Results 101 to 110 of about 66,967 (213)
International Journal of Cancer, Volume 158, Issue 6, Page 1617-1627, 15 March 2026.What's new? PARP inhibitors are effective in patients with inactivating alterations in the BRCA1/2 genes across tumor types. However, the efficacy of PARP inhibitors in patients with other inactivated homologous recombination repair genes remains unclear. This knowledge gap and discrepancies in EMA/FDA approvals highlight the need for better biomarkers.
Ilse A. C. Spiekman +15 more
wiley +1 more source
International Journal of Cancer, Volume 158, Issue 6, Page 1675-1689, 15 March 2026.What's new? CATCH is a prospective precision oncology registry trial that harnesses whole‐genome/exome‐ and RNA‐sequencing to enable actionable biomarker detection in metastatic breast cancer patients of any subtype. The data of the first 412 consecutive patients with completed follow‐up in this real‐world, single‐center patient cohort provide robust ...
Mario Hlevnjak +31 more
wiley +1 more source
Entwicklung und Validierung eines Bioassays zum Nachweis induzierter Genaktivität für den Einsatz auf der Internationalen Raumstation [PDF]
, 2007 Neben der fehlenden Schwerkraft stellt die Strahlenbelastung des Astronauten einen limitierenden Faktor für den Langzeitaufenthalt des Menschen im Weltraum dar.
Arenz, Andrea
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Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma
Pediatric Blood &Cancer, Volume 73, Issue 3, March 2026.ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack +12 more
wiley +1 more source
Molecular Oncology, Volume 20, Issue 3, Page 709-726, March 2026.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Molecular Oncology, Volume 20, Issue 3, Page 838-849, March 2026.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
The Rad51 function : An Evo/Reco approach In Arabidopsis [PDF]
, 2010 In an attempt to better understand the " qualities " of Rad51, we set up an Evo/Devo, or Evo/Reco, approach to examine the properties of Rad51 proteins from diverse origins in Arabidopsis.
Delacote, Fabien +5 more
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Molecular Oncology, Volume 20, Issue 3, Page 779-803, March 2026.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Mapping genetic interactions in cancer: a road to rational combination therapies. [PDF]
, 2019 The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2 ...
Krogan, Nevan J, Tutuncuoglu, Beril
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NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease
Advanced Science, Volume 13, Issue 14, 9 March 2026.NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang +18 more
wiley +1 more source