Results 161 to 170 of about 111,950 (304)

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model

Disease Models & Mechanisms
Giusy Tornillo, Lauren Warrington, Howard Kendrick, Adam T. Higgins, Trevor Hay, Sam Beck, Matthew J. Smalley   +6 more
doaj   +1 more source

An integrated network toxicology and multi-omics framework prioritizes BRCA1 as a testable candidate in benzo[a]pyrene-associated oral cancer. [PDF]

Front Pharmacol
Ye W, Liu Z, He P.
europepmc   +1 more source

Epigenetic control of cellular plasticity in breast cancer progression

The FEBS Journal, EarlyView.
Cancer cells undergo cell state transitions, termed plasticity, driving cancer progression and dictating therapeutic response. We define breast cancer plasticity into four interconnected processes: (1) breast cancer stem cell fates, (2) epithelial‐to‐mesenchymal transition, (3) maintenance of luminal identity, and (4) acquisition of therapeutic ...
Ellie J. Massey, Elizabeth Podleszanski, William J. Muller   +2 more
wiley   +1 more source

Expanding the therapeutic scope of PARP inhibitors in breast cancer: current indications and future directions. [PDF]

J Clin Invest
Walmsley CS, Rodriguez A, Konstantinopoulos PA, Shapiro GI, Tolaney SM, Garber JE, Lynce F.   +6 more
europepmc   +1 more source

Additional sectioning and AI‐assisted diagnosis reveal underdiagnosis of serous (pre)malignancies in fallopian tube specimen from BRCA1/2 carriers

Histopathology, EarlyView.
This paper shows that deeper sections reveal additional STICs and HGSCs in risk‐reducing salpingo‐oophorectomy specimens of patients who did not have a STIC or HGSC diagnosis but did develop peritoneal HGSC 10 years after surgery. This adds to the premise that HGSC originates in the fallopian tube.
Anouk B Bouwmeester, Tamar A Gootzen, Marielle Nobbenhuis, Vilius Rudaitis, Caroline B van den Berg, Heleen J van Beekhuizen, Luthy SM Alcalá, Dineke PM Smedts, Nicole CM Visser, Viola Verhoef, Trudy GN Jonges, Ronald P Zweemer, Alicia Leon‐Catillo, Carlijn Lems, Joanne A de Hullu, Jeroen AWM van der Laak, Miranda P Steenbeek, Michiel Simons   +17 more
wiley   +1 more source

The dual immune landscape of homologous recombination-deficient tumors: mechanisms and therapeutic implications. [PDF]

Cancer Metastasis Rev
Yang Y, Yin Y, Rong S, Qian Y, Li D, Zhang Y, Wang X.   +6 more
europepmc   +1 more source

ATXR5 and ATXR6 restrict meiotic crossover formation within heterochromatin in Arabidopsis

Journal of Integrative Plant Biology, EarlyView.
The Arabidopsis H3K27 mono‐methyltransferases ATXR5 and ATXR6 repress crossovers within meiotic heterochromatin, are required for heterochromatin condensation and H3K27me1 establishment, and specifically influence the maintenance of DNA methylation in meiocytes.
Jun Zhang, Yue Yu, Han Wang, Meiling Li, Dingning Li, Chenjiang You, Yingxiang Wang, Cong Wang   +7 more
wiley   +1 more source

Liquid biopsy: a new window on the BRCA genes. [PDF]

ESMO Open
Incorvaia L, Gristina V, Pepe F, Bazan Russo TD, Santoni M, Mujacic C, Curigliano G, Malapelle U, Capoluongo ED, Russo A.   +9 more
europepmc   +1 more source

Optimizing Hereditary Cancer Risk Assessment and Genetic Testing Workflow in Interprofessional Women's Health Practice: A Multicenter Survey of Advanced Practice Providers

Journal of Midwifery &Women's Health, EarlyView.
Introduction Advanced practice providers (APPs), including certified nurse‐midwives (CNMs)/certified midwives and nurse practitioners, are well positioned to meet the growing demand for women's health care services. In interprofessional obstetric and gynecologic settings, APPs’ scope of practice includes performing hereditary cancer risk assessments ...
Elaine Mielcarski, Dana Karanik, Heather Bagley, Edith Smith, Amanda Steele, Logan Schneider, Lauren Lenz, Royce T. Adkins   +7 more
wiley   +1 more source