Results 151 to 160 of about 67,862 (241)

Mapping genetic interactions in cancer: a road to rational combination therapies. [PDF]

, 2019
The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2 ...
Krogan, Nevan J, Tutuncuoglu, Beril
core  

Immunohistochemical expression of BRCA2 protein and allelic loss at the BRCA2 locus in prostate cancer [PDF]

International Journal of Cancer, 1998
Stephen M. Edwards, William D. Dunsmuir, Cheryl E. Gillett, Sunil R. Lakhani, Catherine Corbishley, Martin Young, Roger S. Kirby, David P. Dearnaley, Anna Dowe, Audrey Ardern‐Jones, Jo Kelly, Nigel Spurr, Diana M. Barnes, Rosalind A. Eeles   +13 more
openaire   +1 more source

BRCA2 and CDKN1A-Interacting Protein [PDF]

, 2020
openaire   +1 more source

Mismatch repair protein MLH1 suppresses replicative stress in BRCA2-deficient breast tumors

Journal of Clinical Investigation
Loss of BRCA2 (breast cancer 2) is lethal for normal cells. Yet it remains poorly understood how, in BRCA2 mutation carriers, cells undergoing loss of heterozygosity overcome the lethality and undergo tissue-specific neoplastic transformation. Here, we identified mismatch repair gene mutL homolog 1 (MLH1) as a genetic interactor of BRCA2 whose ...
Satheesh K. Sengodan, Xiaoju Hu, Vaishnavi Peddibhotla, Kuppusamy Balamurugan, Alexander Y. Mitrophanov, Lois McKennett, Suhas S. Kharat, Rahul Sanawar, Vinod Kumar Singh, Mary E. Albaugh, Sandra S. Burkett, Yongmei Zhao, Bao Tran, Tyler Malys, Esta Sterneck, Subhajyoti De, Shyam K. Sharan   +16 more
openaire   +2 more sources

Population testing for cancer predisposing BRCA1/BRCA2 mutations [PDF]

, 2014
Background: Technological advances raise the possibility of systematic population-based genetic testing for cancer-predisposing mutations, but it is uncertain whether benefits outweigh disadvantages.
Wardle, J
core  

BRCA1 and BRCA2 proteins are expressed in milk fat globules [PDF]

International Journal of Cancer, 1999
D J, Bernard-Gallon, P, Dechelotte, P G, Rio, Y J, Bignon   +3 more
openaire   +2 more sources

Adaptive Fuzzy C-Means with logit boost distributed clustering for cancer detection with protein sequences

Discover Applied Sciences
The Adaptive Fuzzy C-Means with Logit Boost Distributed Clustering (AFC-LBDC) technique is introduced to enhance cancer detection promptly. The various conventional techniques often struggle to improve cancer detection due to their high complexity ...
K. Thenmozhi, M. Pyingkodi, V. S. Prakash, Kripa Josten, S. Manju Priya, J. Vennila   +5 more
doaj   +1 more source

Protein–protein interactions of Fanconi anemia proteins FANCI, FANCD2 and BRCA2 [PDF]

Acta Crystallographica Section A Foundations and Advances, 2017
Mohd Quadir Siddiqui, Yogendra S. Rajpurohit, Hari S. Misra, Ashok K. Varma   +3 more
openaire   +1 more source

Rapid and sensitive detection of BRCA1/2 mutations in a diagnostic setting: Comparison of two high-resolution melting platforms [PDF]

, 2008
Claes, Kathleen, Coene, Ilse, De Leeneer, Kim, De Paepe, Anne, Poppe, Bruce   +4 more
core   +1 more source

Repression of EGFR by new biguanide 4C potentiated ovarian cancer to PARP inhibitors through down-regulation of BRCA2 and Rad51. [PDF]

Cell Death Dis
Xiao D, Yao J, Yang X, Xie Y, Zhou X, Li D, Peng M, Wang W, Zou H, Yang X.   +9 more
europepmc   +1 more source