Results 261 to 270 of about 143,588 (347)

Optic nerve sheath meningioma exhibits neural niche‐associated transcriptomic features and rare copy number variation‐linked evolution

Brain Pathology, Volume 36, Issue 4, July 2026.
Optic nerve sheath meningiomas are typically NF2‐intact with few copy number alterations and are generally clinically indolent. Rare aggressive recurrences are associated with progressive accumulation of copy number variations, including CDKN2A/B homozygous deletion, 1q gain, and 14q loss.
Daisuke Sato, Satoru Miyawaki, Yu Sakai, Kenta Ohara, Yu Teranishi, Yudai Hirano, Motoyuki Umekawa, Takahiro Tsuchiya, Shotaro Ogawa, So Hirata, Hiroki Hongo, Hideaki Ono, Daisuke Komura, Tetsuo Ushiku, Shumpei Ishikawa, Nobuhito Saito   +15 more
wiley   +1 more source

<i>LincRNA-BC7</i> as a Modulator of Olaparib Sensitivity in Triple-Negative Breast Cancer. [PDF]

Epigenomes
Fadebi OO, Alabi BA, Khanyile R, Dlamini Z, Marima R.   +4 more
europepmc   +1 more source

TONSL Promotes Hepatocellular Carcinoma Progression by Inhibiting Apoptosis Through Homologous Recombination Repair

Cancer Science, Volume 117, Issue 7, Page 1852-1866, July 2026.
In hepatocellular carcinoma, the 8q24.3 locus is frequently amplified and is associated with tumor‐specific overexpression of TONSL. TONSL promotes homologous recombination repair through RAD51, limits γH2AX accumulation and apoptosis, supports tumor growth, and its loss increases sensitivity to poly (ADP‐ribose) polymerase (PARP) inhibition.
Akinori Tsujimoto, Hajime Otsu, Takashi Ofuchi, Tomohiko Ikehara, Kosuke Hirose, Shohei Shibuta, Kazuki Omachi, Yu Takahashi, Yuya Ono, Satoshi Higuchi, Takanari Tatsumi, Kiyotaka Hosoda, Qingjiang Hu, Yusuke Yonemura, Takaaki Masuda, Masayuki Sho, Koshi Mimori   +16 more
wiley   +1 more source

Cost-effectiveness of Population-Based BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2 Mutation Testing in Unselected General Population Women

Journal of the National Cancer Institute, 2018
R. Manchanda, Shreeya Patel, V. S. Gordeev, A. Antoniou, Shantel Smith, Andrew Lee, J. Hopper, R. MacInnis, C. Turnbull, S. Ramus, S. Gayther, P. Pharoah, U. Menon, I. Jacobs, R. Legood   +14 more
semanticscholar   +1 more source

Exploring alternatives to tumor tissue for BRCA1/2 next-generation sequencing testing in high-grade serous ovarian cancer: A 34-case series of malignant ascites. [PDF]

Cancer Cytopathol
Pighi C, Settanni G, Angelini M, Bortesi L, Viassolo V, Ceccaroni M, Bruni F, Gori S, Zannoni GF, Pesci A.   +9 more
europepmc   +1 more source

Genetic Predictors of Progression and Skin Rash in Japanese mCSPC Patients Treated With Apalutamide: CUARTET Study

Cancer Science, Volume 117, Issue 7, Page 1985-1995, July 2026.
In patients with mCSPC treated with apalutamide plus ADT, baseline ctDNA predicted earlier progression to CRPC and worse overall survival. Exploratory genome‐wide analysis identified 12 SNPs associated with apalutamide‐related skin rash. ABSTRACT Despite promising evidence of the efficacy of the androgen deprivation therapy (ADT) plus apalutamide in ...
Masaki Shiota, Taku Naiki, Koji Hatano, Akira Yokomizo, Hiroaki Tsuchiya, Yoko Takahashi, Taku Nakayama, Masaki Yoshida, Hirotsugu Uemura   +8 more
wiley   +1 more source

Impact of Germline <i>BRCA1/2</i> Mutations on Clinical Outcomes in Metastatic Triple-Negative Breast Cancer Patients Treated with Sacituzumab Govitecan-An International CEBCC Study from Poland, the Czech Republic and Slovakia. [PDF]

Oncol Res
Pacholczak-Madej R, Püsküllüoğlu M, Polakiewicz-Gilowska A, Pieniążek M, Kolářová I, Malejčíková M, Rušinová L, Holánek M, Soumarová R, Winsko-Szczęsnowicz K, Żubrowska J, Konieczna A, Młodzińska A, Krejčí D, Danielewicz I, Szymanik-Resko M, Ciszewski T, Lisik-Habib M, Pękala A, Študentová H, Šustr J, Czartoryska-Arłukowicz B, Łacko A, Smok-Kalwat J, Jarząb M, Bielčiková Z, Kubeczko M.   +26 more
europepmc   +1 more source

Skin Cancer Predisposition Genes, Full‐Body Skin Examinations, Familial Disclosure, and Genetic Testing Among High‐Risk Individuals

International Journal of Dermatology, Volume 65, Issue 7, Page 1431-1441, July 2026.
ABSTRACT Background There is a lack of knowledge in full‐body skin examinations (FBSEs) in the context of pathogenic or likely pathogenic variants (PV/LPV) in skin cancer predisposition genes (CPGs). This study assessed the association between carrier status of PV/LPV in skin CPGs and FBSEs and described the patterns of family letter receipt, familial ...
Jincong Q. Freeman, Yu Matsui, Fangyuan Zhao, Olufunmilayo I. Olopade, Dezheng Huo   +4 more
wiley   +1 more source