Results 181 to 190 of about 111,950 (304)

An Update on Early‐Onset Breast Cancer: Incidence, Risk Factors, Genetic Testing, and Treatment

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Early‐onset breast cancer presents in patients typically under the age of 40, while very early‐onset breast cancer is usually viewed as breast cancer occurring before the age of 35. Early‐onset breast cancer demonstrates specific molecular properties and has worse outcomes compared to its late‐onset breast cancer counterpart.
Leila Jahangiri
wiley   +1 more source

Comprehensive Genomic Profiling Reveals the Mutational Spectrum and Clinical Significance of BRCA1/2 and Other Cancer-Susceptibility Genes in Breast Cancer Patients from Southern Tunisia. [PDF]

Cancers (Basel)
Ammous-Boukhris N, Abdelmaksoud-Dammak R, Ben Kridis W, Ben-Ayed-Guerfali D, Guidara S, Feki A, Kamoun H, Khanfir A, Daoud J, Lizard GH, Gargouri A, Mokdad-Gargouri R.   +11 more
europepmc   +1 more source

New partners for BRCA1 [PDF]

Nature Structural & Molecular Biology, 2007
openaire   +2 more sources

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

GSK3β and Plk1 sequentially phosphorylate ATP-citrate lyase to promote homologous recombination. [PDF]

Sci Adv
Zhou S, Zhou X, Chen Q, Yuan X, Zhu S, Huang J, Wang F, Yan H.   +7 more
europepmc   +1 more source

DNA Methylation and Transcriptomic Profiles of Wilms Tumour Reveal New Deregulated Genes and Epigenetic Processes Relevant for Tumour Stratification and Management

International Journal of Cancer, Volume 159, Issue 11, Page 2736-2754, 1 December 2026.
ABSTRACT Wilms Tumour (WT), the most common kidney cancer in children, presents features of altered kidney development and frequently exhibits molecular alterations at the 11p15.5 imprinted locus, affecting the IGF2 and H19 genes, which contribute to tumour growth and predisposition.
Abu Saadat, Francesco Cecere, Federica Rossetti, Laura Pignata, Emilia D'Angelo, Carlo Giaccari, Gaetano Verde, Paola Quarello, Franca Fagioli, Josep Roma, Manel Esteller, Enrique de Álava, Flavia Cerrato, Andrea Riccio, Angela Sparago   +14 more
wiley   +1 more source

PUM3 is an essential suppressor of replication stress in homologous recombination deficient breast cancer. [PDF]

Nat Commun
Amodeo V, Weekes D, Balan N, Uceda Castro R, D'Uonno N, Konde A, Noel E, Robbez-Masson L, Trendell J, Shlomi M, Walker C, Venkatesh A, Ryan CJ, Moser SC, Jonkers J, Pearl LH, Oliver AW, Krastev DB, Haider S, Grigoriadis A, Pettitt SJ, Lord CJ, Tutt ANJ.   +22 more
europepmc   +1 more source

Clinical Implementation and Oncological Relevance of Molecular Profiling in Brain Metastases Patients—A Multicenter Retrospective Cohort Study

International Journal of Cancer, Volume 159, Issue 10, Page 2562-2574, 15 November 2026.
While current guidelines recommend the analysis of established cancer driver genes in brain metastases, little is known about its real‐life implementation. This multicenter study revealed an upward trend in the profiling rates of surgically treated brain metastases over the past decade, with up to 60% of brain metastases samples undergoing analysis ...
Maria Nikolaeva, Jacopo Bellomo, Meltem Gönel, Vittorio Stumpo, Victor Egon Staartjes, Flavio Vasella, Kevin Akeret, André Sagerer, Anna Maria Zeitlberger, David Wasilewski, Christopher Krämer, Sven König, Julia Onken, Tareq Juratli, Alexander Köpp, Regina Reimann, Marcus Czabanka, Peter Vajkoczy, Ilker Y. Eyüpoglu, Oliver Bozinov, Michael Weller, Emilie Le Rhun, Luca Regli, Carlo Serra, Marian C. Neidert, Stefanos Voglis   +25 more
wiley   +1 more source

Ewing sarcoma fusion oncogene: At the crossroads of transcription and DNA damage response

Molecular & Cellular Oncology, 2018
Aparna Gorthi, Alexander J. R. Bishop
doaj   +1 more source

Risk-Reducing Interventions in Women With Pathogenic Variants in Breast Cancer Susceptibility Genes. [PDF]

JCO Precis Oncol
Russell EM, Nielsen SM, Ellsworth RE, Chwan Ko H, Previs RA, Pineda-Alvarez DE, Esplin ED, Hughes K, Gray SW, Tung NM, Kurian AW.   +10 more
europepmc   +1 more source