Results 241 to 250 of about 143,588 (347)

Impaired glucose tolerance in women with BRCA1 versus BRCA2 pathogenic or likely pathogenic variants: Results from a prospective cohort study. [PDF]

Fam Cancer
Grandi G, Piombino C, Sighinolfi G, Barbieri E, Venturelli M, Melotti C, Lippi Bruni R, Grisendi V, Cuoghi Costantini R, Grippa M, Zattarin E, Tenedini E, Razzaboni E, Brigante G, D'Amico R, Nanni B, Menozzi R, Cortesi L, Dominici M, La Marca A, Toss A.   +20 more
europepmc   +1 more source

PKMYT1 in Cancer: Beyond Cell Cycle Checkpoints to Context‐Dependent Therapeutic Vulnerability

Genes, Chromosomes and Cancer, Volume 65, Issue 7, July 2026.
ABSTRACT PKMYT1 has emerged as a promising therapeutic target distinguished by its tumor‐selective expression and essential role in replication stress management. Unlike WEE1, PKMYT1 is dispensable in normal cell cycles but critical for cancer cells coping with DNA damage, establishing a broad therapeutic window.
Lingxi Li, Binfan He, Mengmeng Hao, Ye Liu, Shunxin Song, Rongzhang He   +5 more
wiley   +1 more source

Clinical predictors of <i>BRCA1/2</i> P/LP variants for high-risk breast cancer patients in China: <i>HBRCA-risk prediction</i>. [PDF]

Front Oncol
Gu W, Xu C, Fu J, Lei H, Khan NU, Lei R, Chen X, Wang XJ, Chen T.   +8 more
europepmc   +1 more source

PVT1 lincRNA signals an androgen‐dependent transcriptional activation program of oncogenes in prostate cancer cells

International Journal of Cancer, Volume 159, Issue 1, Page 144-158, 1 July 2026.
What's New? Unraveling the networks that regulate androgen receptor (AR) function is critical to better understanding prostate cancer development and progression. Of particular interest in this regard is the long non‐coding RNA PVT1, which regulates gene expression in cancer and is upregulated in prostate tumors.
Maria Gabriela Berzoti‐Coelho, Fabio Nunes de Mello, Ana Carolina Tahira, Gabriel Nakanishi Fortes, Agatha Fischer‐Carvalho, Pedro Jardim Poli, Murilo Sena Amaral, Sergio Verjovski‐Almeida   +7 more
wiley   +1 more source

The Performance of <i>In Silico</i> Prediction Tools for Variant Curation in a Panel of Cancer Genes. [PDF]

Hum Mutat
Nelson N, Niaz A, Fairfax K, Bryan TM, Lucas S, Dickinson J.   +5 more
europepmc   +1 more source

Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy

MedComm, Volume 7, Issue 7, July 2026.
Tumor progression is driven by heterogeneity occurring across multiple biological scales. At the molecular level, tumor cells exhibit alterations across distinct omics layers, including genomic mutations, epigenomic reprogramming, transcriptional changes, and proteomic remodeling, collectively shaping tumor cell phenotypes and functional states.
Hanwen Hu, Zhixing Hao, Lili Li, Huiying Liu, Chenghui Yang, Zhen Wang   +5 more
wiley   +1 more source

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment

MedComm, Volume 7, Issue 7, July 2026.
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Qiwen Li, Yating Sun, Shuibin Lin, Quan Yuan   +3 more
wiley   +1 more source

Navigating the healthcare system with a <i>BRCA1/2</i> pathogenic variant: What do patients value? [PDF]

Gynecol Oncol Rep
Karimaghaie T, Webster EM, Levi SR, Blank SV, Walsh C, Rivera LBD, Gilliland J, Vanroboys A, Kirby M, Ahsan MD, Lopez S, Sharaf S, Epstein ES, Ellis A, Frey MK.   +14 more
europepmc   +1 more source

Chemical and Technological Aspects of Magnetic Particles for Cancer Liquid Biopsy Applications

ChemistryOpen, Volume 15, Issue 7, July 2026.
Magnetic bead engineering for liquid biopsy diagnostics reviews advances in magnetic bead design for the selective enrichment of circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and extracellular vesicles (EVs) from complex biofluids.
Beatriz Naranjo‐Martínez, Ana Laura Coria‐Gutiérrez, Sunčica Sukur, Sedef Ozel‐Okcu, Václav Ranc, Francisco J. Terán, Franca Raucci, Marco A. Pierotti, Domenico Scionti, Anna Piperno   +9 more
wiley   +1 more source

Estrogen receptor-positive, BRCA1-deficient breast cancer: BRCA1-epimutated tumors presenting a piece to the puzzle. [PDF]

Breast Cancer Res
Lønning PE, Nikolaienko O, Knappskog S.
europepmc   +1 more source