Results 231 to 240 of about 111,950 (304)

Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments

MedComm, Volume 7, Issue 10, October 2026.
Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma, Xiaoxuan Zhang, Pujun Zhao, Jiaxin Yang, Zhihao Li, Xiaoyang Han, Yixuan Wang, Zhenzhen Cui, Nian Liu, Min Li   +9 more
wiley   +1 more source

<i>BRCA1</i> Gene as a Potential Marker for Lung Cancer Therapy. [PDF]

Int J Mol Sci
Tsyganov MM, Tsydenova IA, Dolgasheva DS, Ibragimova MK.   +3 more
europepmc   +1 more source

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, Volume 270, Issue 2, Page 139-162, October 2026.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

Germline <i>BRCA1</i> pathogenic variants and T cell dysfunction. [PDF]

Immunooncol Technol
Kay J, Harris MA, Lara Gonzalez LE, van Geelen CT, Clarke KA, Virassamy B, Caramia F, Pang JM, O'Malley MMR, Hun ML, Salgado R, Thorne H, Visvader J, Neeson PJ, Darcy PK, Loi S.   +15 more
europepmc   +1 more source

Relating transcriptomics to protein abundance reveals self‐driven versus interactor‐driven proteins

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Statistically modeling the interdependence between transcriptomics and protein abundances remains a persistent challenge in bioinformatics research. Transcriptomic data and proteomic abundances typically display a moderate Pearson's correlation of about 0.5, while in tumor conditions, the correlation may decrease to a much weaker correlation ...
Loulwah Arnaout, Volkhard Helms, Aram Papazian   +2 more
wiley   +1 more source

XYL-1 and Olaparib Synergistically Inhibit the Growth of Pancreatic Cancer by Suppressing the SCD1/BRCA1 Signaling Pathway. [PDF]

Molecules
Yang Y, Huang L, Du Y, Zhu Q, Dai L, Qian B.   +5 more
europepmc   +1 more source

Predictive Value of [−2]proPSA‐Related Indices for Prostate Cancer Detection Years Before Prostate‐Specific Antigen Elevation: Insights From a Five‐Year Longitudinal Screening Cohort

The Prostate, Volume 86, Issue 14, Page 1470-1476, October 2026.
ABSTRACT Background [‐2]proPSA(p2PSA)‐related indices have demonstrated diagnostic value for detecting prostate cancer (PC) in males with modest increases in prostate‐specific antigen levels (PSA) of < 10 ng/mL. However, the “leak point” of p2PSA level in the blood circulation before developing screen‐detectable PC remains uncertain.
Yoshitaka Sekine, Yuji Fujizuka, Syun Nakazawa, Yusuke Tsuji, Akira Ohtsu, Yoshiyuki Miyazawa, Seiji Arai, Masashi Nomura, Hidekazu Koike, Hiroshi Matsui, Kazuto Ito, Kazuhiro Suzuki   +11 more
wiley   +1 more source

Homologous recombination deficiency (HRD) testing of high-grade serous carcinoma using cytological samples. [PDF]

BJC Rep
Demmer I, Schmid MB, Born D, Handschin G, Jochum W.   +4 more
europepmc   +1 more source

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, Volume 40, Issue 10, Page 5973-5987, October 2026.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

Next-generation sequencing-based characterization of BRCA1/2 variants across multiple tumor types in Vietnamese patients. [PDF]

BMC Cancer
Nguyen HT, Vu MD, Nguyen DD, Dinh PN, Hoang VQ, Bui LN, Nguyen DT, Do PH, Tong TO, Nguyen VH, Han TT, Ha ST, Do HD, Ly TT, Nguyen VN.   +14 more
europepmc   +1 more source