Results 241 to 250 of about 111,950 (304)

Ghrelin Alleviates Aging‐Related Cognitive Impairment by Regulating Autophagy‐Related Signaling via the SHBG/JNK1/Beclin1 Axis in Microglia

Aging Cell, Volume 25, Issue 10, October 2026.
This study found that aging‐related cognitive impairment is accompanied by hippocampal microglial senescence. Ghrelin suppresses microglial senescence by promoting autophagy through the SHBG/JNK1/Beclin1 axis, thereby alleviating aging‐related cognitive impairment. The graphical abstract was drawn using the Figdraw.
Lixing Zhou, Ying Cheng, Wanyu Zhao, Xuelian Sun, Fengjuan Hu, Meiling Ge, Yan Zhang, Gongchang Zhang, Birong Dong, Xiaolei Liu   +9 more
wiley   +1 more source

Double heterozygous germline pathogenic variants in patients referred to a tertiary cancer genetics clinic in Singapore. [PDF]

Front Oncol
Wong RSJ, Ong PY, Ow SGW, Walsh RJ, Chan G, Lim VPY, Lee SC.   +6 more
europepmc   +1 more source

The ‘Prostate Cancer Screening for People at Genetic Risk of Aggressive Disease’ (PATROL) study

BJU International, Volume 138, Issue 4, Page 600-606, October 2026.
Background Inherited (germline) pathogenic and likely pathogenic variants (gPVs) in key genes associated with increased risk of prostate cancer (PCa) now warrant more attentive PCa screening per National Comprehensive Cancer Network (NCCN) guidelines—e.g., BRCA2, HOXB13, ATM, BRCA1, MSH2, MSH6, CHEK2 and TP53.
Heather H. Cheng, Kara N. Maxwell, Keyan Salari, Matthew R. Cooperberg, Kristin Follmer, Joanne M. Jeter, Grace Jun, Daniel J. Lee, Hiten D. Patel, Edward M. Schaeffer, Alexandra O. Sokolova, Erika M. Wolff, Daniel W. Lin   +12 more
wiley   +1 more source

Differential roles of BRCA1 and BRCA2 in the DNA damage response revealed by isogenic V79 mutant cell lines. [PDF]

Mutagenesis
Chailapakul P, Maeda J, Miura T, Kato TA.   +3 more
europepmc   +1 more source

HRDetect in Tubo-ovarian Carcinoma: Stratification and Therapeutic Implications. [PDF]

Clin Cancer Res
Banda K, Davies HR, Kumar Y, Memari Y, Degasperi A, Radke M, Rodriguez I, Gooley TA, Katz R, Menghi F, Harding T, Lin K, Liu ET, Nik-Zainal S, Swisher EM.   +14 more
europepmc   +1 more source

NTAQ1 Promotes Hepatocellular Carcinoma Growth by Facilitating the Protein Degradation of the Tumor Suppressor PRDM2

Cancer Science, Volume 117, Issue 10, Page 2803-2818, October 2026.
Copy number variation analysis in The Cancer Genome Atlas identified NTAQ1 as a potential driver of HCC progression. NTAQ1 accelerates tumor growth by promoting the degradation of the tumor suppressor protein PRDM2, thereby impairing DNA repair and suppressing apoptosis. These findings indicate that NTAQ1 could be a valuable target for the treatment of
Tomohiko Ikehara, Hajime Otsu, Taro Tobo, Kiyotaka Hosoda, Tadashi Abe, Masahiro Hashimoto, Yusuke Nakano, Katsushi Dairaku, Yuya Ono, Yuki Miyata, Chihiro Matsumoto, Takanari Tatsumi, Satoshi Higuchi, Takashi Ofuchi, Akinori Tsujimoto, Yuki Ando, Qingjiang Hu, Yusuke Yonemura, Akira Shimizu, Takaaki Masuda, Yuji Soejima, Koshi Mimori   +21 more
wiley   +1 more source

The Landscape of BRCA1-Associated Post-Translational Modifications. [PDF]

Cell Biol Int
Waduge NH, Xiao J, Davis GM.
europepmc   +1 more source

Genetic Evolution in BRCA1‐Associated Breast Cancer Reveals Early Driver Mutations Shaping Tumor Features and Prognosis

Cancer Science, Volume 117, Issue 10, Page 2863-2876, October 2026.
Multi‐region sequencing of 57 BRCA1‐associated breast cancers identified TP53 as the dominant initial driver, defining a triple‐negative subgroup with biallelic BRCA1 loss and elevated genomic instability. TP53 truncating mutations were enriched in BRCA1 carriers and linked to reduced HRD, EMT activation, and a trend toward worse survival.
Li Hu, Zhongwu Li, Qiting Wan, Xingyu Liao, Yaxin Zhang, Qian Liu, Xinyun Ding, Hua Meng, Yifan Wu, Jie Sun, Juan Zhang, Lu Yao, Ye Xu, Yuntao Xie   +13 more
wiley   +1 more source

Systemic immune activation in hereditary cancer predisposition syndromes: a cross-sectional study. [PDF]

BMC Med
Kelemen I, Horti-Oravecz K, Bozsik A, Pócza T, Papp J, Likó I, Neuperger P, Balogh F, Kemény Á, Nagy P, Vereczki V, Pósa SP, Pongor LS, Kövesdi D, Butz H, Patócs A, Szebeni GJ, Grolmusz VK.   +17 more
europepmc   +1 more source

Reproductive Challenges in Mutated BRCA Gene Carriers: A Narrative Review. [PDF]

Curr Issues Mol Biol
Vouza M, Papadoliopoulou M, Dimitrakakis K, Zografos G, Michalopoulos NV, Arkadopoulos N.   +5 more
europepmc   +1 more source