Results 191 to 200 of about 177,994 (348)

CEP72 represents a putative Oncogene that negatively regulates the mitotic Function of Brca1 and induces Chromosomal Instability

, 2015
Sina Lüddecke
openalex   +1 more source

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model

Disease Models & Mechanisms
Giusy Tornillo, Lauren Warrington, Howard Kendrick, Adam T. Higgins, Trevor Hay, Sam Beck, Matthew J. Smalley   +6 more
doaj   +1 more source

BRCA1 and BRCA2 pathogenic variants increase the risk of four less common cancer types. [PDF]

ESMO Open
Sasagawa H, Endo M, Iwasaki Y, Usui Y, Koyanagi YN, Innella G, Hadler J, Parsons MT, Numakura K, Kamatani Y, Murakami Y, Matsuo K, Matsuda K, Spurdle AB, Habuchi T, Momozawa Y.   +15 more
europepmc   +1 more source

Metachronous breast cancer in a BRCA1 mutation carrier

, 2023
Karolina Pięta, Izabela Rudy, Maksymilian Kruczała   +2 more
openalex   +2 more sources

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

From mutation to treatment: The dual role of BRCA1 and BRCA2 in gynecological malignancy development and management a systematic review. [PDF]

Biochem Biophys Rep
Georgy DM, Sedeek HN, Abaza NE, Eldeeb SEK, Khamis SM, Elgamil MR, Magar RW.   +6 more
europepmc   +1 more source

Socioeconomic and Demographic Factors in Genetic Testing Utilization Among Advanced Prostate Cancer Patients

The Prostate, Volume 86, Issue 8, Page 941-948, June 2026.
ABSTRACT Purpose Germline genetic testing in patients with advanced prostate cancer (PCa) is underutilized and hypothesized to be impacted by socioeconomic and demographic factors. This single institution, retrospective study assessed the association of income and social vulnerability with genetic referrals and testing.
Alexandra T. Skowron, Karen Childers, Courtney M. Rose, Kyle C. McElyea, Avery K. Supernois, Yousuf Hussain, Mohammed Baseer, Sunita Ghosh, Clara Hwang   +8 more
wiley   +1 more source

Endogenous and environmental factors that induce DNA replication defects and genomic instability in ER-negative heterozygous BRCA1 cells. [PDF]

Sci Rep
Deshpande M, Paniza T, Brown R, Heslin K, Patel N, Madireddy A, Rosenwaks Z, Gerhardt J.   +7 more
europepmc   +1 more source

Inherited predisposition and breast cancer: Modifiers of BRCA1/2‐associated breast cancer risk [PDF]

, 2002
Timothy R. Rebbeck
openalex   +1 more source