Results 121 to 130 of about 143,588 (347)
Topology‐Aware Deep Learning on Higher‐Order Structures for Drug Response Prediction
Advanced Science, EarlyView.We present TopDr, a topology‐aware deep learning framework that encodes both drugs and cell lines as multiscale simplicial complexes, capturing interactions at the 0‐, 1‐, and 2‐simplex levels. By jointly integrating local higher‐order neighborhoods and global topological structures, TopDr generates enriched representations for sensitivity prediction ...
Cong Shen +3 more
wiley +1 more source
Overview of History and Progress in BRCA1 Research: The First BRCA1 Decade [PDF]
Cancer Biology & Therapy, 2004 The BRCA1 protein presents a paradox to the scientists investigating its link to cancer. BRCA1 provides a function essential to all cell types, but its mutation is only associated with a subset of cancers including breast and ovarian cancers. The priorities of BRCA1 research are the identification of the function of BRCA1, which is required in all ...
openaire +2 more sources
The World Journal of Men's HealthProstate cancer (PC) treatment has reached a milestone with the introduction of poly(ADP-ribose) polymerase (PARP) inhibitors. PARP inhibitors (PARPi) induce breaks in single-stranded and/or double-stranded DNA, resulting in synthetic lethality in ...
Whi-An Kwon
doaj +1 more source
, 2007 Rare inactivating mutations in BRCA1, BRCA2, ATM, TP53 and CHEK2 confer relative risks for breast cancer between about 2 and more than 10, but more common variants in these genes are generally considered of little or no clinical significance.
dos Santos Silva, Isabel +31 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu +3 more
wiley +1 more source
BRCA1 haploinsufficiency is masked by RNF168-mediated chromatin ubiquitylation
Molecules and Cells, 2019 SUMMARY BRCA1 functions at two distinct steps during homologous recombination (HR). Initially, it promotes DNA end resection, and subsequently recruits the PALB2 and BRCA2 mediator complex, which stabilizes RAD51-DNA nucleoprotein filaments.
D. Zong +16 more
semanticscholar +1 more source
, 2014 Although evidence suggests an importance of genetic factors in the development of breast cancer in Taiwanese (ethnic Chinese) women, including a high incidence of early-onset and secondary contralateral breast cancer, a major breast cancer predisposition
Kuo, Wen-Hong;Lin, Po-Han;Huang, Ai-Chu;Chien, Yin-Hsiu;Liu, Tsang-Pai;Lu, Yen-Shen;Bai, Li-Yuan;Sargeant, Aaron M.;Lin, Ching-Hung;Cheng, Ann-Lii;Hsieh, Fon-Jou;Hwu, Wuh-Liang;Chang, King-Jen +1 more
core +1 more source
Promotion of RAD51-mediated homologous DNA pairing by BRCA1-BARD1
Nature, 2017 The tumour suppressor complex BRCA1–BARD1 functions in the repair of DNA double-stranded breaks by homologous recombination. During this process, BRCA1–BARD1 facilitates the nucleolytic resection of DNA ends to generate a single-stranded template for the
Weixing Zhao +19 more
semanticscholar +1 more source
Oocyte–cumulus cell interaction: a key factor in early embryo development
Biological Reviews, EarlyView.ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido +2 more
wiley +1 more source