Results 151 to 160 of about 143,588 (347)

BRCA1(185delAG) tumors may acquire therapy resistance through expression of RING-less BRCA1 [PDF]

, 2016
Heterozygous germline mutations in breast cancer 1 (BRCA1) strongly predispose women to breast cancer. BRCA1 plays an important role in DNA double-strand break (DSB) repair via homologous recombination (HR), which is important for tumor suppression ...
Taniguchi, T. (Toshiyasu), Serra, Violeta, Rottenberg, Sven, Brandsma, Inger, Dekkers, Dick H W, Dafni Chondronasiou, Burg, E, Klarenbeek, Sjoerd, Cruz, C. (Cristina), van Deemter, L, Elkon, R. (Ran), Dekkers, D.H. (Dick), Chondronasiou, D, Wientjens, Ellen, Jonkers, J, Cruz, C, Eline van der Burg, Fabricio Loayza-Puch, Castroviejo-Bermejo, Marta, Pieterse, M, Boon, U. (Ute), Jonkers, Jos, Ute Boon, Christiaan Klijn, Klarenbeek, S, Balmaña, Judith, Cristina Cruz, Drost, R, Rinske Drost, Castroviejo-Bermejo, M. (Marta), van Deemter, Liesbeth, Serra, V, Elkon, Ran, Bouwman, P, Serra, V. (Violeta), Toshiyasu Taniguchi, Inger Brandsma, Agami, R. (Reuven), Boon, Ute, Jeroen A.A. Demmers, Pieterse, Mark, Peter Bouwman, Rottenberg, S. (Sven), Balmana, J. (Judith), Burg, E. (Eline) van der, Ingrid van der Heijden, Bouwman, Peter, Marieke van de Ven, Dekkers, Dick, van de Ven, Marieke, Judith Balmaña, Wientjens, E. (Ellen), Jonkers, J. (Jos), van der Gulden, H, Schut, E, Ven, H.W.M. (Marieke) van de, Marta Castroviejo-Bermejo, van Gent, Dik C, Dhillon, K.K. (Kiranjit K.), Kiranjit K. Dhillon, Klijn, Christiaan, Hanneke van der Gulden, Rottenberg, S, Loayza-Puch, F. (Fabricio), Balmana, J, Ellen Wientjens, van Gent, Dik; id_orcid, Taniguchi, T, Mark Pieterse, Klijn, C. (Christiaan), Chondronasiou, Dafni, Dick H.W. Dekkers, Van Der Heijden, I. (Ingrid), Cruz, Cristina, van Gent, Dik, Van Deemter, L. (Liesbeth), Dhillon, KK, Elkon, R, Van Der Gulden, H. (Hanneke), Loayza-Puch, F, Schut, E. (Eva), Klarenbeek, S. (Sjoerd), van de Ven, M (Marieke), Drost, Rinske, van der Heijden, Ingrid, Wientjens, E, Boon, U, van der Burg, Eline, Agami, R, Sjoerd Klarenbeek, Ran Elkon, van der Heijden, I, Loayza-Puch, Fabricio, Klijn, C, Taniguchi, Toshiyasu, Castroviejo-Bermejo, M, Demmers, Jeroen, Reuven Agami, Violeta Serra, Brandsma, I. (Inger), Jos Jonkers, Dhillon, Kiranjit K, van der Gulden, Hanneke, Schut, Eva, Agami, Reuven, Bouwman, P. (Peter), Demmers, Jeroen A A, Gent, D.C. (Dik) van, Dik C. van Gent, Pieterse, M. (Mark), Sven Rottenberg, Liesbeth van Deemter, Eva Schut, Drost, R. (Rinske), Demmers, J.A.A. (Jeroen), Chondronasiou, D. (Dafni)   +115 more
core   +1 more source

Prevalence of Helicobacter pylori Exposure and Risk Factors Among BRCA1 and BRCA2 Carriers

International Journal of Cancer, EarlyView.
BRCA1 and BRCA2 pathogenic germline variant (PGV) carriers may be at increased risk of gastric cancer (GC), especially in the case of prior or active Helicobacter pylori (Hp) infection. The extent to which Hp influences BRCA1 and BRCA2‐associated GC remains uncertain. Here, the authors evaluated plasma samples from a U.S. cohort of BRCA1, BRCA2, PALB2,
Kole H. Buckley, Yuhan Zhu, Kevin Dinh, Ryan Hausler, Rohan Gala, Sophia R. Spiegel, Rosella Delgado, Daniel G. Clay, Gregory M. Kelly, Jamie Brower, Susan M. Domchek, Kara N. Maxwell, Bryson W. Katona   +12 more
wiley   +1 more source

Association of Risk-Reducing Surgery in BRCA1 or BRCA2 Mutation Carriers with Cancer Risk and Mortality

Journal of the American Medical Association (JAMA), 2010
Context Risk-reducing mastectomy (RRM) and salpingo-oophorectomy (RRSO) are widely used by carriers of BRCA1 or BRCA2 mutations to reduce their risks of breast and ovarian cancer. Objectives To estimate risk and mortality reduction stratified by mutation
S. Domchek, T. Friebel, C. Singer, D. Evans, H. Lynch, C. Isaacs, J. Garber, S. Neuhausen, E. Matloff, R. Eeles, G. Pichert, Laura Van t'veer, N. Tung, J. Weitzel, F. Couch, W. Rubinstein, P. Ganz, M. Daly, O. Olopade, G. Tomlinson, J. Schildkraut, J. Blum, T. Rebbeck   +22 more
semanticscholar   +1 more source

Cancer Incidence in BRCA1 Mutation Carriers

, 2002
Background: Germline BRCA1 mutations confer a substantial lifetime risk of breast and ovarian cancer, but whether cancer at other sites is increased is less clear.
Thompson, D., Breast Cancer Linkage Consortium, ., Easton, D. F.   +2 more
core   +1 more source

Pancreatic Cancer Early Detection Biomarkers for High‐Risk Individuals: Insights From the PRECEDE Consortium

International Journal of Cancer, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to its asymptomatic progression, late‐stage diagnosis, and treatment resistance. Efforts in early detection have centered on identifying imaging features and liquid biopsy biomarkers capable of detecting PDAC and its high‐grade precursors before clinical symptoms ...
Christine Worthington, Maria Raitses‐Gurevich, Giulio Innamorati, Phil A. Hart, Thomas M. Wilkie, Noam Tau, Dana Brin, Doron Yablecovitch, Ido Laish, Dove Keith, Kurt Giles, Jennifer B. Permuth, Diane M. Simeone, George Zogopoulos, Randall E. Brand, John J. Graff, Julie Earl, On behalf of the PRECEDE Consortium, Nikhil Agarwal, Laufey Amundadottir, Michelle Anderson, Ajay Bansal, Todd Bauer, Georg Beyer, Yan Bi, Erkut Borazanci, Randy Brand, Teri Brentnall, Carol Burke, Darren Carpizo, Saurabh Chawla, Daniel Chung, Sourat Darabi, Michael Demeure, Timothy Donahue, Julie Earl, Whitney Espinel, James Farrell, Vigdís Fjóla Stefánsdóttir, Jared Forrester, Eitan Friedman, Paul Franklin, Srinivas Gaddam, Ana García García de Paredes, Steven Gallinger, Talia Golan, Ora Gordon, Robert Grant, William Greenhalf, Eli Marie Grindedal, Aaron Grossberg, Brenda Hafers, Heather Hannon, Sigurdís Haraldsdóttir, Stefán Haraldsson, Peter Hegyi, Melissa Hogg, Amy de Haar‐Holleman, Susan Hong, Greg Idos, Edward Kim, Fay Kastrinos, Bryson Katona, Vivek Kaul, Derk Klatte, Kelsey Klute, Kimberly Ku, Sonia Kupfer, Rich Kwon, Rosario Ligresti, James James Lin, Wei‐Chih (David) Liao, Aimee Lucas, Nipun Merchant, Andrew Metz, Whitney Maxwell, James McLoughlin, Sodech Miclette, Xavier Molero, Leticia Moreira, Takuji Okusaka Chigusa Morizane, Joanne Ngeow, Salvatore Paiella, Jennifer Permuth, Maricel Purcell, Joshua Raff, Vineet Rolston, Intan Schrader, Rosie Sears, Yan‐Shen Shan, Diane Simeone, Jens Siveke, Brett Sheppard, Tyler Stevens, Elena Stoffel, Dan Sussman, Margaret Tempero, Jose Trevino, Jennifer Valerin, Eva Vaquero, Ray Wadlow, Garrett Ward, David Weinberg, Ronald Wolf, Dana Zakalik, George Zogopoulos   +105 more
wiley   +1 more source

Role of the Nrf2/ARE Pathway in the mtDNA Reparation

Frontiers in Bioscience-Landmark
Mitochondrial DNA (mtDNA) is located in the mitochondrial matrix, in close proximity to major sources of reactive oxygen species (ROS) in the cell. This makes mtDNA one of the most susceptible components to damage in the cell.
Artem P. Gureev, Ekaterina V. Chernyshova, Ekaterina P. Krutskikh, Irina S. Sadovnikova, Elena E. Tekutskaya, Anna A. Dorohova   +5 more
doaj   +1 more source

Relationship between DNA damage response and telomere maintenance [PDF]

, 2012
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Telomeres are regions of repetitive DNA bound with a set of specialized proteins required to protect chromosomes from fusing with each other and from ...
Ojani, Maryam
core  

Clinical Implementation and Oncological Relevance of Molecular Profiling in Brain Metastases Patients—A Multicenter Retrospective Cohort Study

International Journal of Cancer, EarlyView.
While current guidelines recommend the analysis of established cancer driver genes in brain metastases, little is known about its real‐life implementation. This multicenter study revealed an upward trend in the profiling rates of surgically treated brain metastases over the past decade, with up to 60% of brain metastases samples undergoing analysis ...
Maria Nikolaeva, Jacopo Bellomo, Meltem Gönel, Vittorio Stumpo, Victor Egon Staartjes, Flavio Vasella, Kevin Akeret, André Sagerer, Anna Maria Zeitlberger, David Wasilewski, Christopher Krämer, Sven König, Julia Onken, Tareq Juratli, Alexander Köpp, Regina Reimann, Marcus Czabanka, Peter Vajkoczy, Ilker Y. Eyüpoglu, Oliver Bozinov, Michael Weller, Emilie Le Rhun, Luca Regli, Carlo Serra, Marian C. Neidert, Stefanos Voglis   +25 more
wiley   +1 more source

Mechanisms of BRCA1–BARD1 nucleosome recognition and ubiquitylation

Nature, 2021
Q. Hu, M. Botuyan, Debiao Zhao, G. Cui, E. Mer, G. Mer   +5 more
semanticscholar   +1 more source

Nanopore direct RNA sequencing and the epitranscriptome: Advances in mapping native RNA landscapes

iMeta, EarlyView.
Nanopore direct RNA sequencing advances transcriptomics by capturing full‐length transcripts and multiple RNA modifications; this review details its principles, workflows, tools, applications, challenges, and future research potential. Abstract Nanopore direct RNA sequencing (DRS) has transformed transcriptomics by enabling single‐molecule, long‐read ...
Tianyuan Zhang, Jia Li, Chao Tang, You Wu, Hao Wu, Xi‐Tong Zhu, Ziyang Luo, Hang Qin, Lishan Ding, Yu Zeng, Shiou Yih Lee, Xiaotao Shen, Shiwen Gao, Zhaoyang Tian, Qian Tang, Mian Li, Muhammad Tahir Ul Qamar, Yang Dong, Komivi Dossa, Yaxuan Zhang, Hu Chen, Sanqi An, Xiang Yu, Lu Chen, Dingjie Wang, Shengli Li, Ling‐Ling Chen, Yanqiang Li   +27 more
wiley   +1 more source