Results 131 to 140 of about 111,950 (304)
Evaluation of healthcare management issues in the provision of clinical services for familial breast/ovarian cancer [PDF]
, 2009 Electronic version does not contain associated previously published materialDespite there being pragmatic national guidelines for assigning risk to women with a family history of breast cancer, the evidence base is still sparse.
de Azevedo Moreira Reis, Marta
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Genetics and Molecular BiologyThe polymorphic variants of BRCA1, which lead to amino acid substitutions, have a known pathogenic role in breast cancer. The present study investigated in North Indian breast cancer patients the association of risk with four reported pathogenic variants
Akeen Kour +6 more
doaj +1 more source
Novel associations between BRCA1 variants c.181 t>g (rs28897672) and ovarian cancer risk in Saudi females [PDF]
Journal of Medical Biochemistry, 2019 Background: Mutations in BRCA1 gene have been implicated in ovarian cancers, and BRCA testing may be conducted in high-risk women. This study was designed to determine the frequency of three single nucleotide polymorphisms (SNPs) variants in BRCA1 gene ...
Alyahr Nora +11 more
doaj
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objective To investigate the role of TNF receptor‐associated factor 6 (TRAF6), interleukin 1 receptor‐associated kinase 1 (IRAK1), and miR‐146a‐5p expression levels in the pathogenesis of recurrent tonsillitis. Study Design Case‐control study. Setting The study was conducted at the Department of Otorhinolaryngology, Muğla Training and Research
Ömer Faruk Güzel +3 more
wiley +1 more source
GenProb‐PCSM: A Simplified Weighted Germline Score for Prostate Cancer‐Specific Mortality
The Prostate, EarlyView.ABSTRACT Background We previously developed a tier‐based germline classification using the National Comprehensive Cancer Network (NCCN)‐recommended DNA damage repair (DDR) genes and KLK3 I179T to predict prostate cancer (PCa)‐specific mortality (PCSM).
Jun Wei +14 more
wiley +1 more source
Age of natural menopause onset in BRCA1/2 carriers – systematic review and meta-analysis
Menopause Review, 2021 Łukasz Kępczyński +6 more
doaj +1 more source
, 2018 Accurately identifying patients with high-grade serous ovarian carcinoma (HGSOC) who respond to poly(ADP-ribose) polymerase inhibitor (PARPi) therapy is of great clinical importance.
Ho, GY +14 more
core +1 more source
Impact of sleep insufficiency and recovery on cancer development
Sleep Research, EarlyView.Abstract Sleep plays a critical role in overall health, and modern lifestyles, such as shift work and late‐night activities, can significantly impact sleep condition. Insufficient sleep has been associated with various adverse health outcomes, including an increased risk of tumor development.
Xiaxi Li, Chuanyuan Li, Yi Zhang
wiley +1 more source
Differentiating high‐ and low‐grade serous ovarian carcinoma using radiomics: a pilot study
Ultrasound in Obstetrics &Gynecology, EarlyView.ABSTRACT Objective To identify ultrasound‐based radiomics features capable of distinguishing between high‐grade serous ovarian carcinomas (HGSC) and invasive low‐grade serous ovarian carcinomas (LGSC), and to develop machine‐learning models that include radiomics features to discriminate between the two.
F. Ciccarone +17 more
wiley +1 more source
Rapid screening by Surveyor Nuclease-based mutation detection for BRCA1 and BRCA2 genes
, 2009 Twenty-three percent of first diagnosed breast cancer patients resulted to be candidate for BRCA genetic test and, among these, BRCA1 and BRCA2 mutations occur in almost 20% patients. BRCA testing is complicated by the large gene region and the extent of
B. Pilato +8 more
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