Results 131 to 140 of about 44,419 (235)

Identification and purification of a soluble region in the breast cancer susceptibility protein BRCA2

, 2005
The BRCA2 gene encodes a large multidomain protein of 3418 residues. Studies to elucidate the mechanisms by which BRCA2 prevents tumour formation have been largely restricted by the size of the protein.
Finch, David, David Finch, Webb, Michelle, Michelle Webb   +3 more
core   +1 more source

Sublineage‐Specific A45S Polymorphism Alters the Biological Function of the Human Papillomavirus 11 E7 Protein

Journal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT The E7 oncoprotein of human papillomavirus (HPV) plays a crucial role in viral pathogenesis and replication. Although it is generally highly conserved across HPV genotypes, naturally occurring E7 variants can display functional differences that may affect viral persistence, oncogenic potential, and host cellular responses.
Zsolt Barnabás Éles, Leila Rahmani, Eszter Gyöngyösi, Krisztina Szarka, István Rebenku, György Veress, Tamás Major, József Kónya, Anita Szalmás   +8 more
wiley   +1 more source

STATUS METILASI GEN BRCA1 GEN BRCA2 EKSPRESI PROTEIN BRCA1 PROTEIN BRCA2 HUBUNGANNYA DENGAN TERJADINYA TUMOR EPITELIAL OVARIUM DERAJAD DIFERENSIASI JENIS HISTOPATOLOGI STADIUM DAN SURVIVAL PENDERITA KANKER EPITELIAL OVARIUM

, 2013
Cancer initiation and progression are controlled by genetic and epigenetic events. Cancer develops through multistep process in which the genomes of cancer cells mutate in several groups of genes such as proto-oncogen, tumor suppresor genes and other ...
, Prof. dr. H. Djaswadi Dasuki SpOG(K),, , Heru Pradjatmo, dr.,Sp.OG(K).,M.Kes.   +1 more
core  

Functional analysis of BRCA2 p.Val2985_Thr3001del.

, 2013
(A) Schematic representation of GST-BRCA2 recombinant proteins. Wild-type and mutant BRCA2 fragments, encoding the DBD and the N-terminal region, were cloned into pGEX4T1 vector to express GST-BRCA2 fusion proteins under the control of lacUV5 promoter ...
Laura Caleca (381198), Claudia Foglia (381199), Liliana Varesco (381200), Bernard Peissel (181321), Filomena Ficarazzi (181295), Giovanna De Vecchi (381197), Monica Barile (146605), Siranoush Manoukian (146603), Paolo Radice (146601), Mara Colombo (181275), Carla B. Ripamonti (196556)   +10 more
core   +1 more source

Identification and Computational Analysis of BRCA2 Variants in Mexican Women from Jalisco, Mexico, with Breast and Ovarian Cancer

Medical Sciences
Background: Breast and ovarian cancers (BC and OC) are prevalent malignancies in women globally, with germline variants in the BRCA2 gene significantly increasing the risk of developing these cancers.
Patricia Montserrat García-Verdín, José Elías García-Ortiz, Asbiel Felipe Garibaldi-Ríos, Ingrid Patricia Dávalos-Rodríguez, Sandra del Carmen Mendoza-Ruvalcaba, María Teresa Magaña-Torres, Luis E. Figuera, Mónica Alejandra Rosales-Reynoso, Cesar de Jesús Tovar-Jácome, Guillermo Moisés Zúñiga-González, Belinda Claudia Gómez-Meda, Blanca Miriam Torres-Mendoza, Raquel Villegas-Pacheco, René Gómez-Cerda, Julio César Cárdenas Valdez, Sergio Osvaldo Meza-Chavolla, Martha Patricia Gallegos-Arreola   +16 more
doaj   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells

, 2015
Silencing of the tumor suppressor protein BRCA2 and its detection by conventional biochemical analyses represent a great technical challenge owing to the large size of the human BRCA2 protein (approximately 390 kDa).
Giannattasio S., Guaragnella N, Moro L
core  

DNA Binding in High Salt: Analysing the Salt Dependence of Replication Protein A3 from the Halophile Haloferax volcanii [PDF]

Halophilic archaea maintain intracellular salt concentrations close to saturation to survive in high-salt environments and their cellular processes have adapted to function under these conditions.
Patoli, B, Bunting, KA, Winter, JA
core   +1 more source

Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu, Kaifeng Niu, Qingran Kong, Shaorong Gao   +3 more
wiley   +1 more source

Clinical significance of BRCA1 and BRCA2 mRNA and protein expression in patients with sporadic gastric cancer

, 2019
The purpose of the present study was to investigate the clinical significance of BRCA1/BRCA2 DNA repair associated (BRCA1/BRCA2) gene expression in patients with sporadic gastric cancer (GC) who had received postoperative adjuvant chemotherapy.
Hwang, In Gyu, Kim, Woo Ho, Min, Hye Young, Kim, Hee Sung, Bang, Yung-Jue   +4 more
core   +1 more source