTRACT Objective To determine the effect of surgical menopause (risk‐reducing salpingo‐oophorectomy, RRSO) on sexual function and the modifying effects of HRT. Design Prospective observational study of women undergoing RRSO and age‐matched comparison group who retained their ovaries. Setting High‐risk clinics and general population.
Martha Hickey, Trevor Tejada‐Berges, Susan M. Domchek, Efrosinia O. Krejany, Alison Brand, Peixuan Li, Sabine Braat, Sheryl Kingsberg   +7 more
wiley   +1 more source

Genomic landscape and clinical impact of BRCA1/2 pathogenic variants in metastatic castration-resistant prostate cancer. [PDF]

NPJ Precis Oncol
Iida K, Urabe F, Matsui Y, Tashiro K, Yoshihara K, Urabe Y, Ishikawa T, Matsuzaki J, Kimura T, Saito Y.   +9 more
europepmc   +1 more source

98 BRCA1 and BRCA2 Mutation in Rwandan Unselected Breast Cancer Patients [PDF]

Alphonsine Mukandekezi
openalex   +1 more source

Copy Number Amplification and c‐Myc Transcriptional Activation‐Mediated RNA‐Binding Protein MEX3A Promotes EGFR‐TKI Resistance in Non–Small‐Cell Lung Cancer

Thoracic Cancer, Volume 17, Issue 9, May 2026.
MEX3A, a pivotal RNA‐binding protein (RBP), which is activated by copy number amplification at the genomic level and regulated by the transcription factor c‐Myc at the transcriptional level, functions as a potential therapeutic target for overcoming TKI resistance in NSCLC. ABSTRACT Objective To investigate the functional role and activation mechanisms
Shi Xiling, Du Lin, Dai Jiali, Zhang Chen, Huang Ruohan, Zhang Chang, Guo Renhua, Li Jun   +7 more
wiley   +1 more source

Carboplatin and taxol resistance develops more rapidly in functional BRCA1 compared to dysfunctional BRCA1 ovarian cancer cells

, 2014
Steven Busschots, Sharon O’Toole, John O’Leary, Britta Stordal   +3 more
openalex   +2 more sources

Aging‐Driven Immunosuppression: The Role of Tregs in the Ovarian Tumor Microenvironment

Aging Cell, Volume 25, Issue 5, May 2026.
In the aged ovarian TME, cancer cells exhibit increased succinate production. Elevated extracellular succinate activates the SUCNR1 receptor on Tregs, promoting their recruitment and contributing to an immunosuppressive environment. This leads to diminished anti‐tumor T cell responses and reduced survival.
Mary P. Udumula, Anjaly KM, Faraz Rashid, Mohammad Nematullah, Harshit Singh, Tanya Bhardwaj, Miriana Hijaz, Shailendra Giri, Eduardo N. Chini, Heather M. Gibson, Ramandeep Rattan   +10 more
wiley   +1 more source

Prevalence of <i>BRCA1</i> Promoter Methylation in Cohorts of Individuals With and Without Cancer Assessed by Circulating Cell-Free DNA. [PDF]

JCO Precis Oncol
Liu ET, Antonio M, Nance T, Menghi F.
europepmc   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, Volume 183, Issue 9, Page 1727-1746, May 2026.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

BARD1 recognizes pre-rRNA for DNA damage repair and rRNA biogenesis. [PDF]

J Biol Chem
Huang H, Wu D, Yu X.
europepmc   +1 more source