Results 101 to 110 of about 143,588 (347)

Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway

Cells, 2020
Research on repurposing the old alcohol-aversion drug disulfiram (DSF) for cancer treatment has identified inhibition of NPL4, an adaptor of the p97/VCP segregase essential for turnover of proteins involved in multiple pathways, as an unsuspected cancer ...
Dusana Majera, Zdenek Skrott, Katarina Chroma, Joanna Maria Merchut-Maya, Martin Mistrik, Jiri Bartek   +5 more
doaj   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer

OncoTarget, 2016
Immune checkpoint inhibitors (e.g., anti-PD-1 and anti-PD-L1 antibodies) have demonstrated remarkable efficacy against hypermutated cancers such as melanomas and lung carcinomas.
K. Strickland, B. Howitt, S. Shukla, S. Rodig, Lauren L. Ritterhouse, Joyce F. Liu, J. Garber, Dipanjan Chowdhury, Catherine J. Wu, A. D’Andrea, U. Matulonis, P. Konstantinopoulos   +11 more
semanticscholar   +1 more source

Role of Single Nucleotide Polymorphisms in BRCA1 and BRCA2 Genes Relative to Previous Studies in Pakistan in the Prognosis of Breast Cancer [PDF]

Journal of Liaquat National Hospital
Breast cancer is a complex disease characterized by a myriad of genetic alterations. Single nucleotide polymorphisms are particularly relevant due to small allelic variations.
Saba Munir, Yasir Nawaz, Fouzia Tanvir, Maria Akram, Muhammad Luqman, Javaria Zafar, Muhammad Zaman   +6 more
doaj   +1 more source

Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase

Cells, 2020
DNA damage and base excision repair (BER) are actively involved in the modulation of DNA methylation and demethylation. However, the underlying molecular mechanisms remain unclear.
Zhongliang Jiang, Yanhao Lai, Jill M. Beaver, Pawlos S. Tsegay, Ming-Lang Zhao, Julie K. Horton, Marco Zamora, Hayley L. Rein, Frank Miralles, Mohammad Shaver, Joshua D. Hutcheson, Irina Agoulnik, Samuel H. Wilson, Yuan Liu   +13 more
doaj   +1 more source

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

Bayesian assessment of the prevalence of BRCA-associated breast cancer in Moscow

Alʹmanah Kliničeskoj Mediciny, 2020
Rationale: For many years, breast cancer has been leading in the cancer structure in women, accounting for 21% from the total number of newly diagnosed cases of malignancies in Russia. The literature on the prevalence of the BRCA-associated breast cancer
A. V. Viskovatykh
doaj   +1 more source

A family history of breast cancer will not predict female early onset breast cancer in a population-based setting [PDF]

, 2008
: BACKGROUND: An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening.
de Bock, Geertruida H.; id_orcid, Seynaeve, C., Krol-Warmerdam Elly MM, Blom Jannet, de Bock, G.H., Cornelisse, C.J., Blom, Jannet, de Bock, GH, Brekelmans, C.T., Asperen, C.J. (Christi) van, Klijn, J.G., Jacobi, Catharina E., Houwelingen, J.C. van, van Asperen Christi J, Krol-Warmerdam, Elly M. M., Devilee, P, Brekelmans, C.T. (Cecile), Brekelmans Cecile TM, Klijn, Jan G. M., de Bock Geertruida H, Krol-Warmerdam, E.M., Krol-Warmerdam, EMM, van Asperen, C.J., Blom, J. (Jannet), Cornelisse Cees J, Jacobi, C.E., Tollenaar Rob AEM, Cornelisse, Cees J., Krol-Warmerdam, E.M.M. (Elly), Tollenaar, R.A., Seynaeve, C.M. (Caroline), Jacobi, CE, Tollenaar, R.A.E.M. (Rob), de Bock, Geertruida H., Blom, J., van Houwelingen, JC, Tollenaar, Rob A. E. M., van Asperen, Christi J., Brekelmans, CTM (Cecile), Bock, G.H. (Geertruida) de, van Asperen, CJ, Klijn Jan GM, van Houwelingen Johannes C, Devilee, Peter, Seynaeve Caroline, Brekelmans, Cecile T. M., Seynaeve, Caroline, Devilee Peter, Klijn, J.G.M. (Jan), Jacobi Catharina E, van Houwelingen, J.C., Klijn, Jan, Jacobi, C.E. (Catharina), Devilee, P. (Peter), Tollenaar, RAEM, Devilee, P., Cornelisse, C.J. (Cees), van Houwelingen, Johannes C., Blom, J, Cornelisse, CJ   +59 more
core   +1 more source

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

BRCA1 at a branch point [PDF]

Proceedings of the National Academy of Sciences, 2001
The breast- and ovarian-specific tumor suppressor protein, BRCA1, has been implicated in regulating the nuclear processes of repair of damaged DNA, chromatin remodeling, and transcription. Although many have sought specific DNA sequences bound by BRCA1, no such sequences have been reported.
openaire   +2 more sources