Results 81 to 90 of about 143,588 (347)
TP53 loss initiates chromosomal instability in fallopian tube epithelial cells
Disease Models & Mechanisms, 2021 High-grade serous ovarian cancer (HGSOC) originates in the fallopian tube epithelium and is characterized by ubiquitous TP53 mutation and extensive chromosomal instability (CIN).Daniel Bronder, Anthony Tighe, Darawalee Wangsa, Dali Zong, Thomas J. Meyer, René Wardenaar, Paul Minshall, Daniela Hirsch, Kerstin Heselmeyer-Haddad, Louisa Nelson, Diana Spierings, Joanne C. McGrail, Maggie Cam, André Nussenzweig, Floris Foijer, Thomas Ried, Stephen S. Taylor +16 moredoaj +1 more sourceFinding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer +10 morewiley +1 more sourceBreast cancer risk and 6q22.33: combined results from breast cancer association consortium and consortium of investigators on modifiers of BRCA1/2 [PDF]
, 2012 Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present Schürmann, Peter, Reed, M.W.R. (Malcolm), Noh, D-Y., Beesley, Jonathan, Severi, G., Hillemanns, Peter, Gold, B., G. E. M. Ausems, Margreet,, Ute Hamann (89879), Rookus, M.A., SWE-BRCA, Schuermann, Peter, Seal, Sheila, Lambrechts, Diether,, C. Southey, Melissa, Douglas, F., Schürmann, P. (Peter), Maria A Caligo, Hsiung, C-N., Frans B L Hogervorst, Wachenfeldt, A. (Anna) von, Natalia Antonenkova, Stig E Bojesen, Kosma, V.M., Mannermaa, Arto,, Pilar Zamora, M., Meindl, A., AOCS Study Grp, Heli Nevanlinna, Van Dorpe, Thijs, Anne-Sophie Dieudonne, B. Gomez Garcia, Encarna,, Schmidt, Marjanka K., Keun-Young Yoo, Couch, F.J. (Fergus), Georgia Chenevix-Trench (361), Lindor, Noralane,, Chang Claude, Jenny, Milne, R.L. (Roger), Melin, Beatrice,, Lambrechts, D., John L Hopper, Burwinkel, Barbara,, Brock, I.W. (Ian), Vachon, C., Broeks, A., Hopper, JL, D. P. Pharoah, Paul, van Asperen, Christi J., Aalfs, C.M. (Cora), Bogdanova, Natalia,, Douglas, F. (Fiona), Zachary Fredericksen (146612), Renwick, Anthony,, A. Agnarsson, Bjarni, Hatse, Sigrid,, Tollenaar, Robert A. E. M., John L. Hopper (89919), Jenny Chang-Claude (23562), D. Gareth Evans (154186), SWE-BRCA (154081), Hsiung, Chia-Ni, Loman, N. (Niklas), M. Braaf, Linde,, Gille, H.J.P. (Hans), Benitez, Javier,, A. Oldenburg, Rogier,, Verheus, Martijn, Linde M. Braaf (153949), Kataja, V, Paul D P Pharoah, Veli-Matti Kosma, Elliott, Graeme, Gille, Hans J. P., Yoo, K.-Y., Prokofieva, Daria, H. Karstens, Johann, Evans, D.G. (Gareth), J. Couch, Fergus,, Lorna Gibson, Benítez, J. (Javier), Gaudet, Mia M.,, Yu, JC, Ian Brock (153910), Van Dorpe, T., Pharoah, P.D., Bojesen, S.E., Hooning, MJ, Gómez García, EB, Braaf, L.M. (Linde), Kosma, V.-M., Lindblom, A., Ko, Yon-Dschun,, Spurdle, Amanda B, Ong, KR, Sei-Hyun Ahn, Kang, D., Wu, P-E., Johnson, N, Bermisheva, M., Yu, Jyh-Cherng,, Carol Chu, Yu, J., Wijnen, JT, Kauppinen, J, Frans B. L. Hogervorst (146390), Margreet G E M Ausems, Ko, Yon-Dschun, Ahn, Sei-Hyun,, Nordestgaard, B.G., Johann H Karstens, Karstens, Johann H., et al., Vachon, C, Van 't Veer, LJ, Anna von Wachenfeldt, Fredericksen, Z, Group, AOCS Study, Milne, R.L., Eeles, R., Hopper, J.L., Cox, A, G. Giles, Graham, Shen, C-Y., Hillemanns, P., Godwin, AK, Thilo Dörk (89882), Rabstein, S. (Sylvia), Bojesen, Stig E., Lesley McGuffog (153865), Paul D.P. Pharoah (154191), Holland, Helene,, Peock, Susan,, Dork, T., Milne, Roger L, Pharoah, P.D.P., Brauch, H, Mannermaa, A. (Arto), Reed, M.W.R., Tuomas Heikkinen (146567), Cox, Angela, Olson, J, Chu, Carol,, F. Easton, Douglas,, Olivia Fletcher, I. Rogov, Juri,, Davidson, R., Group, A.S., Mia M. Gaudet (146621), Sigrid Hatse (12560), Chu, C. (Carol), K. Godwin, Andrew,, Ian Brock, Luccarini, Craig, Johnson, Nichola, Wang, X. (Xianshu), Ausems, Margreet G.E.M., Giles, GG, Daria Prokofieva (154021), Sue Healey, Antonenkova, N, Cook, Margaret, Aalfs, CM, BCAC-CIMBA, Yu, J-C., Douglas, Fiona,, Peter Devilee (13431), Lindblom, Annika, Oldenburg, Rogier A, Annika Lindblom, Asperen, C.J. van, Vesa Kataja (89896), Baglietto, L, Bermisheva, Marina, Humphreys, Manjeet K., Ligtenberg, Marjolijn J., Justenhoven, C. (Christina), Xiaoqing Chen, Dieudonne, Anne Sophie, Kirchhoff, T., Gaudet, Mia M., Flyger, Henrik,, Braaf, Linde M., Hodgson, Shirley,, Zamora, M Pilar, Luccarini, C, M. Domchek, Susan,, Fletcher, O. (Olivia), Godwin, Andrew K, Broeks, A. (Annegien), Angela Cox (76913), Dork, Thilo,, Meindl, A, Kataja, V. (Vesa), Severi, G, Oldenburg, R.A., Brauch, H., Dunning, A.M. (Alison), Reed, Malcolm W. R., Gibson, L., Burwinkel, B., Susan Peock (154155), Dieudonné, A.-S. (Anne-Sophie), Hsiung, Chia Ni, Lambrechts, Diether, Gille, H.J., Bojesen, SE, Marina Bermisheva, Benítez, J., Kircchoff, T. (Tomas), Hamann, U. (Ute), Carol Chu (154167), Evans, Gareth; id_orcid, Javier Benítez, L. Hopper, John,, Hammet, F. (Fleur), Severi, G. (Gianluca), Giles, Graham G, Noh, DY, Prokofieva, Daria,, Chu, C., Dieudonne, AS, Prokofieva, D, Craig Luccarini (10535), Tomas Kirchhoff (102401), M. Aalfs, Cora,, Southey, Melissa C., Gaudet, MM, Fredericksen, Z., Oliver, C.T., Stig E. Bojesen (89870), Fletcher, Olivia,, Milne, RL, Loman, Niklas,, Marjolijn J. Ligtenberg (154122), M. Braaf, Linde, Antonenkova, N.N. (Natalia), Antoniou, A.C. (Antonis), Yoo, Keun-Young, Peock, S. (Susan), Braaf, L.M., Graham G. Giles (89916), Domchek, SM, Gómez García, Encarna B., Milne, Roger L., Douglas F. Easton (89956), Easton, Douglas F., Melissa C Southey, Diether Lambrechts (101772), Khusnutdinova, Elza,, Andrulis, I.L. (Irene), Caligo, MA, Ausems, M.G., Wang, X.S., Giles, G.G., Heikinen, T. (Tuomas), Hogervorst, F.B., Reed, MW, Hooning, Maartje J, Rahman, N, Beesley, Jonathan,, Humphreys, M.K. (Manjeet), Helene Holland, Peto, J., Craig Luccarini, Rookus, MA, Chen, Xiaoqing,, Hillemanns, P, Seynaeve, C.M. (Caroline), Nazneen Rahman, Gille, Hans JP, Tollenaar, R.A.E.M. (Rob), Pharoah, Paul D. P., Van 't Veer, L.J., Shen, CY, Garcia, E.B.G., Vesa Kataja, Dörk, T. (Thilo), Chenevix Trench, Georgia, Oliver, C.T. (Clare), Gille, Hans J P, Xiaoqing Chen (89898), Eccles, Diana,, Ahn, S.-H. (Sei-Hyun), Veer, L.J. van 't, Hogervorst, Frans B L, Caligo, Maria A, Meindl, Alfons,, Domchek, S.M., Noh, Dong-Young,, Margaret Cook (154156), Yu, J.-C., H. Karstens, Johann,, Devilee, Peter,, Gaudet, M.M., McGuffog, L. (Lesley), J. van Asperen, Christi,, Elliott, Graeme,, Jyh-Cherng Yu, Kirchhoff, T, Fergus J Couch, J. van Asperen, Christi, Bert Gold, Margolin, Sara, Alison M. Dunning (146796), Frost, D., Hopper, John L., Hamann, U, Hogervorst, Frans B. L., Antoniou, AC, Rosemarie Davidson, EMBRACE, BCAC-CIMBA, HEBON, AOCS Study Grp, kConFab, GENICA Network, SWE-BRCA, Van ‘t Veer, Laura J., Schuermann, Peter,, Davidson, R, L. Hopper, John, Luccarini, C. (Craig), Shan Wang-Gohrke (89910), Offit, K, Frost, D, Cook, J., Wang, XS, Wang, Xianshu, Peock, Susan, Gold, Bert, Khusnutdinova, E., Gille, J.J.P., Dorpe, T. (Thijs) van, Robert A.E.M. Tollenaar (154029), Dork, Thilo, Aalfs, Cora M., Cox, A. (Angela), Schuermann, P., Dieudonne, Anne-Sophie,, Ong, Kai-Ren, Yu, J-C. (Jyh-Cherng), Hammet, F., Kataja, Vesa, Turnbull, C. (Clare), van Asperen, CJ, Wu, Pei-Ei, Gibson, L.J. (Lorna), Beesley, J. (Jonathan), Nathanson, K.L. (Katherine), Noh, D.H., Rogier A. Oldenburg (154114), Henrik Flyger (146491), Wang, X, Dunning, Alison M, Baglietto, L. (Laura), Rogier A Oldenburg, Heikkinen, T., Wang, Xianshu,, Gareth Evans, D., Burwinkel, B, Broeks, A, Juul T Wijnen, B. Spurdle, Amanda,, Antonenkova, N., Tollenaar, RAEM, Cook, M., Pichert, G., Hamann, Ute, Kosma, Veli-Matti, Nordestgaard, Borge G.,, Agnarsson, B.A. (Bjarni), Askmalm, M.S., Turnbull, Clare,, Margolin, S. (Sara), Ausems, MG, Godwin, A.K. (Andrew), McGuffog, L., Tomas Kirchhoff, Jaana Kauppinen, Braaf, LM, Kirchhoff, Tomas,, Frost, Debra, Humphreys, MK, Pharoah, Paul DP, Harth, V. (Volker), Oliver, Clare T, Thijs Van Dorpe, Chang-Claude, J, J. P. Gille, Hans, Natalia Bogdanova, Kauppinen, Jaana, Cox, Angela,, Natalia Bogdanova (89885), Annegien Broeks, Marie Stenmark Askmalm (154086), Noh, D-Y. (Dong-Young), A. E. M. Tollenaar, Robert,, Caroline Seynaeve, Pesch, B. (Beate), Rookus, M.A. (Matti), Rahman, N., D. P. Pharoah, Paul,, Bojesen, Stig E, Natalia Antonenkova (154010), Anthony Renwick, Hooning, Maartje, Grp, AOCSS, Van Dorpe, Thijs,, Network, GENICA, Peto, J, Oldenburg, Rogier, Reed, Malcolm WR, T. Wijnen, Juul,, Severi, Gianluca,, Rosalind Eeles (154187), Karlsson, Per,, Fredericksen, Z. (Zachary), Johnson, N. (Nichola), Juri I Rogov, Julian Peto, Hogervorst, FB, Hooning, M.J. (Maartje), Melin, B, Susan M Domchek, Daria Prokofieva, Ligtenberg, M.J., G. E. M. Ausems, Margreet, Garcia, Encarna B. Gomez, Sheila Seal (146516), A. E. M. Tollenaar, Robert, Daehee Kang, Wu, Pei Ei, Shen, Chen-Yang,, Yoo, K.Y., Arias, JI, Graeme Elliott, Devilee, P, Encarna B Gómez García, José Ignacio Arias, Jackie Cook, Melissa C. Southey (89921), Clare T Oliver, Karlsson, P., Ong, K.R., A. Oldenburg, Rogier, Nordestgaard, BG, Wijnen, J.T., Sue Healey (41187), Meindl, Alfons, J. Ligtenberg, Marjolijn, Brock, Ian,, Hatse, S, Arto Mannermaa, L. Nathanson, Katherine,, Martijn Verheus, Margolin, S., Pichert, G, Heikkinen, Tuomas, Ko, Yon Dschun, Fletcher, O., Flyger, H., Bogdanova, Natalia, Kauppinen, J. (Jaana), Dieudonne, A.S., Ahn, Sei Hyun, Healey, S, Anne-Sophie Dieudonne (154000), Zamora, MP, Chen, Xiaoqing, Zamora, M.P. (Pilar), Jackie Cook (154176), Hillemanns, P. (Peter), Johann H. Karstens (146565), EMBRACE, Elliott, G, J. Van t Veer, Laura, Nevanlinna, H., Ahn, S.H., Daehee Kang (6451), Elza Khusnutdinova (146583), Nathanson, Katherine L, von Wachenfeldt, Anna, McGuffog, Lesley, M. Pilar Zamora (146494), van 't Veer, LJ (Laura), Rogov, JI, Kosma, VM, Yoo, Keun Young, Pharoah, Paul D P, kConFab (154048), Gold, Bert,, Shan Wang-Gohrke, M. Domchek, Susan, Dieudonne, A.-S., Xianshu Wang (146610), Matti A Rookus, Rabstein, S, Van ‘t Veer, Laura J, Nordestgaard, Borge G., Maartje J. Hooning (89934), Antoniou, A.C., Heikkinen, Tuomas,, Dong-Young Noh, AOCS Study Group, Holland, H. (Helene), Bert Gold (17043), Margolin, Sara,, Fletcher, Olivia, Eeles, Rosalind,, Seal, Sheila,, Wu, P.-E. (Pei-Ei), Pesch, B, Rahman, N. (Nazneen), Andrulis, IL, T. Oliver, Clare, Ko, Y-D., Pei-Ei Wu (153976), Ignacio Arias, Jose, Caroline Seynaeve (95368), Elza Khusnutdinova, Brüning, T. (Thomas), Stenmark Askmalm, Marie, L. Milne, Roger, A. Rookus, Matti, Chen, XQ, Gold, B, Mannermaa, A, Ko, Y-D. (Yon-Dschun), Gille, Hans J.P., EMBRACE (154152), Tollenaar, R.A.E.M., Ausems, Margreet GEM, Noh, Dong Young, Gille, HJP, Dieudonne, Anne-Sophie, Nevanlinna, H, Khusnutdinova, E, Caligo, M.A. (Maria), Kosma, Veli Matti, Marjolijn J Ligtenberg, Nevanlinna, H. (Heli), Niklas Loman (26096), Agnarsson, Bjarni A, Peter Hillemanns, Gianluca Severi (89918), Loman, N., Seynaeve, C, Chen, X., Katherine L Nathanson, Maria A. Caligo (154069), Van 't Veer, Laura J., Easton, D.F., Chang-Claude, Jenny, Per Karlsson, Godwin, Andrew K., L. Andrulis, Irene, Turnbull, C, Niklas Loman, Chenevix-Trench, G., Jaana Kauppinen (154064), Ausems, MGEM, Ligtenberg, M.J. (Marjolijn), Ausems, Margreet G. E. M., Manjeet K Humphreys, Marie Stenmark Askmalm, Schmidt, MK, Justenhoven, C, Zamora, M. Pilar, Van Dorpe, T, Hatse, S., Bjarni A Agnarsson, Gille, HJ, Healey, S. (Sue), Seynaeve, C., Kenneth Offit (63812), Cook, Margaret,, Ausems, M.G.E.M., Dong-Young Noh (6456), Couch, Fergus J, Shen, C.Y., Wang Gohrke, Shan, Gibson, Lorna,, Garcia, EBG, W. R. Reed, Malcolm,, Cora M Aalfs, Andrulis, Irene L, Antonenkova, Natalia,, Broeks, Annegien, Rogov, J.I. (Juri), Kang, Daehee, Chia-Ni Hsiung, B. L. Hogervorst, Frans,, Wang-Gohrke, Shan, Asperen, C.J. (Christi) van, Zachary Fredericksen, Janet Olson, Douglas, F, A. Caligo, Maria, Christi J van Asperen, Hsiung, C.-N., Børge G. Nordestgaard (89871), Dunning, A.M., Frost, Debra,, Debra Frost (154160), Yon-Dschun Ko (89880), Hammet, F, Braaf, Linde M, Hatse, S. (Sigrid), Harth, V, Noh, D.-Y., Jenny Chang-Claude, Gabriella Pichert, Verheus, M, Giles, Graham G., Georgia Chenevix-Trench, Nichola Johnson (146445), Fletcher, O, Lindblom, A. (Annika), Christi J. van Asperen (89901), Matti A. Rookus (154108), Kauppinen, Jaana,, Noh, D.Y., Gibson, Lorna, Offit, Kenneth, Andrew K. Godwin (131285), Debra Frost, Annegien Broeks (146385), Anna von Wachenfeldt (154090), Gille, H.J.P., Pharoah, Paul D.P., Linde M Braaf, Barbara Burwinkel (146479), Schürmann, P., Wang-Gohrke, S., Hsiung, C.N., Johnson, N., Ausems, M.G.E.M. (Margreet), Holland, H., Spurdle, Amanda B., Evans, D Gareth, Ligtenberg, Marjolijn J, Spurdle, AB, Flyger, Henrik, Pilar Zamora, M, Nordestgaard, Børge G., Domchek, S.M. (Susan), Diana Eccles, Irene L. Andrulis (107262), Gabriella Pichert (69450), Evans, DG, Kosma, V-M., Celine Vachon, Hogervorst, F.B.L. (Frans), Davidson, Rosemarie,, Tollenaar, Robert A E M, W. R. Reed, Malcolm, Julian Peto (146454), Gómez García, E.B., Hamann, Ute,, Encarna B. Gómez García (154147), Kataja, Vesa,, Rabstein, Sylvia, Agnarsson, Bjarni A., Shen, C.-Y., Ahn, Sei-Hyun, Wu, PE, Davidson, R. (Rosemarie), Ong, K.-R., Keun-Young Yoo (127429), HEBON (154096), Bogdanova, N, Melin, Beatrice, Hodgson, Shirley, Lesley McGuffog, Shirley Hodgson, T. Wijnen, Juul, A. Rookus, Matti,, Offit, Kenneth,, Robert A E M Tollenaar, Antoniou, Antonis C, Shirley Hodgson (154183), Askmalm, Marie Stenmark, Bermisheva, Marina,, Diana Eccles (154169), Andrew K Godwin, Hogervorst, FBL, Laura Baglietto, Eccles, D., Oliver, CT, Nichola Johnson, Wang-Gohrke, S, Ignacio Arias, J., Gaudet, Mia M, Hooning, Maartje J., Rogov, Juri I, Humphreys, Manjeet K, Katherine L. Nathanson (154077), K. Godwin, Andrew, Vachon, Celine,, Chang-Claude, J. (Jenny), Brock, I, Reed, Malcolm W.R., Per Karlsson (48671), Kenneth Offit, Børge G Nordestgaard, Evans, D. Gareth, Hsiung, CN, Hogervorst, Frans BL, Eccles, D, Nazneen Rahman (146509), Jonathan Beesley, Alfons Meindl (112058), Ong, Kai Ren, Peto, Julian, Susan M. Domchek (154078), Renwick, A., Turnbull, Clare, Peter Schürmann (89883), Luccarini, Craig,, Renwick, A. (Anthony), Pilar Zamora, M.,, Nathanson, K.L., Easton, Douglas F, Thilo Dork, Zamora, M.P., Hans J P Gille, Hsiung, C.-N. (Chia-Ni), Chenevix-Trench, G, GENICA Network, Diether Lambrechts, Baglietto, Laura,, Yu, Jyh Cherng, Anthony Renwick (146533), Ko, YD, Celine Vachon (89914), Roger L Milne, Humphreys, Manjeet K.,, Peter Devilee, Shen, C-Y. (Chen-Yang), McGuffog, Lesley,, Giles, G.G. (Graham), Domchek, Susan M., Baglietto, Laura, J. Hooning, Maartje,, Offit, K., Couch, FJ, Sara Margolin (146586), Evans, D.G., Lorna Gibson (153960), Laura J. Van ‘t Veer (153941), Ong, Kai-Ren,, Hammet, Fleur, Eeles, R, Nevanlinna, Heli, Cook, Jackie, Reed, M.W., Healey, S., Ligtenberg, MJ, Hodgson, S., Devilee, Peter, Benítez, J, Yu, J.C., Wu, P.E., Renwick, Anthony, Verheus, M. (Martijn), Rahman, Nazneen, Kang, D. (Daehee), Fergus J. Couch (146607), Schmidt, Marjanka K, Tollenaar, Robert AEM, Graham G Giles, Beesley, J, Schürmann, P, L. Nathanson, Katherine, Antonis C. Antoniou (146788), Juul T. Wijnen (154144), J. P. Gille, Hans,, K. Schmidt, Marjanka,, Olivia Fletcher (146442), Nevanlinna, Heli,, Beatrice Melin (113531), Bermisheva, M, Tuomas Heikkinen, Couch, Fergus J., Kosma, Veli-Matti,, Schmidt, M.K., Benítez, Javier, Wachenfeldt, A. von, Pei-Ei Wu, Beatrice Melin, Burwinkel, B. (Barbara), Barbara Burwinkel, Pesch, Beate, Holland, Helene, Vachon, C. (Celine), Martijn Verheus (154103), Douglas, Fiona, Couch, F.J., Arias Pérez, J.I. (José Ignacio), Alison M Dunning, Angela Cox, Hodgson, S.V. (Shirley), Dunning, Alison M., Sei-Hyun Ahn (153880), Mannermaa, A., Thijs Van Dorpe (153995), Hiltrud Brauch, Chen, X, Hamann, U., Chang-Claude, J., Peto, J. (Julian), Baglietto, L., Ahn, S.-H., Douglas F Easton, Manjeet K. Humphreys (146790), Fischer, H.-P., Wang, X., Ausems, Margreet G E M, Chenevix-Trench, Georgia,, Karstens, J.H. (Johann), Lambrechts, D. (Diether), Pichert, Gabriella,, Irene L Andrulis, Kai-Ren Ong (154173), Malcolm W.R. Reed (153922), Peter Hillemanns (89884), Bojesen, Stig E.,, Wijnen, Juul T, Holland, H, Chia-Ni Hsiung (153981), Khusnutdinova, E.K. (Elza), Verheus, M., Devilee, P. (Peter), Laura Baglietto (89917), Noh, Dong-Young, Brauch, H. (Hiltrud), Hans J.P. Gille (154139), Hoogerbrugge, N., Spurdle, A.B., Brock, I., Seal, S. (Sheila), Olson, J.E. (Janet), Caligo, Maria A., Jonathan Beesley (89897), Kang, Daehee,, Fischer, Hans Peter, Arto Mannermaa (89891), Arias, J.I., Veer, L.J. (Laura) van 't, Karstens, Johann H, Cook, Jackie,, Oldenburg, R.A. (Rogier), AOCS Study Group (154052), Lindor, N., M. Aalfs, Cora, Cora M. Aalfs (154133), Cook, J. (Jackie), Henrik Flyger, Kauppinen, J., L. Milne, Roger,, Oliver, Clare T., Agnarsson, B.A., Khusnutdinova, Elza, J. Ligtenberg, Marjolijn,, Seal, S., Fiona Douglas, Yon-Dschun Ko, Tollenaar, Robert A.E.M., Offit, K. (Kenneth), Harth, Volker, Javier Benitez (81758), Amanda B. Spurdle (47489), L. Andrulis, Irene,, Rosemarie Davidson (154164), Andrulis, Irene L., Fiona Douglas (154179), Chang-Claude, Jenny,, I. Rogov, Juri, Eccles, Diana, Stenmark Askmalm, M, F. Easton, Douglas, Oldenburg, Rogier A., Clare T. Oliver (154158), Davidson, Rosemarie, Prokofieva, D. (Daria), José Ignacio Arias (154038), Ahn, SH, Seynaeve, Caroline,, Yoo, K-Y. (Keun-Young), Renwick, A, Dunning, AM, Chen, X. (Xiaoqing), B. L. Hogervorst, Frans, Easton, DF, Noralane Lindor (154074), Kang, D, Elliott, G. (Graeme), Bogdanova, N.V. (Natalia), Graeme Elliott (153916), Hogervorst, F.B.L., Meindl, A. (Alfons), Annika Lindblom (26099), Bojesen, S.E. (Stig), Susan Peock, Eeles, Rosalind, Hopper, J.L. (John), Dunning, Alison M.,, Yu, Jyh-Cherng, Brüning, Thomas, Ko, Y.-D., Mia M Gaudet, Tobias, E.S., Juri I. Rogov (154016), Askmalm, M.S. (Marie), Stenmark Askmalm, Marie,, Chenevix-Trench, Georgia, Olson, J., Shen, Chen-Yang, Vachon, C.M., Justenhoven, Christina, Southey, M.C., Laura J Van 't Veer, Wijnen, Juul T., Aalfs, Cora M, Seal, S, Nathanson, KL, Godwin, A.K., Heikkinen, T, Vachon, Celine, Sara Margolin, kConFab, Ute Hamann, Fleur Hammet, Rogov, J.I., Lindor, Noralane, Marjanka K Schmidt, T. Oliver, Clare,, Noralane Lindor, Antoniou, Antonis C., Kai-Ren Ong, Reed, MWR, M Pilar Zamora, Andrulis, I.L., Wang-Gohrke, Shan,, Caligo, M.A., Karlsson, P, D Gareth Evans, Reed, Malcolm W R, Kosma, V-M. (Veli-Matti), Shen, Chen Yang, Margreet G.E.M. Ausems (154127), J. Hooning, Maartje, Brauch, Hiltrud, Verheus, Martijn,, Broeks, Annegien,, Elliott, G., Peto, Julian,, Wu, P.-E., Lambrechts, D, Wang-Gohrke, S. (Shan), Antonenkova, Natalia, Rogov, Juri I., Healey, Sue, J. Van t Veer, Laura,, Hammet, Fleur,, Agnarsson, BA, Chu, C, Yoo, KY, Chen, X.Q., Rookus, Matti A., Dieudonne, A-S., Wu, Pei-Ei,, Sheila Seal, Beesley, J., Cook, M, Nordestgaard, B.G. (Børge), Yoo, Keun-Young,, Clare Turnbull (146523), Karlsson, P. (Per), Maartje J Hooning, Ignacio Arias, Jose,, von Wachenfeldt, Anna,, Loman, N, Healey, Sue,, Cook, J, Bogdanova, N., Hiltrud Brauch (89877), Rahman, Nazneen,, Ahn, S-H., Van 't Veer, Laura J, Pichert, G. (Gabriella), Arias, José Ignacio, Chenevix-Trench, G. (Georgia), von Wachenfeldt, A, Gibson, L, Bjarni A. Agnarsson (154067), Melin, B., Hopper, John L, Jyh-Cherng Yu (146771), Lindblom, A, Eeles, R. (Rosalind), Pichert, Gabriella, Prokunina-Olsson, Ludmila, Askmalm, MS, Lindor, N.M. (Noralane) +999 morecore +1 more sourceInhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli +10 morewiley +1 more sourceH4K20me0 recognition by BRCA1-BARD1 directs homologous recombination in sister chromatids
Nature Cell Biology, 2019 Genotoxic DNA double-strand breaks (DSBs) can be repaired by error-free homologous recombination (HR) or mutagenic non-homologous end-joining1. HR supresses tumorigenesis1, but is restricted to the S and G2 phases of the cell cycle when a sister ...Kyosuke Nakamura, Giulia Saredi, Giulia Saredi, Jordan R. Becker, B. Foster, Nhuong V. Nguyen, Nhuong V. Nguyen, Tracey E. Beyer, Laura C Cesa, P. Faull, Saulius Lukauskas, T. Frimurer, J. R. Chapman, Till Bartke, Anja Groth +14 moresemanticscholar +1 more sourceMutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang +3 morewiley +1 more sourceGenetic Epidemiology of BRCA1 [PDF]
Cancer Biology & Therapy, 2004 Since the identification of the BRCA1 gene 10 years ago much has been learned about the role of the BRCA1 protein in cancer development. In particular, genetic and epidemiological approaches have informed about the spectrum of mutations that occur in the gene and the prevalence, penetrance, and phenotype associated with these mutations in various ...openaire +2 more sources
