Results 211 to 220 of about 177,994 (348)

Germline Pathogenic Variants in Homologous Recombination Pathway Genes Are Frequent in Pancreatobiliary Ampullary Carcinoma. [PDF]

JCO Precis Oncol
Misyura M, Selenica P, Ozcan K, Kemel Y, Basturk O, O'Reilly EM, Reis-Filho JS, Beets-Tan R, Stadler ZK, Weigelt B, Mandelker D.   +10 more
europepmc   +1 more source

Additional file 10 of An immune-centric exploration of BRCA1 and BRCA2 germline mutation related breast and ovarian cancers

, 2020
Ewa Przybytkowski, Thomas P. Davis, Abdelrahman Hosny, Julia Eismann, Ursula A. Matulonis, Gerburg M. Wulf, Sheida Nabavi   +6 more
openalex   +1 more source

Data from Multi-Maintenance Olaparib Therapy in Relapsed, Germline <i>BRCA1/2</i>-Mutant High-Grade Serous Ovarian Cancer (MOLTO): A Phase II Trial

, 2023
Robert D. Morgan, Andrew R. Clamp, Daniel J. White, Marcus Price, George J. Burghel, W. David J. Ryder, Reem D. Mahmood, Alexander D. Murphy, Jurjees Hasan, Claire L. Mitchell, Zena Salih, Chelsey Wheeler, Emma Buckley, Joanna Truelove, Georgia King, Yasmina Ainaoui, Sanjeev S. Bhaskar, Joseph Shaw, D. Gareth Evans, Bedirhan Kilerci, Simon P. Pearce, Gerard Brady, Caroline Dive, James P.B. O’Connor, Andrew J. Wallace, Dominic G. Rothwell, Richard J. Edmondson, Gordon C. Jayson   +27 more
openalex   +1 more source

Single Cell RNA Transcriptomics of Mantle Cell Lymphoma Reveals the Presence of Treatment‐Resistant Subclones at the Time of Diagnosis

American Journal of Hematology, Volume 101, Issue 5, Page 1025-1035, May 2026.
ABSTRACT Mantle cell lymphoma (MCL) is a B‐cell malignancy with a chronically relapsing clinical course and pronounced genetic heterogeneity. To investigate the clonal dynamics underlying early disease relapse, we performed single‐cell RNA sequencing of paired tumor samples collected at diagnosis and at first relapse. Inference of copy number variants (
Dmitry Manakov, Magdalena Klanova, Michal Kolar, Robert Ivanek, Florian Geier, Julien Roux, Tomas Zikmund, Lucie Winkowska, Eva Kriegova, Jirina Manakova, Liliana Tuskova, Silvia Spanikova, Alexandra Scasna, Marek Trneny, Pavel Klener   +14 more
wiley   +1 more source

SERBP1 is required for efficient HR repair and cisplatin chemoresistance in lung adenocarcinoma. [PDF]

Cell Death Discov
Xie Y, Chen Q, Tang N, Zeng Y, Zhao J, Yang Y, Li C, Li J, Zhu J, Huang JA, Liu Z.   +10 more
europepmc   +1 more source

Production of recombinant human BRCA1 encoded proteins in E coli

, 1997
Berna S. Özçelik
openalex   +1 more source

Integrated Molecular Profiling Improves Subtype Classification and Reveals Inherited Susceptibility in Medulloblastoma: Insights From a Real‐World Cohort

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Medulloblastoma (MB) is a heterogeneous pediatric brain tumor characterized by distinct molecular subtypes. Although genomics and transcriptomics have improved subtype classification and informed targeted therapies, the clinical utility of integrated molecular profiling in real‐world settings remains incompletely defined. Methods We
Jiwei Song, Tiantian Han, Siqi Chen, Dongsheng Chen, Ziying Liu   +4 more
wiley   +1 more source

Cryptic redundancy between PAR1b and PAR1a, two members of the PAR1 kinase family, in the survival of PAR1b-knockout mice. [PDF]

Sci Rep
Murata-Kamiya N, Del Valle Lazarte AA, Kikuchi I, Hatakeyama M.   +3 more
europepmc   +1 more source

BRCA1 Interacting Protein COBRA1 Facilitates Adaptation to Castrate-Resistant Growth Conditions [PDF]

, 2018
Huiyoung Yun, Roble Bedolla, Aaron Horning, Rong Li, Huai-Chin Chiang, Tim-H Huang, Robert L. Reddick, Aria F. Olumi, Rita Ghosh, Addanki P. Kumar   +9 more
openalex   +1 more source

Exploring alternatives to tumor tissue for BRCA1/2 next‐generation sequencing testing in high‐grade serous ovarian cancer: A 34‐case series of malignant ascites

Cancer Cytopathology, Volume 134, Issue 5, May 2026.
Abstract Background BRCA1/2 testing is currently recommended at diagnosis for high‐grade serous ovarian carcinoma (HGSOC) because of its impact on patients' survival when treated with poly(adenosine diphosphate ribose) polymerase inhibitors. Standard clinical practice involves analyzing BRCA1/2 genes in formalin‐fixed, paraffin‐embedded (FFPE ...
Chiara Pighi, Giulio Settanni, Marta Angelini, Laura Bortesi, Valeria Viassolo, Marcello Ceccaroni, Francesco Bruni, Stefania Gori, Gian Franco Zannoni, Anna Pesci   +9 more
wiley   +1 more source