BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Surgical menopause, the removal of both ovaries prior to natural menopause, may impact short‐and long‐term physical and emotional health. An increasingly common cause of surgical menopause is risk‐reducing salpingo‐oophorectomy (RRSO) in those at high inherited risk of ovarian cancer.
Sarah A. L. Price +12 more
wiley +1 more source
RISK FACTORS OF OVARIAN CANCER AND POSSIBLE PREVENTIVE STRATEGIES
Фундаментальная и клиническая медицина, 2018 Here we review the current data on prevention, diagnosis, and treatment of ovarian cancer, one of the most prevalent genitourinary cancers characterized by high mortality and case fatality rates due to the lack of efficient screening and treatment ...
OLGA B. Karelina +2 more
doaj
Translational Oncogenomics and Human Cancer Interactome Networks [PDF]
, 2011 An overview of translational, human oncogenomics, transcriptomics and cancer interactomic networks is presented together with basic concepts and potential, new applications to Oncology and Integrative Cancer Biology.
I. C. Baianu
core +1 more source
Sperm quality and fertility are compromised in brca1 mutant male mice [PDF]
, 2015 Robert Stobezki +4 more
openalex +1 more source
Risk of Cancer With Hormone Replacement Therapy: A Narrative Review
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Hormone replacement therapy (HRT) remains the cornerstone of menopausal symptom management, effectively alleviating vasomotor symptoms and genitourinary syndrome, whilst mitigating long‐term risks such as osteoporosis. However, despite an increasing body of evidence on the relative safety of HRT, earlier studies that demonstrated an increased ...
Gabriella Yongue +3 more
wiley +1 more source
Genetics and Molecular BiologyThe polymorphic variants of BRCA1, which lead to amino acid substitutions, have a known pathogenic role in breast cancer. The present study investigated in North Indian breast cancer patients the association of risk with four reported pathogenic variants
Akeen Kour +6 more
doaj +1 more source
Novel associations between BRCA1 variants c.181 t>g (rs28897672) and ovarian cancer risk in Saudi females [PDF]
Journal of Medical Biochemistry, 2019 Background: Mutations in BRCA1 gene have been implicated in ovarian cancers, and BRCA testing may be conducted in high-risk women. This study was designed to determine the frequency of three single nucleotide polymorphisms (SNPs) variants in BRCA1 gene ...
Alyahr Nora +11 more
doaj
Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in Cypriot population. [PDF]
, 2010 Inability to correctly repair DNA damage is known to play a role in the development of breast cancer. Single nucleotide polymorphisms (SNPs) of DNA repair genes have been identified, which modify the DNA repair capacity, which in turn may affect the risk
Bashiardes, E +9 more
core
Germline and Somatic BRCA1/2 Mutations in 172 Chinese Women With Epithelial Ovarian Cancer
, 2020 Yan You +7 more
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Supplementary Table S5 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer [PDF]
, 2023 Ee Ming Wong +8 more
openalex +1 more source