Results 161 to 170 of about 67,862 (241)

From mutation to treatment: The dual role of BRCA1 and BRCA2 in gynecological malignancy development and management a systematic review. [PDF]

Biochem Biophys Rep
Georgy DM, Sedeek HN, Abaza NE, Eldeeb SEK, Khamis SM, Elgamil MR, Magar RW.   +6 more
europepmc   +1 more source

A Phase II Trial of Niraparib in Patients with Advanced Pancreatic Cancer Harboring Pathogenic Variants in ATM, BRCA1, BRCA2, PALB2, and CHEK2. [PDF]

Clin Cancer Res
Huffman BM, Diossy M, Yurgelun MB, Horick N, Li YY, Crowdis J, Nguyen H, Parmar K, Kochupurakkal BS, Vonk L, Lam H, Ramsey K, Andrews E, Loeb SC, Culnane L, Biller LH, Bullock AJ, Enzinger A, Giannakis M, Jackson NA, Ng K, Nowak JA, Patel AK, Perez KJ, Rattani A, Rubinson DA, Schlechter BL, Singh H, Cai M, Raghavan S, Clark JW, Peters ML, Weipert CM, Wolpin BM, D'Andrea AD, Shapiro GI, Aguirre AJ, Szallasi Z, Cleary JM.   +38 more
europepmc   +1 more source

BRCA1 and BRCA2 pathogenic variants increase the risk of four less common cancer types. [PDF]

ESMO Open
Sasagawa H, Endo M, Iwasaki Y, Usui Y, Koyanagi YN, Innella G, Hadler J, Parsons MT, Numakura K, Kamatani Y, Murakami Y, Matsuo K, Matsuda K, Spurdle AB, Habuchi T, Momozawa Y.   +15 more
europepmc   +1 more source

Production of recombinant human BRCA2 encoded proteins in Ecoli

, 1997
Ankara : The Department of Molecular Biology and Genetics and Institute of Engineering and Science, Bilkent Univ., 1997. Thesis (Master's) -- Bilkent University, 1997. Includes bibliographical references leaves 98-109. Breast cancer is known to be the most common cancer among women in the world.
openaire   +1 more source

Causative Role for a BRCA2 Germline Pathogenic Variant in External Auditory Canal Squamous Cell Carcinoma. [PDF]

Genes Chromosomes Cancer
Camacho-Valenzuela J, Pelletier D, Polak P, Fu L, Hamel N, Robles-Espinoza CD, Foulkes WD.   +6 more
europepmc   +1 more source

Comprehensive Investigation of a Novel Schiff Base: Synthesis, Anticancer Efficacy, Gene Expression Profiling, and Computational Analyses. [PDF]

Pharmaceuticals (Basel)
Agbektas T, Pazarcı Ö, Tas A, Huseynzada A, Guliyev R, Hasanova U, Buluz EC, Kaya S, Morales-Bayuelo A, Silig Y.   +9 more
europepmc   +1 more source

<i>BRCA2</i> Reversion Mutation after Neoadjuvant Dose-Dense EC and Dose-Dense Paclitaxel in Triple-Negative Breast Cancer: A Case Report and Literature Review. [PDF]

Surg Case Rep
Hikino H, Otani A, Makino Y.
europepmc   +1 more source

Integrating breast tumour homologous recombination deficiency status to aid germline BRCA1 and BRCA2 variant classification. [PDF]

EBioMedicine
Fortuno C, Zhang J, Koufariotis LT, Hollway G, Wood S, Pearson JV, Simpson PT, Lakhani SR, McCart Reed AE, Thorne H, Mann GB, Skandarajah AR, Devereux L, Zhao Q, De Silva DL, Lindeman GJ, Waring P, James PA, Campbell I, Spurdle AB, Waddell N.   +20 more
europepmc   +1 more source

Presence and prevalence of single nucleotide sequence polymorphisms in <i>TP53</i> and <i>BRCA2</i> genes as of cervical and ovarian cancers in women using hormonal contraceptives in Abuja, Nigeria. [PDF]

J Public Health Afr
Odebiyi OF, Kehinde A, Abdulsalami MS, Dibal DM.   +3 more
europepmc   +1 more source

Correction: Cosegregation analysis following an excellent response to olaparib in a pancreatic cancer patient carrier of BRCA2:c.7892 T > C variant enables its reclassification from VUS to pathogenic. [PDF]

BJC Rep
Strojnik K, Blatnik A, Krajc M, Novaković A, Ignjatović M, Ocvirk J, Stegel V, Škerl P, Klančar G, Novaković S, Šetrajčič Dragoš V.   +10 more
europepmc   +1 more source