Results 71 to 80 of about 143,588 (347)
Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns +10 morewiley +1 more sourceLog odds of carrying an Ancestral Mutation in BRCA1 or BRCA2 for a defined personal and family history in an Ashkenazi Jewish woman (LAMBDA) [PDF]
, 2003 INTRODUCTION: Ancestral mutations in BRCA1 and BRCA2 are common in people of Ashkenazi Jewish descent and are associated with a substantially increased risk of breast and ovarian cancer.Ellen Solomon, Fisher, S A, Lewis, C M; id_orcid, Lewis, CM, Southey, MC, John L Hopper, Hodgson, SV, Venter, DJ, Michael Friedlander, Hopper, JL, Hopper, J L, Solomon, E, Bankier, A, Hooper, J L, Cathryn M Lewis, Tucker, K, Melissa C Southey, Southey, M C, Lesley Andrews, Friedlander, M, Carmel Apicella, Hodgson, S V, Fisher, SA, Katherine Tucker, Venter, D J, Agnes Bankier, Apicella, C, Deon J Venter, Andrews, L, Shirley V Hodgson, Sheila A Fisher +30 morecore +1 more sourceKDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan +16 morewiley +1 more sourceCommon breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
, 2011 The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by ...Donaldson, A., Danièle Muller, Mark H Greene, L Mai, Phuong,, SWE-BRCA, Madeleine MA Tilanus Linthorst, Engel, C., Pankratz, Vernon, Murray, A, Muy-Kheng Tea, Barrowdale, D., Paul DP Pharoah, Wachenfeldt, v.A., Lynch, Henry, Maria A Caligo, Network, OCG, Wachenfeldt, A. (Anna) von, Anne Marie Gerdes, Boutry-Kryza, Nadia, Barkardottir, Rosa B, F Easton, Douglas,, Varon-Mateeva, Raymonda, Investigators, K, Tilanus-Linthorst, Madeleine M. A., Ozcelik, Hilmi, Pascal Pujol, Breast Canc Family Registry, Kast, K, Kets, C.M. (Marleen), Raymonda Varon Mateeva, Wachenfeldt, V., Martine Dumont, Ejlertsen, B. (Bent), Meindl, A., K Godwin, Andrew, Gschwantler-Kaulich, D. (Daphne), Viel, Alessandra, Meijers-Heijboer, Hanne E.J., Heli Nevanlinna, Patricia A. Ganz, de la Hoya, Miguel, Andrew K. Godwin, Couch, F.J. (Fergus), Skytte, Anne-Bine, Paolo Peterlongo, Janavicius, Ramunas,, Bonanni, Bernardo, Ana Osorio, John L Hopper, Viel, A., Y Karlan, Beth,, Arnold, N, Soller, M., Mai, P.L. (Phuong), Caldes, Trinidad,, Hopper, JL, Olopade, Olufunmilayo, Ruehl, Ina, Gross, J. (Jenny), Eason, J., Chung, Wendy K., Kirsten B. Moysich, A. C. Breast Cancer Family Registry Antoniou, Wachenfeldt, VA, Arver, Brita, A Ganz, Patricia, Pujol, P, Brita Arver, Niederacher, D, Hansen, Thomas V.O., Miguel de la Hoya, Radice, Paolo,, Mark Sherman, Rookus, Matti, Sherman, Mark, Berthet, Pascaline, Benitez, Javier,, Verheus, Martijn, François Cornelis, Godino, J, Neuhausen, S.L. (Susan), Douglas F. Easton, Mulligan, A.M., S Pankratz, Vernon, Osorio, A, Hardouin, A, Os, Theo V., Antonis C. Antoniou, Rebbeck, Timothy R, Esther M John, Mazoyer, S, Aittomäki, K., Evans, D.G. (Gareth), Blanco, I, Rosa B. Barkardottir, Benítez, J. (Javier), Lee, A, Papi, Laura, Muller, D, Gómez García, EB, Kirsten B Moysich, Deissler, Helmut,, van Os, Theo, Gordon Glendon, Lebrun, Marine, Michel Longy, Spurdle, Amanda B, Antoniou, Antonis, Frances P. O'Malley, Pujol, Pascal,, Greene, Mark H., Ganz, Patricia A, Cattaneo, E., Iván Muñoz-Repeto, Berthet, P., Daphne Gschwantler-Kaulich, Gross, Jenny, Henry T. Lynch, J Louise Jones, Susan L Neuhausen, Buys, Saundra M, Mortemousque, Isabelle, Coupier, Isabelle,, Pertesi, M, Fricker, J-P, Ignacio Blanco, Hansen, T.V., Donaldson, A, Peissel, Bernard,, Fredericksen, Z, Henriksson, K, Eeles, R., van Der Luijt, Rob, Niederacher, Dieter,, Hopper, J.L., Godwin, AK, Fassy-Colcombet, M. (Marion), Tilanus-Linthorst, Madeleine M.A., Schäfer, D., Eason, J. (Jacqueline), Peock, Susan,, Cornelis, F, Peterlongo, Paolo, Evans, D. Gareth; id_orcid, Glendon, Gordon,, Pharoah, P.D.P., Dieter Schäfer, Varon-Mateeva, R, Olopade, O.I., Kruse, Torben A, Ganz, P.A. (Patricia), Ros Eeles, Chung, W., Terry, Mary, Beattie, M., Leone, Melanie,, Montagna, M., Javier Godino, Robson, Mark,, Durán, M., Kruse, Torben A., Gregory, H, Noralane M. Lindor, Gadzicki, D., Lindor, Noralane M, Pankratz, Vernon S, Davidson, R., Fricker, Jean-Pierre, Soucy, Penny, Susan J. Ramus, Raymonda Varon-Mateeva, Berthet, P. (Pascaline), Jensen, Uffe, Birk, Tilanus-Linthorst, M.M.A. (Madeleine), Simard, J. (Jacques), Miron, Alexander F., Manoukian, S. (Siranoush), Julian Barwell, Kruse, T.A., Godino, J. (Javier), van Os, Theo,, Os, Theo van, Robson, Mark, Sue Healey, Frances P O'Malley, Gerdes, Anne-Marie, GEMO Study Collaborators, Madeleine MA Tilanus-Linthorst, Bonanni, Bernardo,, Singer, Christian, Caux-Moncoutier, V. (Virginie), Engel, Christoph, Tognazzo, Silvia,, Kauff, N. (Noah), Pertesi, Maroulio,, Torben A. Kruse, Adlard, Julian,, Aittomäki, K. (Kristiina), Sakr, R. (Rita), Ramunas Janavicius, Buys, SM, Ottini, Laura,, Schäfer, Dieter, Marie Stenmark-Askmalm, Soller, Maria,, Janavicius, R, Gevensleben, H, Heidrun Gevensleben, Rookus, M, Hansen, Thomas V., Godwin, Andrew K, Christian Sutter, Meindl, A, DAndrea, Emma,, Karlan, B.Y., Muy Kheng Tea, Sevenet, N., Mai, Phuong L, Toland, Amanda E, Dieter Niederacher, Caux-Moncoutier, V, Benítez, J., Wijnen, J., Muller, Danièle, Hamann, U. (Ute), Ottini, Laura, Moysich, Kirsten B., Gross, J, Madeleine M. A. Tilanus Linthorst, Iván Muñoz Repeto, E Side, Lucy, Susan J Ramus, Henry T Lynch, Arver, B. (Brita Wasteson), Muller, D.W. (Danièle), Isaacs, Claudine, Barrowdale, Daniel,, Esther M. John, Peterlongo, P, Southey, Melissa C., Fredericksen, Z., Hansen, Thomas vO., Olopade, Olufunmilayo I, Bhatia, Jasmine, Wijnen, J, Heinritz, W., Mai, PL, Ozcelik, H, Rosa B Barkardottir, Manoukian, S., Antoniou, A.C. (Antonis), Gerdes, Anne-Marie,, Peock, S. (Susan), Thomassen, M. (Mads), Gómez García, Encarna B., Domchek, SM, Daniel Barrowdale, Henriksson, Karin, Kientz, Caroline,, Caux-Moncoutier, Virginie, Gaudet, M., Kets, C Marleen,, Sevenet, Nicolas,, Kauff, N, Adlard, J.W. (Julian), Adlard, J, Lee, A. (Andrew), Mortemousque, Isabelle,, Easton, Douglas F., Melissa C Southey, Ruehl, I. (Ina), Léoné, Mélanie, Skytte, A.-B. (Anne-Bine), Emma McCann, Lebrun, M., Bernard Peissel, Andrulis, I.L. (Irene), Lazaro, C, Caligo, MA, Hanne EJ Meijers-Heijboer, Os, Theo v, Wang, X.S., Caux-Moncoutier, V., Houghton, C., Heikinen, T. (Tuomas), Jacqueline Eason, Deissler, H. (Helmut), Schmutzler, RK, Anne Bine Skytte, Gadzicki, D. (Dorothea), Saundra M. Buys, Donaldson, Alan,, Gerdes, A-M. (Anne-Marie), O'Malley, Frances, F Miron, Alexander,, Maria A. Caligo, Weitzel, JN, Seynaeve, C.M. (Caroline), Sutter, C., Pharoah, Paul D. P., Ozcelik, H. (Hilmi), Anne-Marie Gerdes, Helmut Deissler, Gaudet, Mia,, Finn C Nielsen, F Miron, Alexander, Garcia, E.B.G., Rookus, M., Eccles, Diana,, Coupier, I., Fassy-Colcombet, Marion, Caligo, Maria A, Toland, Amanda E., Penny Soucy, L Nathanson, Katherine, McCann, E., Mulligan, Anna Marie, Mads Thomassen, Spurdle, Amanda, Meindl, Alfons,, C Southey, Melissa,, Domchek, S.M., Deissler, H., Mazoyer, S., Eeles, Ros, McGuffog, L. (Lesley), Tea, Muy-Kheng, Preisler-Adams, Sabine,, Gadzicki, D, Fergus J Couch, Hansen, TV, Frost, D., Terry, MB, Marcel R Nelen, Vernon S Pankratz, Marion Fassy Colcombet, Os, T. van, Neuhausen, Susan, Hopper, John L., Hansen, TVO, B Barkardottir, Rosa,, Hamann, U, Conxi Lazaro, Schoenbuchner, Ines, Imyanitov, E., Antoniou, AC, Rosemarie Davidson, Isaacs, C., Wachenfeldt, von A, Soller, M, Pujol, Pascal, Davidson, R, Donaldson, Alan, Eason, Jacqueline,, Adlard, Julian, Offit, K, Sherman, M.E. (Mark), Donaldson, A. (Alan), Frost, D, Daly, Mary B, Schaefer, Dieter, Cook, J., Wang, XS, Wang, Xianshu, Ottini, L, Caligo, Maria, Peock, Susan, Hansen, Thomas v, Karlan, BY, Moysich, Kirsten B, Rhiem, K, Mazoyer, S. (Sylvie), E. M. John, Yan, M. (Max), Benitez, Javier, Boutry-Kryza, N, Muñoz-Repeto, I., Papi, L., Ontario Canc Genetics Network, Ding, Yuan,, Lee, A., Nielsen, FC, Luijt, R.B. (Rob) van der, Mary B. Daly, John, EM, Preisler-Adams, S. (Sabine), Barkardottir, R.B. (Rosa), Wachenfeldt, von Anna, Mulligan, AM, Sakr, R., Chung, W. (Wendy), Caldes, T. (Trinidad), Kientz, C, Nathanson, K.L. (Katherine), Izatt, Louise, Savarese, A., Pankratz, V.S. (Shane), Os, Theo, Rita K. Schmutzler, Wang, X, Muller, D., Sutter, C, Gadzicki, Dorothea,, Kientz, Caroline, Manoukian, Siranoush,, Ganz, P.A., Lalloo, F., Heikkinen, T., Alan Donaldson, Wang, Xianshu,, C Marleen Kets, Evans, D G, Mortemousque, I. (Isabelle), Houghton, Catherine,, Ontario Cancer Genetics Network, Adlard, J., Loris Bernard, Bhatia, Jasmine,, Os, Theo, Van, Hamann, Ute, Yan, Max, Cornelis, F. (Franco̧is), Fassy-Colcombet, M., E Tomlinson, Gail, Singer, Christian F, Kruse, T.A. (Torben), Norbert Arnold, Kets, C Marleen, Easton, Douglas, Jean Pierre Fricker, Godwin, A.K. (Andrew), McGuffog, L., Blanco, I., Peissel, Bernard, Stenmark-Askmalm, M., Schaefer, Dieter,, Sevenet, N. (Nicolas), Sevenet, N, Miron, A. (Alexander), P OMalley, Frances,, Radice, Paolo, Frost, Debra, Ganz, PA, van der Luijt, RB, Jeffrey N Weitzel, Fricker, J.P., Arnold, Norbert, L Andrulis, Irene,, Rebbeck, T, Kast, Karin, Pharoah, Paul DP, Ramus, S.J., Barkardottir, Rosa, Caldes, T., Daly, Mary B., Gregory, Helen,, Sakr, R, Murray, A., Miron, AF, Ruehl, Ina,, Sinilnikova, OM, Maroulio Pertesi, Jones, J Louise, Meijers-Heijboer, Hanne E, Fricker, Jean-Pierre,, Chun Ding, Yuan, Side, L.E., Boutry-Kryza, Nadia,, Ramus, Susan J, C. Marleen Kets, Noah Kauff, Ozcelik, H., Caroline Seynaeve, Trinidad Caldes, Daphne Gschwantler Kaulich, Soucy, Penny,, Stoppa-Lyonnet, D., Peterlongo, P. (Paolo), Munoz-Repeto, Ivan,, Rookus, M.A. (Matti), A Ganz, Patricia,, Soller, Maria, Side, Lucy E, Dorkins, H, Daly, M.B. (Mary), Henriksson, Karin,, D P Pharoah, Paul,, Glendon, Gordon, A Kruse, Torben,, van Os, T., Wijnen, Juul, McCann, Emma, H Greene, Mark, Karlsson, Per,, Karin Kast, Fredericksen, Z. (Zachary), Huw Dorkins, Caldes, T, Hoya, M. (Miguel) de La, Paul D. P. Pharoah, Alexander F. Miron, Cattaneo, Elisa, Stenmark-Askmalm, M, D P Pharoah, Paul, Gail E. Tomlinson, Susan M Domchek, Stoppa-Lyonnet, D, Tilanus-Linthorst, Madeleine M A, Peterlongo, P., Lázaro, C. (Conxi), Garcia, Encarna B. Gomez, Barwell, Julian, John, Esther, Greene, Mark H, Gevensleben, H. (Heidrun), Stoppa-Lyonnet, D. (Dominique), Bent Ejlertsen, Montagna, M, Beattie, Mary, Ejlertsen, B, Caux-Moncoutier, Virginie,, Viel, A. (Alessandra), Anneliese Fink-Retter, Peterlongo, Paolo,, Nelen, Marcel R, Encarna B Gómez García, Mulligan, Anna, Marie, Jackie Cook, Dumont, M., Neuhausen, Susan L, Terry, Mary, Beth, Karlsson, P., Lee, Andrew Roger, Barbara Wappenschmidt, Family Registry, Breast Cancer, Meindl, Alfons, Terry, Mary,, Neuhausen, S.L., L Neuhausen, Susan, Lazaro, Conxi, Ejlertsen, Bent,, Evgeny Imyanitov, Anna Marie Mulligan, Terry, Mary B., Soucy, P., Eason, J, Martijn Verheus, Tomlinson, Gail E, Arver, Brita,, Gevensleben, Heidrun, Heikkinen, Tuomas, Toland, Amanda, Isabelle Mortemousque, Tilanus-Linthorst, MMA, Dorkins, Huw, Healey, S, McCann, Emma,, Aittomäki, Kristiina, Heinritz, W. (Wolfram), Couch, Fergus, I Olopade, Olufunmilayo, Tognazzo, S., Tomlinson, G.E., EMBRACE, Dorothea Gadzicki, Hardouin, Agnès, Preisler-Adams, S., Toland, A.E., Greene, M.H., Karlan, Beth, Nevanlinna, H., Coupier, Isabelle, Hoya, M. de la, Nathanson, Katherine L, von Wachenfeldt, Anna, Pasini, B, Sutter, Christian,, A Caligo, Maria,, McGuffog, Lesley, Lazaro, C (Conxi), Fink-Retter, A. (Anneliese), Hilmi Ozcelik, Collaborators, GEMOS, Pharoah, Paul D P, Lee, Andrew, Sakr, Rita, Jensen, UB, Simard, Jacques,, Chung, Wendy,, Ruehl, I., Mazoyer, Sylvie, Christian F. Singer, Olga M Sinilnikova, B Barkardottir, Rosa, Hopper, John, Jones, J L, Schmutzler, Rita, Antoniou, A.C., Heikkinen, Tuomas,, Claudine Isaacs, Boutry-Kryza, N., M Buys, Saundra, Singer, CF, Papi, Laura,, Ding, Yuan C., Hardouin, Agnes,, Blanco, Ignacio, Lynch, Henry T., Mulligan, Anna,, Chun Ding, Yuan,, Ottini, L. (Laura), Andrulis, IL, Fricker, J.P. (Jean Pierre), Susan M. Domchek, Breast Cancer Family Registry, Pankratz, VS, Sherman, M, Stenmark Askmalm, Marie, Lynch, H.T., Side, L. (Lucy), Lazaro, Conxi,, Meijers-Heijboer, E.J. (Hanne), Goldgar, D., Nathanson, Katherine, Tea, Muy Kheng, Aittomaki, Kristiina,, McCann, E. (Emma), Karlan, B.Y. (Beth), Siranoush Manoukian, Nevanlinna, H, Ramus, Susan, Nelen, MR, Schoenbuchner, I., Terry, Mary B, Pascaline Berthet, Caligo, M.A. (Maria), Goldgar, D, Mark H. Greene, Ramus, Susan J., Nevanlinna, H. (Heli), Sylvie Mazoyer, Fink-Retter, A., Meijers-Heijboer, Hanne E J, Hanne E. J. Meijers Heijboer, Ramus, Susan J,, Moysich, Kirsten, Zaffaroni, Daniela, Kets, C.M., Pankratz, V.S., Preisler-Adams, Sabine, Seynaeve, C, Katherine L Nathanson, Hansen, Thomas V O, Simard, J., Easton, D.F., Nelen, Marcel, Sabine Preisler-Adams, Per Karlsson, Bernard, L, Godwin, Andrew K., Jensen, Uffe,, Mary Beth Terry, Radice, P, Gevensleben, Heidrun,, Jones, J.L. (J Louise), Weitzel, J.N. (Jeffrey), F Singer, Christian,, Weitzel, J.N., B Daly, Mary,, Chenevix-Trench, G., Daly, Mary, Sinilnikova, O.M., Terry, Mary Beth, Ding, Y.C., Glendon, G, Hansen, T.V.O. (Thomas), Virginie Caux Moncoutier, Lucy E. Side, Marie Stenmark Askmalm, Lazaro, C., Hansen, Thomas V. O., kConFab Investigators, Imyanitov, E, Montagna, Marco,, Christoph Engel, F Easton, Douglas, Skytte, Anne Bine, Moysich, K.B. (Kirsten), Healey, S. (Sue), Seynaeve, C., Fox, S.B. (Stephen), Bernard, Loris, Kauff, N., van der Luijt, Rob B., Beth Terry, Mary,, Couch, Fergus J, Mai, Phuong, Lebrun, M. (Marine), van der Luijt, Rob B,, Garcia, EBG, Barkardottir, Rosa B., Andrulis, Irene L, Alex Murray, Kristiina Aittomäki, Ganz, Patricia, Olga M. Sinilnikova, Wappenschmidt, B, Fiebig, B. (Britta), Zachary Fredericksen, Max Yan, Niederacher, D., H Greene, Mark,, Fricker, JP, Side, Lucy, Mia Gaudet, Fassy-Colcombet, Marion,, A Caligo, Maria, DAndrea, Emma, Greene, MH, Pujol, P. (Pascal), Pharoah, Paul D, Frost, Debra,, Karlan, Beth Y, Saundra M Buys, van der Luijt, R.B., Yan, M, Kauff, Noah,, Soller, M. (Maria), Tilanus-Linthorst, M.M.A., Verheus, M, Beth Terry, Mary, Georgia Chenevix-Trench, Osorio, Ana, Greene, M.H. (Mark), Offit, Kenneth, Houghton, C. (Catherine), T Lynch, Henry,, Nielsen, Finn, de Al Hoya, Miguel, M Lindor, Noralane,, Ozcelik, Hilmi,, Debra Frost, Agnès Hardouin, Barwell, J., Varon-Mateeva, Raymonda,, M Buys, Saundra,, Miron, A.F., Jones, JL, Thomas vO Hansen, Pharoah, Paul D.P., Jensen, Uffe B, Southey, Melissa, Janavicius, Ramunas, Lynch, H. (Henry), Barrowdale, D, O'Malley, F.P., Beattie, M, L Hopper, John,, de la Hoya, M., Spurdle, Amanda B,, Spurdle, Amanda B., Kast, K., Rob B van der Luijt, Tea, Muy-Kheng,, Heinritz, W, Nielsen, Finn C, Evans, D Gareth, Bonanni, B, Spurdle, AB, Greene, Mark, Soucy, P, van Os, T, Lynch, HT, Bernard, Loris,, Melissa C. Southey, Domchek, S.M. (Susan), Diana Eccles, Os, Theo,, Alexander F Miron, Olufunmilayo I. Olopade, Jasmine Bhatia, Moysich, K.B., Tomlinson, Gail E., Evans, DG, John, E.M. (Esther), Davidson, Rosemarie,, B Moysich, Kirsten, Jones, J. Louise, Rebbeck, Tim,, Gómez García, E.B., Hamann, Ute,, Rebbeck, Tim, Peissel, B. (Bernard), Neuhausen, Susan L., Savarese, A, Jeffrey N. Weitzel, K Godwin, Andrew,, Olufunmilayo I Olopade, Isaacs, C. (Claudine), Fink-Retter, Anneliese, Cattaneo, Elisa,, Davidson, R. (Rosemarie), Gomez Garcia, EncarnaB,, Isabelle Coupier, Yan, Max,, Fiebig, B, Engel, Christoph,, Schaefer, D, P OMalley, Frances, Lesley McGuffog, Olopade, Olufunmilayo I., K Schmutzler, Rita, Offit, Kenneth,, Antoniou, Antonis C, Longy, M., Munoz-Repeto, I, Kientz, C., Andrew K Godwin, T Lynch, Henry, Phuong L. Mai, Amanda E. Toland, Eccles, D., Pasini, B., Zaffaroni, D., Britta Fiebig, Thomassen, Mads,, Fox, Stephen,, Fox, S., Katherine L. Nathanson, Mazoyer, Sylvie,, Fiebig, Britta, Lynch, Henry T, Gross, Jenny,, Sherman, M., Gerdes, A.-M., Thomassen, Mads, Meijers-Heijboer, HEJ, Side, Lucy E., Tilanus-Linthorst, Madeleine, Jones, J Louise,, Kruse, TA, Bhatia, J., Preisler-Adams, S, Barbara Pasini, CIMBA, Weitzel, Jeffrey N, Anna Wachenfeldt, von, Rebbeck, T., Thomas V. O. Hansen, Kenneth Offit, Mai, P.L., Yuan Ding, Evans, D. Gareth, A Kruse, Torben, Gomez Garcia, EncarnaB, Noralane M Lindor, Sakr, Rita,, Imyanitov, E.N. (Evgeny), Eccles, D, Schmutzler, R.K. (Rita), Kets, C. Marleen, Rob B. van der Luijt, Fink-Retter, Anneliese,, Kets, C M, Murray, Alex,, M John, Esther,, Nathanson, K.L., Robson, M., Easton, Douglas F, Gómez García, Encarna, Emma D'Andrea, Chung, W, Coupier, I. (Isabelle), Stenmark-Askmalm, M. (M.), Christian F Singer, Niederacher, Dieter, Chenevix-Trench, G, Marine Lebrun, Zaffaroni, Daniela,, Arver, B., Schoenbuchner, I. (Ines), Moysich, KB, Ruehl, I, Marion Fassy-Colcombet, Tognazzo, S. (Silvia), Mulligan, Anna Marie,, Rhiem, K. (Kerstin), Jensen, Uffe B., McGuffog, Lesley,, Eeles, Ros,, Hansen, Thomas vO, Anna Wachenfeldt, von,, C Antoniou, Antonis,, Lund University., van Wijnen, J (Juul), D. Gareth Evans, Dominique Stoppa Lyonnet, Domchek, Susan M., Pankratz, Vernon S., Marcel R. Nelen, Offit, K., Couch, FJ, Domchek, Susan M,, Evans, D.G., Jensen, Uffe, Meijers-Heijboer, Hanne EJ, Dorkins, H. (Huw), Eeles, R, Nevanlinna, Heli, Ina Ruehl, Cook, Jackie, Schäfer, D, Dorkins, Huw,, Leone, M, Healey, S., John L. Hopper, Jacques Simard, Mary Beattie, B Moysich, Kirsten,, Wendy Chung, Savarese, A. (Antonella), Buys, Saundra M., Engel, C, Peissel, B., Meijers-Heijboer, Hanne, Simard, Jacques, C Antoniou, Antonis, Buys, S.M., S Pankratz, Vernon,, Sutter, C. (Christian), Toland, A.E. (Amanda), Verheus, M. (Martijn), Blanco, Ignacio,, Glendon, G., Y Karlan, Beth, Ding, Yuan, Bhatia, J, L Hopper, John, Stenmark-Askmalm, Marie, Louise Izatt, Szabo, Csilla, O'Malley, F.P. (Frances), L Neuhausen, Susan,, Sabine Preisler Adams, Wolfram Heinritz, Glendon, G. (Gord), Hardouin, A. (Agnès), Amanda E Toland, Nevanlinna, Heli,, Tuomas Heikkinen, Izatt, Louise,, Couch, Fergus J., Lindor, N.M., Couch, Fergus J,, Ramus, SJ, Benitez, J, Pertesi, M. (Maroulio), J. Louise Jones, Helen Gregory, Mulligan, Anna M, Houghton, C, Szabo, C, Kientz, C. (Caroline), Tilanus-Linthorst, Madeleine M A,, Couch, F.J., Izatt, L. (Louise), Nadia Boutry-Kryza, Skytte, Anne-Bine,, Jenny Gross, Montagna, Marco, Hamann, U., Duran, M, Tilanus - Linthorst, Madeleine, Ding, Yuan C, Toland, AE, Douglas F Easton, Rookus, Matti,, Pasini, B. (Barbara), Wang, X., Chenevix-Trench, Georgia,, Coupier, I, Szabo, C., Matti Rookus, Theo Os, Irene L Andrulis, Mulligan, Anna, Daly, MB, Eason, Jacqueline, Aittomaki, K, Tognazzo, S, Karlan, Beth Y., Dumont, Martine,, Verheus, M., Léone, M. (Mélanie), Godino, Javier, Laura Ottini, Hansen, Thomas V O,, Weitzel, Jeffrey N., Buys, S.S. (Saundra), Izatt, L. +999 morecore +1 more sourceProteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi +10 morewiley +1 more sourceCirculating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman +10 morewiley +1 more sourceBRCA1 and BRCA2 mutations in a population-based study of male breast cancer
, 2001 Background: The contribution of BRCA1 and BRCA2 to the incidence of male breast cancer (MBC)
in the United Kingdom is not known, and the importance of these genes in the increased risk of female
breast cancer associated with a family history of breast ...Bruce AJ Ponder, Julian M Lipscombe, Joanna M Ward, Basham, VM, Easton, DF, Ward, JM, Ponder, BAJ, Victoria M Basham, Simon A Gayther, Paul DP Pharoah, Lipscombe, JM, Douglas F Easton, Pharoah, PDP, Gayther, SA +13 morecore +1 more source
