Results 171 to 180 of about 177,994 (348)

Figure S2 from A Population of Heterogeneous Breast Cancer Patient-Derived Xenografts Demonstrate Broad Activity of PARP Inhibitor in BRCA1/2 Wild-Type Tumors

, 2023
Kurt W. Evans, Erkan Yuca, Argun Akçakanat, Stephen Scott, Natalia Paez Arango, Xiaofeng Zheng, Ken Chen, Coya Tapia, Emily Tarco, Agda Karina Eterovic, Dalliah M. Black, Jennifer K. Litton, Timothy A. Yap, Debu Tripathy, Gordon B. Mills, Funda Meric‐Bernstam   +15 more
openalex   +1 more source

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, EarlyView.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source

Supplementary Tables 1-2 from The Relative Contribution of Point Mutations and Genomic Rearrangements in <i>BRCA1</i> and <i>BRCA2</i> in High-Risk Breast Cancer Families

, 2023
Maurizia Dalla Palma, Susan M. Domchek, Jill E. Stopfer, Julie Erlichman, Jill D. Siegfried, Jessica Tigges-Cardwell, Bernard A. Mason, Timothy R. Rebbeck, Katherine L. Nathanson   +8 more
openalex   +1 more source

Targeting Egfr‐Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration

Cell Proliferation, EarlyView.
AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu, Shifei Song, Ruilin Wang, Ni An, Jinmei Diao, Yuguo Chen, Juan Liu, Guoyue Lv   +7 more
wiley   +1 more source

Supplementary Methods from Impact of Intertumoral Heterogeneity on Predicting Chemotherapy Response of BRCA1-Deficient Mammary Tumors

, 2023
Sven Rottenberg, Marieke A. Vollebergh, Bas de Hoon, Jorma de Ronde, Philip C. Schouten, Ariena Kersbergen, Serge A.L. Zander, Marina Pajic, Janneke E. Jaspers, Martijn Jonkers, Martin Lodén, Wendy Sol, Eline van der Burg, Jelle Wesseling, Jean‐Pierre Gillet, Michael M. Gottesman, Joost Gribnau, Lodewyk F.A. Wessels, Sabine C. Linn, Jos Jonkers, Piet Borst   +20 more
openalex   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

The FEBS Journal, EarlyView.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak, In‐Ja L. Byeon, Ryan Ponticelli, Mary E. Lucas, Lariah Thompson, Christopher DeHaven, Gary Thomas, Angela M. Gronenborn   +7 more
wiley   +1 more source

Supplementary Table 2 from Prolonged Postovulatory Proinflammatory Signaling in the Fallopian Tube Epithelium May Be Mediated through a BRCA1/DAB2 Axis

, 2023
Alicia Tone, Carl Virtanen, Patricia Shaw, Theodore J. Brown   +3 more
openalex   +1 more source

Skin Cancer Predisposition Genes, Full‐Body Skin Examinations, Familial Disclosure, and Genetic Testing Among High‐Risk Individuals

International Journal of Dermatology, EarlyView.
ABSTRACT Background There is a lack of knowledge in full‐body skin examinations (FBSEs) in the context of pathogenic or likely pathogenic variants (PV/LPV) in skin cancer predisposition genes (CPGs). This study assessed the association between carrier status of PV/LPV in skin CPGs and FBSEs and described the patterns of family letter receipt, familial ...
Jincong Q. Freeman, Yu Matsui, Fangyuan Zhao, Olufunmilayo I. Olopade, Dezheng Huo   +4 more
wiley   +1 more source

Mitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function [PDF]

, 2019
Byrum, Andrea K, Carvajal‑Maldonado, Denisse, Gygi, Steven P, Harper, J. W, Majid, Mona C, Mosammaparast, Nima, Mudge, Miranda C, Patel, Romil, Shi, Yang, Sowa, Mathew E, Valle‑Garcia, David, Vindigni, Alessandro   +11 more
core   +2 more sources